Muscle glucose uptake insulin deficiency

Type 2 DM accounts for as many as 90% of DM cases and is usually characterized by the presence of both insulin resistance and relative insulin deficiency. Insulin resistance is manifested by increased lipolysis and free fatty acid production, increased hepatic glucose production, and decreased skeletal muscle uptake of glucose. )3-Cell dysfunction is progressive and contributes to worsening blood glucose control over time. Type 2 DM occurs when a diabetogenic lifestyle (excessive calories, inadequate exercise, and obesity) is superimposed upon a susceptible genotype. 

Type 1 diabetes is a disease for which the use of prosthetic networks is also being considered. The deficiency in insulin decreases the insiiUn-dependent glucose transporter (GLUT-4) that mediates glucose uptake in fat and muscle. Therefore the body needs to find alternative energy sources. This leads to an excessive uncontrolled lipolysis in the adipose tissues resulting in excessive production of acidic ketone bodies in the liver, which accumulate in the bloodstream, overwhelm the acid-base... 

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