Inflamed tissue

Open surgical arthroscopic synovectomy reduces replacement-therapy-resistant disease and repetitive hemarthresis of a single joint. This procedure removes inflamed tissue and joint blood vessels. 

Caseating granulomas A mass or nodule of chronically inflamed tissue with granulations, usually associated with an infective process. 

Sarcoidosis An inflammatory disease characterized by granulomas (masses of chronically inflamed tissues with granulations) that can produce many different symptoms. 

In contrast with mDCs, which are clearly primed by antigens at local inflamed tissues (Figs. 1 and 2), the site of pDC priming is not fully established. We consider that an activated HEV cell is a good candidate to create primed pDCs (13). Because naive pDC precursors preferentially bind to activated, but not... 

DARC Synovium EC (venules only) Possible role in transmigration of cells from blood to inflamed tissue Northern, IHC 185, 186... 

Nagase H, Kudo K, Izumi S, et al. Chemokine receptor expression profile of eosinophils at inflamed tissue sites decreased CCR3 and increased CXCR4 expression by lung eosinophils. J Allergy Clin Immunol 2001 108(4) 563-569. 

LS and CLS are solid microparticles with a mean diameter usually between 0.2 and 500 pm, composed of a solid hydrophobic fat matrix in which (in the case of LS) the bioactive compound or compounds are dissolved or dispersed. Because of their large range in particle size, LS can be administered by different routes, such as orally, subcutaneously, intramuscularly, or topically, or they can be used for cell encapsulation, thus allowing them to be proposed for treatment of a number of diseases [26-28], The in vivo distribution of LS demonstrated a high affinity to vascular wells (including capillaries), to inflamed tissues, and to granulocytes [29,30],... 

With the advent of modern medical principles, the medical usage of leeches waned somewhat. In more recent years, however, they did stage a limited comeback. They were occasionally used to drain blood from inflamed tissue, and in procedures associated with plastic surgery. 

A primary mechanism of injury with sepsis is through endothelial cells. With inflammation, endothelial cells allow circulating cells (e.g., granulocytes) and plasma constituents to enter inflamed tissues, which may result in organ damage. 

Invasion of the tissues by an infective agent initiates an inflammatory response in the animal. This is non-specific and is mediated primarily by substances released from tissues that are damaged as a result of either trauma or the toxic effects of the infective agent. The major mediator is the vasoactive amine histamine, which causes an increased local blood flow and capillary permeability, resulting in local oedema. A major aspect of the inflammatory response is the involvement of large numbers of phagocytic cells, particularly the polymorphonuclear leucocytes. These are chemotactically attracted to the inflamed tissues and are mainly responsible for the elimination of particulate material. This often results in the destruction of many of these cells and the formation of pus. 

Ring S, Schafer SC, Mahnke K, Lehr HA, Enk AH CD4+ CD25+ regula- 41 tory T cells suppress contact hypersensitivity reactions by blocking influx of effector T cells into inflamed tissue. 

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