Pharmacology expression profiling

Toxicology Many companies are known to use gene expression profiling to assess the potential toxicity of lead compounds. This approach may require a database of reference compounds with known pharmacological and toxicological properties. Lead compounds can be compared to the database to predict compound-related or mechanism-related toxicity [5]. 

In one recent example of gene expression for pharmacological analysis, Scherf et al. [102] treated 60 different human cancer cell lines with 60,000 compounds. These same 60 cell lines were analyzed by expression analysis [103], and the cell lines were clustered based on expression profiles. The clusters were significantly different from those based on their response to drugs. 

Drugmatrix Pharmacological, pathology and gene expression profiles for benchmark drugs http //www.iconixpharm.com... 

Terada, T., Shimada, Y., Pan, X., Kishimoto, K., Sakurai, T., Doi, R., Onodera, H., Katsura, T., Imamura, M. and Inui, K. (2005) Expression profiles of various transporters for oligopeptides, amino acids and organic ions along the human digestive tract. Biochemical Pharmacology, 70 (12), 1756-1763. 

Waring, J. E., R. A. Jolly, R. Ciurlionis, P. Lum, J. T. Praestgaard, D. C. Morfitt, B. Buratto, C. Roberts, E. Schadt, and R. G. Ulrich. 2001. Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles. Toxicology and Applied Pharmacology 175 28-42. 

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