Gene expression profiles polymers

This chapter briefly describes the synthesis of a variety of cationic polymers by LRP and their applications as deojqnribonucleic acid (DNA) and small interfering ribonucleic acid (siRNA) delivery agents. The polymers of different shapes, architectures and molecular weights will be compared for their gene expression profiles. Moreover, the S3mthesis of polymeric... 

Architecture. The advent of LRP has allowed the synthesis of cationic copolymers of well-defined architectures, hence allowing a careful analysis of the structure-activity relationship of these polymers. Synthetic linear cationic glycopolymers of statistical, block and block-statistical architectures were prepared by RAFT polymerization and studied for their gene expression profiles, as a function of molecular weight, carbohydrate content as well as architecture. The copolymers of 30-40 kDa and of... 

This chapter describes the synthesis of a variety of cationic vectors hy ATRP and RAFT polymerization approaches. Owing to the facile synthesis of cationic polymers, libraries of cationic polymers of different types are produced and are evaluated for their gene expression profiles. As discussed above. 

Phenotypic selectivity of polymer-drug formulations for MDR cancers Alteration of signal transduction pathways by polymers in cancer cells Polymer effects on genomic profiles in drug-selected cancer cells. . . Analysis of the effects of polymers on gene expression profiles. Transcriptional activation of gene expression by synthetic polymers. Phenotypic correction of immune response by synthetic polyelectrolytes... 

Analysis of the effects of polymers on gene expression profiles... 

A common concern with synthetic polymers is the inabihty of cells to adequately metabolize the polymer vehicles and constituents that maybe used in their fabrication, such as poly( vinyl alcohol) (PVA), which may comprise nearly 10% w/w of PLGA vehicles [5,24]. Though synthetic polymers provide better sustained release and gene expression profiles than their natural counterparts [5], recognition that in vivo safety is as important as therapeutic success has pushed research efforts toward natural biopolymers in the hopes of achieving true immune transparency [5]. 

Lavigne MD, Pennadam SS, Ellis J et al (2007) Enhanced gene expression through temperature profile-induced variations in molecular architecture of thermoresponsive polymer vectors. J Gene Med 9 44—54... 

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