Insulin receptor signal transduction glucose transporter

S. J. Hunter and T. Garvey Insulin action and insulin resistance Diseases involving defects in insulin receptors, signal transduction, glucose transport effector system. American Journal of Medicine 105, 331 (1998). 

Because the primary eveuts between insulin binding to its receptor and glucose transport are signal transduction events, a role for chromodulin in these events has been probed. Chromoduhn activates the tyrosine kinase activity of insulin-activated insulin receptor and activates a membrane phosphotyrosine phosphatase in adipocyte membranes. The addition of bovine liver chromodulin to rat adipocytic membranes in the presence of insuhn results in a concentration-dependent eightfold stimulation of insulin-dependent protein tyrosine kinase activity (while no activation... 

RD Hoffman, MD Lane. lodophenylarsine oxide and arsenical affinity chromatography New probes for dithiol proteins. Application to tubulins and to components of the insulin receptor-glucose transporter signal transduction pathway. 1 Biol Chem 267 14005-14011, 1992. 

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