Toxicology expression profiling

Toxicology Many companies are known to use gene expression profiling to assess the potential toxicity of lead compounds. This approach may require a database of reference compounds with known pharmacological and toxicological properties. Lead compounds can be compared to the database to predict compound-related or mechanism-related toxicity [5]. 

Fielden MR et al. Challenges and limitations of gene expression profiling in mechanistic and predicitive toxicology. Toxicol Sci 2001 60 6-10. 

Steiner S et al. Expression profiling in toxicology - potentials and limitations. Toxicol Lett 2000 112-113 467 171. 

Zeytun, A., et. al., Analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced gene expression profile in vivo using pathway-specific cDNA arrays, Toxicology, 178, 241, 2002. 

Lung metabolism studies would greatly benefit from the availability of reliable in vitro experimental models that are able to reproduce biochemical and toxicological processes that occur in the human lung. Because of differences in the expression profiles of biotransformation enzymes between animal species, conclusions drawn from experimental animals may not be representative of what occurs in the human lung. 

J.F. Waring, R. Ciurlionis, R.A. Jolly, M. Heindel and R.G. Ulrich, Microarray Analysis of Hepatotoxins in vitro Reveals a Correlation between Gene Expression Profiles and Mechanisms of Toxicity, Toxicology Letters, 2001, 120, 359. 

Although software is plentiful for managing expression profiling data at the laboratory level, there is a great need for public databases that combine profile data with associated biological, chemical, and toxicological endpoints [1], Comparisons of gene, protein, and metabolite data in public databases can be... 

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