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Expression profiles

Landgrebe J, Welzl G, Metz T et al (2002) Molecular characterisation of antidepressant effects in the mouse brain using gene expression profiling. J Psychiatr Res 36 119-129... [Pg.116]

Refers to the physical substrate to which biological samples are attached to create features (spots). In gene expression profiling arrays are hybridized with labeled sample and then scanned and analyzed to generate data. [Pg.222]

Gene Expression Analysis. Figure 2 Contribution of gene expression profiling to the drug discovery process. [Pg.529]

The most common application of microarray technology is in monitoring gene expression (gene expression profiling). [Pg.765]

Toxicology Many companies are known to use gene expression profiling to assess the potential toxicity of lead compounds. This approach may require a database of reference compounds with known pharmacological and toxicological properties. Lead compounds can be compared to the database to predict compound-related or mechanism-related toxicity [5]. [Pg.769]

Filby, A.L., Thorpe, K.L., Maack, G. et al. (2007b). Gene expression profiles revealing the mechanisms of anti-androgen and estrogen-induced feminization in fish. Aquatic... [Pg.347]

Hughes TR, Marton MJ, Jones AR, Roberts CJ, Stoughton R, Armour CD, et al. Eunctional discovery via a compendium of expression profiles. Cell 2000 102 109-26. [Pg.160]

Li Y, Hong X, Hussain M, Sarkar SH, Li R, Sarkar FH. Gene expression profiling revealed novel molecular targets of docetaxel and estramustine combination treatment in prostate cancer cells. Mol Cancer Ther 2005 4 389-98. [Pg.164]

Luo W, Fan W, Xie H, ling L, Ricicki E, Vouros P, et al. Phenotypic anchoring of global gene expression profiles induced by A -hydroxy-4-acetylaminobiphenyl and benzo[a]pyrene diol epoxide reveals correlations between expression profiles and mechanism of toxicity. Chem Res Toxicol 2005 18 619-29. [Pg.165]

Ise R, Han D, Takahashi Y, Terasaka S, Inoue A, Tanji M, et al. Expression profiling of the estrogen responsive genes in response to phytoestrogens using a customized DNA microarray. FEBS Lett 2005 579 1732-40. [Pg.165]

Sorensen TL, Sellebjerg F (2001) Distinct chemokine receptor and cytokine expression profile in secondary progressive MS. Neurology 57 1371-1376 Sorensen TL, Tani M, Jensen J, Pierce V, Lucchinetti C, Folcik VA, Qin S, Rottman J, Sellebjerg F, Strieter RM, Frederiksen JL, Ransohoff RM (1999) Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients. J Clin Invest 103 807-815... [Pg.144]

LEE c-K, KLOPP R G, WEINDRUCH R and PROLLA T A (1999) Gene expression profile of aging and its retardation by caloric restriction. Science 285 1390-93. [Pg.237]

Adjunctive to flux control analysis, other components of metabolism that contribute to product accumulation are needed including (1) substrate/precursor pool sizes (metabolomics), (2) co-factor capacities (metabolomics), (3) gene expression profiles (transcriptomics and quanfifafive real-time PCR), (4) protein profiles (pro-... [Pg.356]

Watanabe N, Ando K, Yoshida S, et al. Gene expression profile analysis of rheumatoid synovial fibroblast cultures revealing the overexpression of genes responsible for tumor-like growth of rheumatoid synovium. Biochem Biophys Res Commun 2002 294(5) 1121-1129. [Pg.195]

Nagase H, Kudo K, Izumi S, et al. Chemokine receptor expression profile of eosinophils at inflamed tissue sites decreased CCR3 and increased CXCR4 expression by lung eosinophils. J Allergy Clin Immunol 2001 108(4) 563-569. [Pg.255]

Fig. 14.1. The Thl/Th2 balance is central to the regulation of normal wound repair. Tissue injury results in the initiation of an inflammatory response, mediated by a variety of cells and their by-products. Immune cells are recruited and cross-regulate the Thl/ Th2 balance that occurs in response to the cytokine environment. This balance is in turn cross-regulated by the chemokine/chemokine-receptor expression profile, which functions to amplify the inflammatory process. Cells residing in the injured tissue release profibrotic mediators, which promote fibroblast activation, proliferation, and differentiation to the myofibroblast phenotype. Myofibroblasts produce collagen to repair damaged tissue, which is an event that is favored by the inhibition of MMP activity. The Thl/Th2 balance is central to whether a normal or aberrant wound-repair process is established A Thl environment promotes normal tissue resolution (fibrinolysis), whereas a Th2 environment maintains the progression of fibrotic disease (excessive collagen deposition). Fig. 14.1. The Thl/Th2 balance is central to the regulation of normal wound repair. Tissue injury results in the initiation of an inflammatory response, mediated by a variety of cells and their by-products. Immune cells are recruited and cross-regulate the Thl/ Th2 balance that occurs in response to the cytokine environment. This balance is in turn cross-regulated by the chemokine/chemokine-receptor expression profile, which functions to amplify the inflammatory process. Cells residing in the injured tissue release profibrotic mediators, which promote fibroblast activation, proliferation, and differentiation to the myofibroblast phenotype. Myofibroblasts produce collagen to repair damaged tissue, which is an event that is favored by the inhibition of MMP activity. The Thl/Th2 balance is central to whether a normal or aberrant wound-repair process is established A Thl environment promotes normal tissue resolution (fibrinolysis), whereas a Th2 environment maintains the progression of fibrotic disease (excessive collagen deposition).
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See also in sourсe #XX -- [ Pg.118 ]

See also in sourсe #XX -- [ Pg.87 ]



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Brain gene expression profile

Breast cancer cells gene expression profiling

Breast cancer expression profiling

Caco gene expression profiling

Cancer expression profiling

Cardiovascular expression profiling

Cell characterization by gene expression profiling

Cellular protein expression profile

Clinical trials gene expression profiling

Clustering expression profiling

Colon cancer expression profiling

Cyclin-dependent kinase gene expression profiling

Differential expression profiles

Drug Targets and Toxicological Profiles by Gene Expression Analysis

Ephrins expression profiles

Ephrins with expression profiles

Escherichia expression profiling

Expressed sequence tags profiling

Expression analysis/profiling

Expression analysis/profiling genome-wide

Expression analysis/profiling research

Expression profiling

Expression profiling

Expression profiling gene)

Expression profiling, microarray

Expression profiling, microarray analysis

Gene expression analyses/profiling

Gene expression profile libraries

Gene expression profiles

Gene expression profiles polymers

Gene expression profiles value

Gene expression profiling development

Gene expression profiling methods

Gene expression profiling using microarrays

Genome expression profiling

Global gene expression profiling

Infectious expression profiling

Inflammation expression profiling

Leukemia expression profiling

Lung cancer expression profiling

Lymphomas expression profiling

MRNA expression profiling

Melanoma expression profiling

MicroRNA expression profiling

Microbe expression profiling

Model for Gene Expression Profiling

Neuronal receptors expression profiles

Pharmacology expression profiling

Primary tumor gene expression profile

Protein expression profiles

Protein expression profiling

Renal cancer expression profiling

Single nucleotide polymorphism SNPs) gene expression profiling

Toxicology expression profiling

Tumor expression profiling

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