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Gene expression profiling development

Key Words Toxieogenomics microarray gene expression profile genetic signature drug development biomarker drug resistance... [Pg.340]

A recent paper clearly highlighted the limitations of in vitro systems in modeling whole-organism responses, which should be considered when developing biomarkers of in vivo toxicity. Dere and colleagues (58) compared the temporal gene expression profiles of Hepalclc mouse hepatoma cells and of the mice liver after treatment with a dioxin. The analysis revealed that Hepalclc cells were able to model the induction of xenobiotic metabolism in vivo. On the other hand, responses associated with cell cycle progression and proliferation were unique to the in vitro system, while lipid metabolism and immune responses were not replicated effectively in the Hepalclc cells. [Pg.346]

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Expression profile

Expression profiling

Expression profiling gene)

Gene expression development

Gene expression profiles