Glucose and insulin

Spellacy, W.N. Buhl, W.C. Spellacy, C.E. Moses, L.E. and Golzleher, J.W. "Glucose, Insulin and Growth Hormone Studies In Long Term Uses of Oral Contraceptives". Amer. J. Obstet. Gynecol. (1970), li, 173-176. 

Anderson, J. W., O Neal, D. S., Riddell-Mason, S., Floore, T. L., Dillon, D. W., and Oeltgen, P. R. (1995). Postprandial serum glucose, insulin, and lipoprotein responses to high- and low-fiber diets. Metabolism 44, 848-854. 

HV185 Bourdon I., W. Yokoyama, P. Davis, et al. Postprandial lipid, glucose, insulin, and cholecystokinin responses in men fed barley pasta enriched with beta-glucan. Am J Clin Nutr 1999 69(1) 55-63. 

The 3,4-dihydro-22/-l,3-benzoxazin-4-one derivative DRF-2519 587, bearing a 2,4-thiazolidinedione moiety in the side chain attached to the nitrogen atom, proved to be an activator of the a- and y-types of the peroxisome proliferator-activated receptors (PPAR-a and -7), which endowed it with antidiabetic and hypolipidemic potential. Compound 587 demonstrated significant plasma glucose-, insulin-, and lipid-lowering activity in mice and improvement in lipid parameters in fat-fed rats <2006BMC584>. 

Changes in blood levels of glucose, insulin, and glucagon after ingestion of a carbohydrate-rich meal. 

Kemp BK, Cocks TM (1999) Adenosine mediates relaxation of human small resistance-like coronary arteries via A2B receptors. Br J Pharmacol 126(8) 1796-1800 Kersten JR, Toller WG, Gross ER, Pagel PS, Warltier DC (2000) Diabetes abolishes ischemic preconditioning role of glucose, insulin, and osmolality. Am J Physiol Heart Circ Physiol 278(4) H1218-H1224... 

Diabetes was also more common in 63 patients taking clozapine than in 67 receiving typical depot neuroleptic drugs (299). The percentages of type 2 diabetes mellitus were 12% and 6% respectively. Nevertheless, the mechanism is not known. In six patients with schizophrenia, clozapine increased mean concentrations of blood glucose, insulin, and C peptide (300). The authors concluded that the glucose intolerance was due to increased insulin resistance. 

Choose method and schedule for blood collection. Common survival blood collection methods for metabolic profiling are tail-nick, tail snip, saphenous vein, submandibular (cheek), and retroorbital bleeding. With the tail nick or tail snip blood collection methods, 75 pi samples of blood can be collected up to four times in a 1-day experiment, not exceeding a total of 250 pi, and are used as default blood collection procedures. This usually provides up to 30 pi serum samples and is sufficient to measure glucose, insulin, and other metabolic markers. In some cases, larger... 

Tail Snip Blood Collection for Multiple Measurements Baseline Glucose, Insulin, and UEFA... 

Kemnitz, M. W., Elson, D. F., Roecker, E. B., Baum, S. T., Bergman, R. N., and Meglasson, M. D. (1994). Pioglitazone Increases Insulin Sensitivity, Reduces Blood Glucose, Insulin, and Lipid Levels, and Lowers Blood Pressure in Obese, Insulin-Resistant Rhesus Monkeys. Diabetes AS, 204-211. 

C. Simon, G. Brandenberger, and M. Fol-lenius Ultradian oscillations of plasma glucose, insulin and C-peptide in man. J. Clin. Endocrinol. Metab. 1987, 64 669-675. 

Rumessen, J.J., Bode, S., Hamberg, O., and Gudmand-Hpyer, E., Fructans of Jerusalem artichokes intestinal transport, absorption, fermentation, and influence on blood glucose, insulin and C-peptide responses in healthy subjects, Am. J. Clin. Nutr., 52, 675-681, 1990. 

Figure 10-6. Plasma glucose, insulin, and glucagon concentrations in infants from diabetic mothers. IIV, umbilical vein. Reprinted with permission from Girard et al. (1992).

Figure 5-35. Changes in blood glucose, insulin, and glucagon levels in response to a glucose or a protein meal.

Physical and mental stress influence the concentrations of many plasma constituents. Anxiety stimulates increased secretion of aldosterone, angiotensin, catecholamines, cortisol, prolactin, renin, somatotropin, TSH, and vasopressin. Plasma concentrations of albumin, cholesterol, fibrinogen, glucose, insulin, and lactate also increase. 

Complications and Fasting blood glucose Insulin and oral... 

Steffens AB, Mogenson GJ, Stevenson JA. 1972. Blood glucose, insulin, and free fatty acids after stimulation and lesions of the hypothalamus. Am J Physiol 222 1446-1452. 

Blood samples for glucose, insulin and C-peptide were taken just before dosing, and during the next 4h (i.e., -30, 0, -tl5. 

Fig. 31.12. Blood glucose, insulin, and glucagon levels after a high-carbohydrate and a high-protein meal.

Fig. 31.13. Blood glucose, insulin, and glucagon levels over a 24-hour period in a normal person eating mixed meals. Reprinted with permission from Tasaka Y, Sekine M, Wakatsuki M, et al. Horm Metab Res 1975 7 206. Copyright Thieme Medical Publishers, Inc.

Hollenbeck CB, Johnston P, Varasteh, BB, et al. Effects of metformin on glucose insulin and lipid metabolism in patients with mUd hypeitryglyceridaemia and noninsulin dependent diabetes by glucose tolerance test criteria. Diabete Metab 1991 17 483 89. 

Reaven GM. Effect of metformin on various aspects of glucose, insulin and lipid metabolism in patients with non-insulin-dependent diabetes mellitus with varying degrees of hyperglycemia. Diab/Metab Rev 1995 11 S97-S108. 

Segrestaa JM, Caulin C, Dahan R, Houlbert D, Thiercelin JF, Herman P, Sauvanet JP, Laur-ribaud J. Effect of diltiazem on p sma glucose, insulin and glucagcs during an oral glucose tolerance test in healthy volunteers. EurJ Clin Pharmacol (1984) 26,481-3. 

Bruno A, Carucci P, Cassader M, Cavallo-Perin P, Gruden G, Olivetti C, Pagano G. Serum glucose, insulin and C-peptide response to oral glucose after intravenous adninistration of hydrocortisone and methylprednisolone in man. EurJ Clin Pharmacol ( 994) 46, 411-15. 

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