Mass spectrometry combination with

Inoue Y, Kawabata K (1993) Speciation of organotin compounds by inductively coupled plasma mass spectrometry combined with liquid chromatography. Journal of the Mass Spectrometry Society of Japan, 41 (4) 245-251. 

Dworzanski, J. R Snyder, A. P. Chen, R. Zhang, H. Wishart, D. Li, L. Identification of bacteria using tandem mass spectrometry combined with a proteome database and statistical scoring. Anal. Chem. 2004,76,2355-2366. 

M.J. Casas Catalan and M.T. Domenech Carbo, Identification of natural dyes used in works of art by pyrolysis gas chromatography/mass spectrometry combined with in situ trimethylsilyla tion, Anal. Bioanal. Chem., 382, 259 268 (2005). 

Mass Spectrometry Combined with Inductively Coupled Plasma... 

Mass Spectrometry Combined with Instrumental Chromatography... 

A., and Roepstorff P. (2001), Characterization of a recombinant monoclonal antibody by mass spectrometry combined with bquid chromatography. J. Chromatogr. 

The quasi-simultaneous separation and determination of lanthanides and actinides by ion chromatography inductively coupled plasma mass spectrometry combined with the isotope dilution technique and the further use of ion chromatography for the determination of fission products and actinides in nuclear applications are described by Betti et ul.10 48 68... 

The nitrogen compounds in the heavy oil were shown to be 40% weak base, 14% very weak base, and 46% neutral compounds. Mass spectrometry was used to classify the weak bases as 72% pyridines (one aromatic ring), 24% quinolines (two aromatic rings), and 4% acridines (three aromatic rings). Mass spectrometry combined with infrared analysis and pyrrolic-nitrogen determination were used to classify the very weak base and neutral nitrogen compounds as 7% pyrroles or indoles with either or both of the a and ft positions open and not N-substituted, 22% pyrroles or indoles with substitution on both a and p positions but no N-substitutions, 34% carbazoles with no N-substitutions, and 37% N-substituted carbazoles. 

Perestrelo, R., Barros, A. S., Camara, J. S., and Rocha, S. M. (2011). In-depth search focused on furans, lactones, volatile phenols, and acetals as potential age markers of Madeira wines by comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry combined with solid phase microextraction. ]. Agric. Food Chem. 59, 3186-3204. 

Wang F, Weidt S, Xu J, Mackay CL, Langridge-Smith PRR, Sadler PJ (2008) Identification of clusters from reactions of ruthenium arene anticancer complex with glutathione using nanoscale liquid chromatography fourier transform ion cyclotron mass spectrometry combined with 180-labeling. J Am Soc Mass Spectrom 19 544-549... 

S. Yali, G. Xiyun, D. Andao, Determination of platinum group elements by inductively coupled plasma-mass spectrometry combined with nickel sulphide E>re assay and tellurium coprecipitation, Spectrochim. Acta, 53B (1998), 1463D1467. 

The use of mass spectrometry combined with GC does not necessitate derivatives other than those used in GC itself. In spite of this, particularly recently, special derivatives for GC-MS have been developed, some of which are mentioned in this book. Derivatives are considered that provide characteristic mass spectra and facilitate identification and quantitative evaluation. Various trialkylsilyl derivatives [7] are an example. They do not offer any particular improvement over conventional TMS derivatives from the viewpoint of the chromatographic analysis, but their highly characteristic fragments permit the sample compounds under analysis to be identified unambiguously in GC—MS. 

Oehme M, Kirschmer P (1984), Anal. Chem. 56 2754-2759. Isomer-selective determination of tetrachlorinated dibenzo-p-dioxins using hydroxyl negative ion chemical ionization mass spectrometry combined with high resolution gas chromatography"... 

Several endeavors are being directed towards identifying biomarkers that can serve as a surrogate indicator of disease severity, in terms of either overall disease burden or involvement of a particular organ/system in patients with an LSD. In mucopolysaccharidosis type I, the analysis of the levels of oligosaccharides derived from GAGs in cultured fibroblasts (as measured by electrospray ionization tandem mass spectrometry) combined with the residual a-L-iduronidase activity have been shown to distinguish patients with and without CNS involvement (Fuller et al.,... 

Porphyrin (see Porphyrin) molecules containing peripheral pyridine groups act as comers or 180° linkers depending on the positions of the pyridyl donor atoms. Reaction of (dppp)Pd(OTf)2 with (47) yields the molecular square (14) while a larger square (49) was obtained by employing a modified porphyrin (48) in which the two pyridine units are trans to each other (Scheme 15). The results of these reactions demonstrate that the ability of the molecular components to act as comers or linkers depends on their topologies. Bis-pyridyl-porphyrin (47) reacts with cis- and trani -(PhCN)2PdCl2 to yield the molecular squares (50) and (51), respectively, with varied dimensions. These squares have been characterized by NMR spectroscopy and mass spectrometry combined with UV-visible spectroscopy (see UV- Visible Spectroscopy) and vapor-phase osmometry. 

Y Shinohara, K Nagao, N Akutsu, S Baba. Assessment of the metabolic chiral inversion of suprofen in rat by gas chromatography-mass spectrometry combined with a stable isotope technique. J Pharm Sci 83 1521—1523, 1994. 

Screening of estuarine and marine sediment samples by automated pyrolysis mass spectrometry combined with factor-discriminant analysis leads to a useful classification related to the geographical position and the sources of the organic matter. The mass spectral data give preliminary information about the organic matter composition. Analysis of the characteristic mass peaks m/z=86 and 100 by PMSMS and PGCMS points to bacterial poly-alkanoates in the mud fraction of the river sediments. 

The pyrolysis methods applied in this study are used as a tool for a general characterization of the organic matter from the sediments. We describe here the results from screening of estuarine and open sea sediment samples by automated pyrolysis low voltage mass spectrometry combined with factor-discriminant analysis. Characteristic mass peaks resulting from this procedure were investigated in more detail by pyrolysis-tandem mass spectrometry and pyrolysis-photoionization GCMS. 

N.C. Yang, K.L. Hwang, C.H. Shen, H.F. Wang, W.M. Ho, Simultaneous determination of fluorinated inhalation anesthetics in blood by gas chromatography-mass spectrometry combined with a headspace autosampler, J. Chromatogr. B, 159, 307-318 (2001). 

Fang SP, Hao CY, Sun WX, Liu ZQ, Liu SY (1998) Rapid Analysis of Steroidal Saponin Mixture Using Electrospray Ionization Mass Spectrometry Combined with Sequential Tandem Mass Spectrometry. Rapid Commun Mass Spectrom 12 589... 

Jeannot, R., Sabik, H., Sauvard, E., and Genin, E., Application of liquid chromatography with mass spectrometry combined with photodiode array detection and tandem mass spectrometry for monitoring pesticides in surface water, J. Chromatogr. A, 818, 51-71, 2000. 

TLC can provide other information critical in compound identification. Colors from selective chemical detection reactions, behavior in ultraviolet light, absorbance and/or fluorescence spectra obtained directly on the chromatogram by use of a spectrodensitometer or in solution after elution and Rp values of derivatives prepared by reaction before, during, or after development can be combined with the R p values of the sample to increase the degree of probability of correct identification [67,68]. Infrared (IR) and mass spectrometry combined with chromatography can provide unequivocal identification if sufficient sample is available. This is often not the case in trace analysis where nanogram amounts of material may be separated and detected by TLC, whereas microgram quantities are needed for conventional IR spectrometric confirmation of the trace substances. 

Shazali 1, Van t Dack L, Gijbels R (1987) Determination of precious metals in ores and rocks by thermal neutron activation/y-spectrometry after preconcentration by nickel sulfide fire assay and coprecipitation with tellurium. Anal Chim Acta 196 49-58 Stembeck J, Sjodin A, Andreasson K (2002) Metal emissions from road traffic and the influence of resuspension—results from two tunnel studies. Atmos Env 36 4735-4744 Sun Y, Guan X, Du A (1998) Determination of platinum group elements by inductively coupled plasma-mass spectrometry combined with nickel sulfide fire assay and tellurium coprecipitation. Spectrochim Acta B 53 1463-1467... 

FIGURE 3.15 Schematic of a typical DESI experiment. (From Weston et al. Direct analysis of pharmaceutical drug formulations using ion mobility spectrometry/quadrupole-time-of-flight mass spectrometry combined with desorption electrospray ionization Anal. Chem. 2005, 77(23), 7572-7580. 

Li HJ, Jiang Y, Li P. Characterizing distribution of steroidal alkaloids in Fritillaria spp. and related compound formulas by liquid chromatography-mass spectrometry combined with hierarchial cluster analysis. J Chrom 2009 1216(ll) 2142-9. 

Selected Publications on the Characterization of Oligomeric/ Polymeric Samples by ESI or APCl Mass Spectrometry Combined with On-Line Separation... 

Dai DM, He JM, Sun RX, Zhang RP, Haji AA, Abliz Z. Nuclear magnetic resonance and liquid chromatography—mass spectrometry combined with an incompleted separation strategy for identif5nng the natural products in crude extract. Anal Chim Acta 2009 632 221-228. 

Urlaub, H., Thiede, B., Muller, E.C., Brimacombe, R., and Wittmann-Liebold, B. (1997) Identification and sequence analysis of contact sites between ribosomal proteins and rRNA in Escherichia coli 30 S subunits by a new approach using matrix-assisted laser desorption/ionization-mass spectrometry combined with N-terminal... 

Przybilla, L., Francke, V., Raeder, H.)., and Muellen, K. (2001) Block length determination of a poly(ethylene oxide)-b-poly(p-phenylene ethynylene) diblock copolymer by means of MALDI-TOF mass spectrometry combined with fragment-ion analysis. Macromolecuks, 34, 4401-4405. 

Niwa, M. Watanabe, N. Ochiai, H. Yamashita, K. Determination of testosterone concentrations in rat plasma using liquid chromatography-atmospheric pressure chemical ionization mass spectrometry combined with ethyl oxime and acetyl ester derivahzation. J. Chromatogr. B, 2005, 824 (1-2), 258-266. 

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