Erythema multiforme

Pemphigus, bullous dermatitis herpetiformis, severe erythema multiforme (Stevens-Johnson syndrome), exfoliative dermatitis, mycosis fungoides, severe psoriasis, severe seborrheic dermatitis, angioedema, urticaria, various skin disorders, such as lichen planus or keloids... 

Rhinitis (sneezing, rhinorrhea) Erythema multiforme minor... 

NSAIDs can induce a number of other adverse reactions, including bleeding disorders, anemia, thrombocytopenia, erythema nodosum, erythema multiforme, fixed drug eruptions, toxic epidermal necrolysis, Stevens-Johnson syndrome, leukocytocla-sitc vasculitis, recurrent fever with exanthema and, of course, the well-known gastric cytotoxicity. 

Erythema multiforme/Stevens-Johnson syndrome/toxic epidermal necrolysis... 

The most frequent adverse effects are local reactions at the injection site (pain, tenderness, erythema, swelling, and pruritus), fevers (greater than 37.5°C or 99.5°F), headaches, dizziness, and irritability. Anaphylaxis and hypersensitivity reactions have been reported rarely and occur within a few hours after vaccine administration. In rare instances, a serum sickness-like apparent hypersensitivity syndrome (arthralgia, urticaria, ecchymoses, erythema multiforme, and erythema nodosum) has been... 

Erythema multiforme—a rash characterized by papular (small raised bump) or vesicular lesions (blisters) and reddening or discoloration of the skin often in concentric zones about the lesion. 

Stevens-Johnson syndrome—a severe expression of erythema multiforme (also known as erythema multiforme major). It typically involves the skin and the mucous membranes with the potential for severe morbidity and even death. 

Delayed reactions with radiocontrast media occur in 1% to 3% of patients.21 Although reactions occasionally are severe, most are mild and manifest as maculopapular rashes, fixed eruptions, erythema multiforme, and urticarial eruptions. 

Some regimens are designed for outpatient administration over much longer time periods and have been used, for example, with allopurinol dermal reactions. Such late-onset morbiliform reactions, sometimes overlapping with erythema multiforme minor, are difficult to evaluate because it is often unclear to what extent the patients were at risk for recurrent reaction. 

Erythema multiforme Target lesions, limbs Absent Anticonvulsants (including lamolrigine), sulfonamide antibiotics, allopurinol, NSAIDs, dapsone Supportive0... 

Valley fever is a syndrome characterized by erythema nodosum and erythema multiforme of the upper trunk and extremities in association with diffuse joint aches or fever. Valley fever occurs in approximately 25% of infected persons, although, more commonly, a diffuse mild erythroderma or maculopapular rash is observed. 

Septra DS Septra SS Antibiotic Tab Sulfamethoxazole 800 mg, trimethoprim 160 rrg Tab Sulfamethoxazole 400 mg, trimethoprim 80 mg Urinary tract infections 1 tab bid x 7-10 days Shigellosis 1 lab bid x 3-5 days Bronchitis 1 tab bid x 2 weeks Travelers diarrhea 1 tab bid x 5 days Rash common Stevens Johnson Syndrome (erythema multiforme) rarely UTI Prophylaxis 1 tabqhs... 

Dermatologic diseases Pemphigus bullous dermatitis herpetiformis severe erythema multiforme (Stevens-Johnson syndrome) mycosis fungoides severe psoriasis angioedema or urticaria exfoliative, severe seborrheic, contact, or atopic dermatitis. 

CNS Convulsions weakness malaise fatigue nervousness drowsiness depression dizziness disorientation confusion ataxia tremor tinnitus headache. Dermatologic Urticaria pruritus skin eruptions rash (including erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis) photosensitivity. 

Adverse reactions may include drowsiness ataxia dizziness slurred speech headache vertigo weakness impairment of visual accommodation euphoria overstimulation paradoxical excitement nausea vomiting diarrhea palpitations tachycardia various arrhythmias syncope hypotensive crises allergic/idiosyncratic reactions leukopenia acute nonthrombocytopenic purpura petechiae ecchymoses eosinophilia peripheral edema fever hyperpyrexia chills angioneurotic edema bronchospasm oliguria anuria anaphylaxis erythema multiforme exfoliative dermatitis stomatitis proctitis Stevens-Johnson syndrome bullous dermatitis paresthesias agranulocytosis aplastic anemia thrombocytopenic purpura. 

Allergic symptoms include urticaria angioneurotic edema laryngospasm bronchospasm hypotension vascular collapse death maculopapular to exfoliative dermatitis vesicular eruptions erythema multiforme reactions resembling serum sickness (eg, chills, fever, edema, arthralgia, arthritis, malaise) laryngeal edema skin rashes prostration. 

Serum sickness-like reactions (erythema multiforme or skin rashes accompanied by polyarthritis, arthralgia and, frequently, fever) have been reported these reactions usually occurred following a second course of therapy. Signs and symptoms occur after a few days of therapy and resolve a few days after drug discontinuation with no serious sequelae. 

Dermafo/og/c. Alopecia, balanitis, erythema multiforme, erythema nodosum, fixed drug eruptions, hyperpigmentation of the nails, injection site erythema and injection site pain, maculopapular and erythematous rashes, photosensitivity, pruritus, skin and mucus membrane pigmentation, Stevens-Johnson syndrome, toxic epidermal necrolysis, vasculitis. 

Nausea vomiting diarrhea (clindamycin 3.4% to 30%) pseudomembranous colitis (clindamycin 0.01% to 10% 3 to 4 times more frequent with oral administration) neutropenia (sometimes transient) leukopenia agranulocytosis thrombocytopenic purpura skin rashes, urticaria, erythema multiforme anaphylaxis jaundice liver function test abnormalities (serum transaminase elevations). 

CNS - Asthenia, confusion, depression, dizziness, drowsiness, headache, nystagmus, peripheral neuropathy (see Warnings), psychotic reactions, vertigo. Dermatologic Erythema multiforme (including Stevens-Johnson syndrome), exfoliative dermatitis (rare) transient alopecia. 

Rash In controlled clinical trials, rash occurred in 21% of patients treated with atazanavir. Discontinue atazanavir if severe rash develops. Cases of Stevens-Johnson syndrome and erythema multiforme have been reported in patients receiving atazanavir. 

Skin - Severe, occasionally fatal dermatologic reactions, including toxic epidermal necrolysis, Stevens-Johnson syndrome, exfoliative dermatitis, skin necrosis, and erythema multiforme, have been reported within days of methotrexate administration. 

Less frequent are skin rashes, tinnitus and liver function disturbances. Erythema multiforme and Stevens-Johnson syndrome have been reported. 

Hepatic failure, severe rash, hemolytic anemia, rhabdomyolysis, erythema multiforme, Stevens-lohnson syndrome, and acute kidney failure have been reported. 

Abnormal hepatic function, including jaundice, hepatitis, and hepatic necrosis alopecia anaphylaxis breast enlargement erythema multiforme peripheral edema and seizures have been reported. 

Hypersensitivity reactions, Stevens-fohnson syndrome, toxic epidermal necrolysis, erythema multiforme, anaphylaxis, hyperphenylalaninemia, megaloblastic anemia, leukopenia, thrombocytopenia, pancytopenia, atrophicglossitis, hematuria, and disorders of cardiac rhythm Rare... 

Unlabeled Uses Prevention and treatment of discoid lupus erythematosus, erythema multiforme, graft vs host reactions following bone marrow transplantation, rheumatoid arthritis treatment of Behget s syndrome, Crohn s disease, G1 bleeding, multiple myeloma, pruritus, recurrent aphthous ulcers in HIV patients, wasting syndrome associated with HIV or cancer... 

Erythema multiforme, liver damage Serious Reactions... 

Stevens-Johnson syndrome, erythema multiforme, exfoliative dermatitis, and anaphylaxis occur rarely. 

A variety of relatively uncommon dermatological side effects have been noted to be associated with antipsychotic agents. These include maculopapular rashes, urticaria, and erythema multiforme (Arana, 2000). Photosensitivity and skin pigmentation can also occur during treatment with these drugs. Although skin pigmentation has been most frequently reported with chlorpromazine, this can occur with thioridazine and trifluoperazine (Harth and Rapoport, 1996). In addition, treatment-induced alopecia has been reported for haloperidol, olanzapine, and risperidone (Mercke et ah, 2000). 

An exanthematous rash is one of the more common side effects of carbamazepine, occurring in 3%-17% of patients. This reaction typically begins within 2-20 weeks after the start of treatment. Car-bamazepine is generally discontinued if a rash develops because of the risk of progression to an exfoliative dermatitis or Stevens-Johnson syndrome, a severe bullous form of erythema multiforme. 

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