Mass spectrometry combined with liquid

Inoue Y, Kawabata K (1993) Speciation of organotin compounds by inductively coupled plasma mass spectrometry combined with liquid chromatography. Journal of the Mass Spectrometry Society of Japan, 41 (4) 245-251. 

Queiroz, E.F. et al., On-line identification of the antifungal constituents of Erythrina vogelii by liquid chromatography with tandem mass spectrometry, ultraviolet absorbance detection and nuclear magnetic resonance spectrometry combined with liquid chromatographic micro-fractionation, J. Chromatogr. A, 972, 123, 2002. 

Wang F, Weidt S, Xu J, Mackay CL, Langridge-Smith PRR, Sadler PJ (2008) Identification of clusters from reactions of ruthenium arene anticancer complex with glutathione using nanoscale liquid chromatography fourier transform ion cyclotron mass spectrometry combined with 180-labeling. J Am Soc Mass Spectrom 19 544-549... 

Jeannot, R., Sabik, H., Sauvard, E., and Genin, E., Application of liquid chromatography with mass spectrometry combined with photodiode array detection and tandem mass spectrometry for monitoring pesticides in surface water, J. Chromatogr. A, 818, 51-71, 2000. 

Li HJ, Jiang Y, Li P. Characterizing distribution of steroidal alkaloids in Fritillaria spp. and related compound formulas by liquid chromatography-mass spectrometry combined with hierarchial cluster analysis. J Chrom 2009 1216(ll) 2142-9. 

Dai DM, He JM, Sun RX, Zhang RP, Haji AA, Abliz Z. Nuclear magnetic resonance and liquid chromatography—mass spectrometry combined with an incompleted separation strategy for identif5nng the natural products in crude extract. Anal Chim Acta 2009 632 221-228. 

Niwa, M. Watanabe, N. Ochiai, H. Yamashita, K. Determination of testosterone concentrations in rat plasma using liquid chromatography-atmospheric pressure chemical ionization mass spectrometry combined with ethyl oxime and acetyl ester derivahzation. J. Chromatogr. B, 2005, 824 (1-2), 258-266. 

Chen, G., Cao, R, and Liu, R. 2011. A multi-residue method for fast determination of pesticides in tea by ultra performance liquid chromatography-electrospray tandem mass spectrometry combined with modified QuEChERS sample preparation procedure. Food Chem. 125 1406-1411. 

Bai Y, Zhang J, Hiu H. Direct analysis in real time mass spectrometry combined with single-drop liquid-liquid-microextraction for rapid analysis of multiple phytohormones in fruit juice. Anal Bioanal Chem. 2012 403 2307-14. 

Nagy, K., Jakab, A., Pollreisz, R, Bongiomo, D., Ceraulo, L., Averna, R.M., Noto, D. and Vekey, K., Analysis of sterols by high-performance liquid chromatography/mass spectrometry combined with chemometrics. Rapid Commun. Mass Spectrom., 20, 2433-2440 (2006). 

The results for bacterial whole-cell analysis described here establish the utility of MALDI-FTMS for mass spectral analysis of whole-cell bacteria and (potentially) more complex single-celled organisms. The use of MALDI-measured accurate mass values combined with mass defect plots is rapid, accurate, and simpler in sample preparation then conventional liquid chromatographic methods for bacterial lipid analysis. Intact cell MALDI-FTMS bacterial lipid characterization complements the use of proteomics profiling by mass spectrometry because it relies on accurate mass measurements of chemical species that are not subject to posttranslational modification or proteolytic degradation. 

Dai S. et al., 2005. Quantitation of sifuvirtide in monkey plasma by an online solid-phase extraction procedure combined with liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom 19 1273. 

Many separation and detection methods applied in combination with liquid chromatography (LC) that are described in the literature for the determination of surfactants are not specific to the detection of these compounds at trace levels. Even ultraviolet (UV) spectra obtained from diode array detectors often give only limited information. Furthermore, non-reproducible retention behaviour as well as coelution interference effects are frequently observed during the separation of surfactant-containing extracts. This is recognised, however, only in those cases where specific detection methods such as mass spectrometry (MS) are applied. 

This pharmaceutical revolution could not have been achieved without the under-girdment of advanced analytical instrumentation. Mass spectrometry (MS) combined with liquid chromatography (LC) has enabled the characterization of novel potential dmgs as well as quantitative measurement in an increasingly complex milieu at an incredibly rapid throughput rate. Quantitation of dmgs in biological media such as... 

Advanced analytical techniques, particularly mass spectrometry (MS), often combined with liquid chromatography (LC) or gas chromatography (GC), are requisite for lipid analysis and they have played the crucial role in the emergence as well as the progresses of lipidomics. MS is the principal choice for the lipid analysis, particularly using electrospray ionization (ESI) and sometimes also atmospheric pressure chemical ionization or laser-based MS methods for surface analysis. The MS-based techniques are the best choice for lipidomics due to their superior sensitivity and molecular specificity, and because they provide the ability to resolve the extensive compositional and structural diversity of lipids in biological systems. 

Halvorsen TG, Pedersen-Bjergaard S, Reubsaet JLE et al (2003) Liquid-phase microextraction combined with liquid chromatography-mass spectrometry. Extraction from small volumes of biological samples. J Sep Sci 26 1520-1526... 

Fernandez MDR, Wille SMR, Samyn N, Wood M, Lopez-Rivadulla M, De Boeck G (2009) On-line solid-phase extraction combined with liquid chromatography-tandem mass spectrometry for high throughput analysis of 1 l-nor-Delta(9)-tetrahydrocannabinol-9-carboxylic acid in urine. J Chromatogr B 877(22) 2153—2157. doi 10.1016/j.jchromb.2009.04.047... 

Since 2000, a myriad of LC-MS techniques have been reported to detect an array of NMBAs. These methods are valuable because they are generally more sensitive and more practical because they can measure a number of NMBAs simultaneously. Likewise, pharmacokinetic studies of neuromuscular blockers require low detection limits (sensitive chromatographic techniques such as tandem mass spectrometry with electrospray ionization combined with liquid chromatographic separation (LC-ESI-MS-MS) are better suited for these types of clinical applications.Brief descriptions of representative LC-MS methods follow. 

METHOD FOR THE DETERMINATION OF SOME SELECTED STEROID HORMONES AND BISPHENOL A IN WATER AT LOW NG/L LEVEL BY ON-LINE SOLID-PHASE EXTRACTION COMBINED WITH LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY... 

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