Lung cancer expression profiling

While the work of Chen et al. (2001) broadly defined the expression of genes associated with metastatic potential in the lung cancer model, others have more narrowly focused upon relationships for specific genes. For example, Pinheiro et al. (2001) examined gene expression profiles from patients... 

Microarray-based gene expression profiling for gene and pathway discovery, functional classification of genes, and new tumor sub-classifications have also been applied to various other malignancies including lung, bladder and prostate cancer, and cutaneous melanoma (reviewed in Refs. 77 80). 

Kikuchi T, Daigo Y, Katagiri T, Tsunoda T, Okada K, Kakiuchi S, Zembutsu H, Furukawa Y, Kawamura M, Kobayashi K, Imai K, Nakamura Y, Expression profiles of nonsmall cell lung cancers on cDNA microarrays Identification of genes for prediction of lymph-node metastasis and sensitivity to anti-cancer drugs, Oncogene, 22 2192-2205, 2003. 

In NSCLC the expression profile of EGFR was correlated with a very poor prognosis and also correlated with stage of disease. One study has documented median survival for 121 patients with squamous cell lung cancer, and patients with expression of EGFR had a shorter survival. ... 

Lung cancer MiR-21, miR-191, miR-210,miR-155,miR-205,miR-24-2,miR-212,miR-214,and miR-17-3 prec up MiR-126,miR-143,miR-192 prec,miR-224,miR-126,miR-30a-5 prec,miR-140,and miR-9da- n Microarray, confirmed by real-time RT-PCR miRNA expression profiles could be diagnostic and prognostic markers of lung cancer 149... 

Volm, M., Koomiigi, R., Mattern, J., and Efferth, T. (2002). Protein expression profiles indicative for drug resistance of non-small cell lung cancer. Br. J. Cancer 87, 251-257. 

Miura, K., Bowman, E.D., Simon, R., Peng, A.C., Robles, A.I., Jones, R.T., Katagiri, T., He, P., Mizukami, H., Charboneau, L., Kikuchi, T., Liotta, L.A., Nakamura, Y., and Harris, C.C. (2002) Laser capture microdissection and microarray expression analysis of lung adenocarcinoma reveals tobacco smoking-and prognosis-related molecular profiles. Cancer Res 62, 3244-50. 

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