Cancer expression profiling

Zom KK, Jazaeri AA, Awtrey CS et al. Choice of normal ovarian control influences determination of differentially expressed genes in ovarian cancer expression profiling studies. Clin Cancer Res 2003 9 4811 818. 

Li Y, Hong X, Hussain M, Sarkar SH, Li R, Sarkar FH. Gene expression profiling revealed novel molecular targets of docetaxel and estramustine combination treatment in prostate cancer cells. Mol Cancer Ther 2005 4 389-98. 

Sandhu, C., Connor, M., Kislinger, T., Slingerland, J., Emili, A. (2005). Global protein shotgun expression profiling of proliferating mcf-7 breast cancer cells. J. Proteome Res. 4,674—689. 

In one recent example of gene expression for pharmacological analysis, Scherf et al. [102] treated 60 different human cancer cell lines with 60,000 compounds. These same 60 cell lines were analyzed by expression analysis [103], and the cell lines were clustered based on expression profiles. The clusters were significantly different from those based on their response to drugs. 

Hedenfalk I et al. Gene expression profiles in hereditary breast cancer. N Engl J Med 2001 344 539-548. 

Sgroi DC et al. In vivo gene expression profile analysis of human breast cancer progression. Cancer Res 1999 59 5656-5661. 

Kudoh K et al. Monitoring the expression profiles of doxorubicin-induced and doxombicin-resistant cancer cells by cDNA microarray. Cancer Res 2000 60 4161-4166. 

Jiang YM, Yamamoto M, Kobayashi Y, Yoshihara T, Liang Y, Terao S, Takeuchi H, Ishigaki S, Katsuno M, Adachi H, Niwa J, Tanaka F, Doyu M, Yoshida M, Hashizume Y, Sobue G (2005) Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis. Ann Neurol 57(2) 236-251 Johnstone RW (2002) Histone-deacetylase inhibitors novel dmgs for the treatment of cancer. Nat Rev Dmg Discov l(4) 287-299... 

Joseph J, Mudduluru G, Antony S, Vashistha S, Ajitkumar P, Somasundaram K (2004) Expression profiling of sodium butyrate (NaB)-treated cells Identification of regulation of genes related to cytokine signaling and cancer metastasis by NaB. Oncogene 23 6304—6315 Kao H-Y, Lee C-H, Komarov A (2002) Isolation and characterization of mammalian HDACIO A novel histone deacetylase. J Biol Chem 277 187-193... 

Luo J, Isaacs WB, Trent JM, Duggan DJ. 2003. Looking beyond morphology cancer gene expression profiling using DNA microarrays. Cancer Invest 21 937. 

Protein expression profiling (protein differential display) using microarrays is considered an important new tool for proteomic discovery. It is similar in concept and approach to the gene expression microarray for mRNA profiling. Sreekumar and Chinnaiyan (2002) describe a general approach for using the microarray to monitor protein expression in cancer and normal tissues. Here are the steps ... 

While the work of Chen et al. (2001) broadly defined the expression of genes associated with metastatic potential in the lung cancer model, others have more narrowly focused upon relationships for specific genes. For example, Pinheiro et al. (2001) examined gene expression profiles from patients... 

Mullan etal. (2001) used an oligonucleotide GUO array (Affymetrix) comprising 6800 genes and ESTs to examine expression profiling in BRCAl-induced cell lines in an effort to identify downstream targets. The GUO array contained approximately 1700 cancer-associated genes. 

Glaser, KB., Staver, M.J., Waring, J.F., Stender, J., Ulrich, R.G. and Davidsen, S.K. (2003) Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines. Molecular Cancer Therapeutics, 2, 151—163. 

Sorensen KD, Orntoft TF (2010) Discovery of prostate cancer biomarkers by microarray gene expression profiling. Expert Rev Mol Diagn 10 49-64... 

Rhodes DR, Kalyana-Sundaram S, Mahavisno V, et al. (2007) Oncomine 3.0 genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles. Neoplasia 9, 166-80. 

N. Raghunand and R. J. Gillies, Characterization of breast cancers and therapy response by MRS and quantitative gene expression profiling in the choline pathway. NMR Biomed., 2009, 22,114-127. 

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