Leukemia expression profiling

Balabanov S, Bartolovic K, Komor M et al. Gene expression profiling of normal hematopoietic progenitor cells under treatment with imatinib in vitro. Leukemia 2005 19 1483 1485. 

Yu J, Wang F, Yang GH et al. Human mieroRNA clusters genomic organization and expression profile in leukemia cell lines. Biochem Biophys Res Commun 2006 349 59-68. 

Valk PJ, Verhaak RG, Beijen MA, Erpelinck CA, Barjesteh van Waalwijk van Doorn-Khosrovani S, et al. Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med 2004 350(16) 1617-1628. 

Dunphy CH. Gene expression profiling data in lymphoma and leukemia Review of the literature and extrapolation of pertinent clinical applications. Arch Pathol Lab Med 2006 130(4) 483-520. 

Wilson CS, Davidson GS, Martin SB et al. Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome prediction. Blood 2006 ... 

Ross ME, Zhou X, Song G ct aL Classification of pediatric acute lymphoblastic leukemia by ne expression profiling. Blood 2003 102(8) 2951-2959. 

Wiestner A, Rosenwald A, Barry TS, et al. ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with tmmu-tated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile. Blood. 2003 101(12) 4944-4951. 

Villuendes R, Steegmann J L, Polldn M, et al. (2006). Identification of genes involved in imatinib resistance in CML a gene-expression profiling approach. Leukemia. 20 1047-1054. 

Efferth T, Gillet JP, Sauerbrey A, Bertholet V, de Longueville FO, Remade J, Steinbach D. Expression profiling of ATP-binding cassette transporters in childhood T-cell acute lymphoblastic leukemia. Mol Cancer Ther 2006 5 1986-1994. 

Zanette DL, Rivadavia F, Molfetta GA, Barbuzano FG, Proto-Siqueira R, Falcao RP, Zago MA, Silva-Jr WA 2007. miRNA expression profiles in chronic lymphocytic and acute lymphocytic leukemia. Braz J Med Biol Res 40(11) 1435-1440. 

Lee, S., et al.. Gene expression profiles in acute myeloid leukemia with conunon translocations using SAGE, Proc Natl Acad Sci USA, 103,1030, 2006. 

The C-Map data are freely available and have been used in other studies since the original publication in 2006 these studies include the search for novel antivirals for influenza (15) and the discovery of synergistic drug combination therapies for treating acute myeloid leukemia (16). The current (2011) C-Map data are based on 7,000 expression profiles representing 1,309 compounds (17). 

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