Glucose-induced insulin release

Lopez et al. reported the isolation of three quinolizidine alkaloids such as lupanine (30), 13-a-hydroxylupanine (31), and 17-oxo-lupanine (32) from Lupinus perennis Wild, (family Fabaceae) all these three isolates were found to have potent activity in enhancing glucose-induced insulin release from isolated rat islet cells in a glucose concentration-dependent manner. While the synthetic compound 2-thionosparteine... 

Buscema, M., Vinci, C., Gatta, C., Rabuazzo, M. A., Vignen, R., and Purrello, F. (1992). Nicotinamide partially reverses the interleukin lj3 inhibition of glucose-induced insulin release in pancreatic islets. Metabolism 41, 296-300. 

Bed-rest experiments have previously shown changes in homeostasis (for example, glucose-induced insulin release) but no change in plasma catecholamine concentrations. 

Feedback Inhibition of Insulin Secretion. Whether or not feedback inhibition of insulin secretion occurs is still under debate since the data from many studies are contradictory. In particular, in vivo administration of insulin has given controversial results. However, in vitro where exogenous insulin was added to pancreatic islets or to the perfused pancreas, it showed inhibition of glucose-induced insulin release (Ammon and Verspohl, 1976 ... 

Some imidazoline substances were shown to enhance the glucose induced insulin release from pancreatic p cells [35,58]. This effect was not mediated by a-adrenoceptors but appeared to involve some specific imidazoline sites [86]. Moreover, these cells expressed recognition sites specific for imidazolines but different from the II- or l2-receptors. In fact, imidazoline compounds such as efaroxan and antazoline were shown to potently stimvdate insulin secretion ( fig 2). The latter effect was also attributed to a specific action on pancreatic imidazohne receptors [59]. 

Salehi, A, Henningsson, R, Mosen, H, Ostenson, CG, Efendic, S, and Lundquist, I, Dysfunction of the islet lysosomal system conveys impairment of glucose-induced insulin release in the diabetic gk rat. Endocrinology, 1999. 140(7) 3045-3053. 

A protective role for OL extracted from olive leaves against diabetic disease was first postulated by Gonzalez et al. in the early 1990s [152]. In that study, the hypoglycemic effect of OL in animals with alloxan-induced diabetes was attributed to a potentiation of glucose-induced insulin release and parallel increased peripheral uptake of glucose [152]. Subsequent studies evidenced a stronger link of the antidiabetic action with the antioxidant effects of OL. The role played by OS for diabetes complications such as retinopathy, nephropathy, and coronary heart... 

In an effort to explain these observations, Malaisse et al. (1975) suggested a sequence of events in the endocrine cells. During the early phase of glucose-induced insulin release, secretory vesicles already near the cellular web and plasma membrane are discharged. This secretion phase is independent of microtubule function and hence is affected... 

Malaisse, W. J., Sener, A., Koser, M., and Herchuelz, A., 1976, Stimulus-secretion coupling of glucose-induced insulin release, /. Biol. Chem. 251 5936. 

---