Mouse brains

Johnson, J.W., Ascher, P., 1987. Glycine potentiates the NMDA receptor reponse in cultured brain mouse neurones. Nature 325, 529-531. 

Pig brain Cow brain Rat brain Rat brain Rat brain Rat brain Rat brain Mouse brain Rat cortex Rat cortex Rat cortex Rat limbic forebrain Rat limbic forebrain Human hippocampus Rat hippocampus Rat hippocampus Rat hippocampus Rat hippocampus Rat thalamus Rat hypothalamus Rat hypothalamus Rat diencephalon Rat diencephalon Rat striatum Rat striatum Rat striatum Rat mesencephalon Rat midbrain Human cerebellum Rat cerebellum Rat cerebellum Rat cerebellum Rat brainstem Rat brainstem Rat medulla Human pituitary... 

Figure 5.3 (a) In vivo blood vessel biphotonic microscopy imaging of brain mouse, (b) 3D image of chromosomes during cell division by multiphotonic excitation of DAP ... 

Landgrebe J, Welzl G, Metz T et al (2002) Molecular characterisation of antidepressant effects in the mouse brain using gene expression profiling. J Psychiatr Res 36 119-129... 

Leptin is a cytokine produced and secreted by adipose tissue in proportion to the body fat content [3]. Mice and humans lacking leptin or its receptor develop a severe hyperphagia and a dramatic degree of obesity which is considerably more pronounced than that of the NDRKO mouse. Thus, leptin is the key adiposity signal in rodents and humans. Leptin secretion appears to reflect the metabolic status of the adipocyte rather than the sheer size of triglyceride deposits, and leptin levels may transiently be dissociated from total body fat. Nonetheless, over the course of a day with unrestricted food supply, plasma leptin levels reliably reflect the amount of total body fat. Local administration of leptin into the brain results in reduced food intake. The vast majority of patients with obesity have elevated serum levels of leptin. Thus, it is believed that the polygenic obesity is due to leptin resistance rather than to inadequate leptin secretion, or to a reduced blood/brain transport of the cytokine. 

Expression (Mouse) Tissues lungs, Cells myeloid leukocytes, neutrophils, T-cells, macrophages, mast cells, eosinophils Tissues lung, skin, small intestine Cells macrophages, fibroblasts, leukocytes Tissues lung, skin, brain, small intestine, spleen Cells macrophages, fibroblasts, endothelial cells, leukocytes... 

According to the NC-IUPHAR Subcommittee on Opioid Receptois it was proposed to term ORL-1 recqrtor as NOP receptor [1]. The human NOP receptor gene encodes a protein of370 amino acids. Splice valiants have been found in the human and mouse NOP recqrtor with no known functional significance. NOP receptors are widely distributed throughout the brain and in the spinal cord. They are also present in immune cells. A functional role for N/OFQ has been proposed in nociception, locomotoric activity, reward, stress, and immunomodulation. 

Somatostatin. Figure 1 Somatostatin-like im mu noreactivity in neurons of the periventricular hypothalamic nucleus of the rat. Coronal brain cryostat sections have been processed for im mu nohistochemistry and sequentially incubated with a primary monoclonal mouse anti human somatostatin antibody and secondary antimouse antibody conjugated with the fluorescence-dye Cy-3. Images have been taken with a Zeiss Axioplan fluorescence microscope. Scale bar, 100 pM. 

Ryabinin AE, Bachtell RK, Freeman P, et al ITF expression in mouse brain during acquisition of alcohol self-administration. Brain Res 890 192—195, 2001... 

You L, Muralidhara S, Dallas CE Comparisons between operant response and 1,1,1-trichloroethane toxicokinetics in mouse blood and brain. Toxicology 93 151—... 

A key requirement of QSAR is that the compounds used in the modeling and prediction processes should have the same mechanism of action, and for this reason most QSAR studies are made with congeneric series of compounds. However, if a diverse set of compounds can reasonably be assumed to have the same mechanism of action, QSAR modeling can justihably be carried out. For example, Dearden et al. [43] developed a QSAR for the ratio of brain levels of 22 very diverse drugs in the wild-type mouse and the P-glycoprotein knockout mouse (R+/ ) ... 

Pharmacological Methods and Results. The data upon which the following discussion is based were accumulated using three techniques mouse bioassay, displacement of radiolabelled saxitoxin from rabbit brain membranes, and blockage of sodium conductance through rat sarcolemmal sodium channels incorporated into planar lipid bilayers. The results are summarized in Figures 11 and 12. 

Tamplin et. al. (54) observed that V. cholerae and A. hydrophila cell extracts contained substances with TTX-like biological activity in tissue culture assay, counteracting the lethal effect of veratridine on ouabain-treated mouse neuroblastoma cells. Concentrations of TTX-like activity ranged from 5 to 100 ng/L of culture when compared to standard TTX. The same bacterial extracts also displaced radiolabelled STX from rat brain membrane sodium channel receptors and inhibited the compound action potential of frog sciatic nerve. However, the same extracts did not show TTX-like blocking events of sodium current when applied to rat sarcolemmal sodium channels in planar lipid bilayers. 

CTx that has been purified from muscles of Gymnothorax javanicus stimulates the release of neurotransmitters such as 7-aminobutyric acid and dopamine from rat brain nerve terminals. It causes a membrane depolarization of mouse neuroblastoma cells and, under appropriate conditions, it creates spontaneous oscillations of... 

Sanders VJ, Mehta AP, White MG, Achim CL (1998) A murine model of HIV encephalitis xenotransplantation of HIV-infected human neuroglia into SCID mouse brain. Neuropathol Appl Neurobiol 24(6) 461 67... 

---