Expression analysis/profiling

Gene Expression Analysis. Figure 2 Contribution of gene expression profiling to the drug discovery process. 

In one recent example of gene expression for pharmacological analysis, Scherf et al. [102] treated 60 different human cancer cell lines with 60,000 compounds. These same 60 cell lines were analyzed by expression analysis [103], and the cell lines were clustered based on expression profiles. The clusters were significantly different from those based on their response to drugs. 

Hamadeh, H. K. et al., Gene expression analysis reveals chemical-specific profiles, Toxicol. Sci., 67, 219, 2002. 

S., Martin, K., DiSorbo, O., Sieber, S., Bennett, L., Tennant, R., Stoll, R., Barrett, J.C., Blanchard, K., Paules, R.S. and Afshari, C.A. (2002) Gene expression analysis reveals chemical specific profiles. Toxicological Sciences, 67, 219-231. 

Hamadeh HK, Bushel PR, Jayadev S et al. Gene expression analysis reveals ehemieal-speeific profiles. Toxicol Sci 2002 67 219-231. 

IDENTIFICATION OF DRUG TARGETS AND TOXICOLOGICAL PROFILES BY GENE EXPRESSION ANALYSIS... 

Contact Angle Measurements. Axisymmetric drop shape analysis - profile (ADSA-P) The hydrophobicity/ hydrophilicity of a solid surface is usually expressed in terms of wettability, which can be quantified by contact angle measurements. ADSA-P is a technique to determine liquid-fluid interfacial tensions and contact angles... 

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