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Glucose responsive insulin delivery

The ultimate goal of insulin replacement therapy is a closed-loop controlled system or device in which the insulin release rates are adjusted by the system in response to glucose levels in the blood. Several different approaches for glucose-responsive insulin delivery have been investigated. [Pg.366]

Two approaches are discussed for the preparation of enzymatically controlled drug delivery systems a calcium-responsive biodegradable drug delivery system based on a mixture of starch with HPMC (hydroxypropyl methyl cellulose ether) (biodegradable) and the starch hydrolytic enzyme, alpha-amylase, in its non-active form and a glucose responsive insulin delivery system based on the hydrogel poly(2-hydroxyethyl methacrylate-co-N,N-dimethylaminoethyl methacrylate), with entrapped glucose oxidase, catalase and insulin. In both systems, the sensitivity... [Pg.64]

Zahn JD, Hsieh YC, Yang M (2005) Components of an integrated microfluidic device for continuous glucose monitoring with responsive insulin delivery. Diabetes Technol Ther 7(3) 536-545... [Pg.1417]

Fig. 27 Cross-sectional view of a bioresponsive insulin delivery system, a feedback-regulated drug delivery system, showing the glucose oxidase-entrapped hydrogel membrane constructed from amine-containing hydrophilic pol5mier. The mechanism of insulin release, in response to the influx of glucose, is also illustrated. (From Ref. l)... Fig. 27 Cross-sectional view of a bioresponsive insulin delivery system, a feedback-regulated drug delivery system, showing the glucose oxidase-entrapped hydrogel membrane constructed from amine-containing hydrophilic pol5mier. The mechanism of insulin release, in response to the influx of glucose, is also illustrated. (From Ref. l)...
Dose reproducibility Several human studies comparing aerosol insulin administration to subcutaneously administered insulin showed that the variability in glucose response from a liquid nebulizer that utilized the standing cloud concept was equivalent or better than that seen with insulin injection. Inhale Therapeutics Systems, Inc. has adopted this standing cloud concept for its dry powder inhaler to achieve reproducibility of delivery of macromolecules to the systemic circulation that is equivalent to subcutaneous injections. [Pg.1285]

Gu, Z., Dang, T.T., Ma, M., Tang, B.C., Cheng, H., Jiang, S., 2013. Glucose-responsive microgels integrated with enzyme nanocapsules for closed-loop insulin delivery. ACS Nano 7, 6758—6766. [Pg.148]

Yin, R., Han, J., Zhang, J., Nie, J., 2010. Glucose-responsive composite microparticles based on chitosan, concanavaUn A and dextran for insulin delivery. Colloids and Surfaces B Biointerfaces 76, 483—488. [Pg.154]

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