Insulin glucose

Spellacy, W.N. Buhl, W.C. Spellacy, C.E. Moses, L.E. and Golzleher, J.W. "Glucose, Insulin and Growth Hormone Studies In Long Term Uses of Oral Contraceptives". Amer. J. Obstet. Gynecol. (1970), li, 173-176. 

Scott JF, Robinson GM, French JM, O Connell JE, Alberti KG, Gray CS. Glucose potassium insulin infusions in the treatment of acute stroke patients with mild to moderate hyperglycemia the glucose insulin in stroke trial (GIST). Stroke 1999 30 793-799. 

Hypoglycaemia remains the most frequent complication of insulin administration to diabetics. It usually occurs due to (a) administration of an excessive amount of insulin (b) administration of insulin prior to a mealtime, but with subsequent omission of the meal or (c) due to increased physical activity. In severe cases this can lead to loss of consciousness, and even death. Although it may be treated by oral or i.v. administration of glucose, insulin-induced hypoglycaemia is sometimes treated by administration of glucagon. 

Anderson, J. W., O Neal, D. S., Riddell-Mason, S., Floore, T. L., Dillon, D. W., and Oeltgen, P. R. (1995). Postprandial serum glucose, insulin, and lipoprotein responses to high- and low-fiber diets. Metabolism 44, 848-854. 

HV185 Bourdon I., W. Yokoyama, P. Davis, et al. Postprandial lipid, glucose, insulin, and cholecystokinin responses in men fed barley pasta enriched with beta-glucan. Am J Clin Nutr 1999 69(1) 55-63. 

The 3,4-dihydro-22/-l,3-benzoxazin-4-one derivative DRF-2519 587, bearing a 2,4-thiazolidinedione moiety in the side chain attached to the nitrogen atom, proved to be an activator of the a- and y-types of the peroxisome proliferator-activated receptors (PPAR-a and -7), which endowed it with antidiabetic and hypolipidemic potential. Compound 587 demonstrated significant plasma glucose-, insulin-, and lipid-lowering activity in mice and improvement in lipid parameters in fat-fed rats <2006BMC584>. 

This phosphatase converts phosphorylase a to phosphorylase b, sharply reducing the activity of phosphorylase and slowing glycogen breakdown in response to high blood glucose. Insulin also acts indirectly to stimulate PP1 and slow glycogen breakdown. 

Changes in blood levels of glucose, insulin, and glucagon after ingestion of a carbohydrate-rich meal. 

Kemp BK, Cocks TM (1999) Adenosine mediates relaxation of human small resistance-like coronary arteries via A2B receptors. Br J Pharmacol 126(8) 1796-1800 Kersten JR, Toller WG, Gross ER, Pagel PS, Warltier DC (2000) Diabetes abolishes ischemic preconditioning role of glucose, insulin, and osmolality. Am J Physiol Heart Circ Physiol 278(4) H1218-H1224... 

There were no differences in episodes of hypoglycemia, concentrations of glucose, insulin, HbAlc, or lipids, or body weight when glibenclamide was given in one daily dose instead of divided doses (159). 

Diabetes was also more common in 63 patients taking clozapine than in 67 receiving typical depot neuroleptic drugs (299). The percentages of type 2 diabetes mellitus were 12% and 6% respectively. Nevertheless, the mechanism is not known. In six patients with schizophrenia, clozapine increased mean concentrations of blood glucose, insulin, and C peptide (300). The authors concluded that the glucose intolerance was due to increased insulin resistance. 

Choose method and schedule for blood collection. Common survival blood collection methods for metabolic profiling are tail-nick, tail snip, saphenous vein, submandibular (cheek), and retroorbital bleeding. With the tail nick or tail snip blood collection methods, 75 pi samples of blood can be collected up to four times in a 1-day experiment, not exceeding a total of 250 pi, and are used as default blood collection procedures. This usually provides up to 30 pi serum samples and is sufficient to measure glucose, insulin, and other metabolic markers. In some cases, larger... 

Tail Snip Blood Collection for Multiple Measurements Baseline Glucose, Insulin, and UEFA... 

Glucose insulin potassium (GIK) infusion has been suggested by some to offer additional myocardial salvage in the setting of an acute Ml. Theoretically, GIK infusion provides glycolytic fuel to both the starving ischemic myocardium before intervention and the reperfused myocardium after PCI. It is also thought to decrease free fatty acid (FFA) levels and toxic FFA uptake by the ischemic myocardium. 

Fath-Ordoubadi p Beatt KJ. Glucose-insulin-potassium therapy for treatment of acute myocardial infarction an overview of randomized placebo-controlled trials. Circulation 1997 96 1 152-1 156. 

Ceremuzynski L, Budaj A, Czepiel A, et al. Low-dose glucose-insulin-potassium is ineffective in acute myocardial infarction results of a randomized multicenter Pol-GIK trial. Cardiovasc Drugs Ther 1999 13 191-200. 

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