Glucose insulin self-regulated delivery

G Albin, TA Horbett, BD Ratner. Glucose-sensitive membranes for controlled release of insulin. In J Kost, ed. Pulsed and Self-Regulated Drug Delivery. Boca Raton, FL CRC Press, 1990, pp 159-185. 

Further development of the self-regulating insulin delivery system has utilized the complex of glycosylated insulin-concanavalin A, which is encapsulated inside a polymer membrane. As glucose penetrates into the system, it activates the release of glycosylated insulin from the complex for a controlled release from the system (Fig. 28). The amount of insulin released is thus self-regulated by the concentration of glucose that has penetrated into the insulin delivery system. 

Fig. 28 Various components of a self-regulating insulin delivery system, a feedback-regulated drug delivery system, and its control of blood glucose level in the pancreatectomized dogs. (From Ref. l)...

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