Skin pigmentation

Haut-entglftungsmlttel, n. skin decontaminant, -entgiftungssalbe, /. decontaminating ointment. -farbe, /. color of the skin, -farb-stoff, m. skin pigment, -gift, n. (Mil.) skin poison, vesicant. 

I have been advised that exposure to sun must be avoided at all costs for a period of 6 months. No sunbathing is permitted for 6 months. To do so would encourage blotchy skin pigmentation requiring further treatment. 

Hydroxychloroquine 200 mg bid Oral 8-24 weeks N, D, HA, vision changes, skin pigmentation Eye exam every 12 mo. ... 

Figure 9.7 UV-visible spectrum of the skin pigment melanin. The spectrum contains two traces (a) eumelanin and (b) pheomelanin. Both component compounds protect the skin by absorbing harmful UV light. All pigment concentrations were 1 mgdm 3...

CX is very different from other blister agents in that it attacks whatever tissue it contacts, such as skin, muscle, and nerves. Its impact on nerves is intense unremitting pain. When CX comes in contact with skin, it leaves a blanched area (bleached appearance) within 30 seconds where it has been absorbed into the skin. A red rash-like ring immediately forms around the affected area. Within a day, the blanched area and rash will turn dark as broken-down skin pigment pools near the surface. A scab will form over the area in about a week. This scab will fall off approximately 3 weeks later. Immediate death from systemic shock or trauma is possible. Healing may take as long as 1 year in severe cases. 

No studies were located regarding immunological effects in humans after oral exposure to 1,4-dichlorobenzene. S5mimetrical lesions with a bizarre pattern of skin pigmentation over most of her body were reported in the case study of a 19-year-old black woman who ingested 4-5 moth pellets of 1,4-dichloro-... 

Clofazimine is a dye with bactericidal activity against M. leprae and antiinflammatory properties. It is given orally, but is incompletely absorbed. Because of its high lipophilicity, it accumulates in adipose and other tissues and leaves the body only rather slowly (ti/2 - 70 d). Red-brown skin pigmentation is an unwanted effect, particularly in fair-skinned patients. 

At least two colored melanins are formed—a series of black melanins and a series of so-called red melanins. Our skin pigmentation is determined by the relative amounts of these red and black melanins. 

Minocycline is frequently used in the treatment of chronic facial dermatoses. Increased usage has resulted in local skin pigmentation, particularly at sites of previous tissue trauma that is unrelated to the photosensitization phenomenon characteristic of this class of drug. This effect does not appear to be dose dependent and usually resolves in months to years following drug discontinuation. 

A 68-year-old white South African man receiving treatment for lepromatous leprosy has increasing red-brown pigmentation. Which of the following antileprosy drugs is responsible for the patient s skin pigmentation ... 

At usual therapeutic dosages, busulfan is selectively toxic to granulocyte precursors rather than lymphocytes. Thrombocytopenia and anemia and less commonly, nausea, alopecia, mucositis, and sterility also may occur. Unusual side effects of busulfan include gynecomastia, a general increase in skin pigmentation, and interstitial pulmonary fibrosis. 

The toxicities of 5-fluorouracil vary with the schedule and mode of administration. Nausea is usually mild if it occurs at all. Myelosuppression is most severe after intravenous bolus administration, with leukopenia and thrombocytopenia appearing 7 to 14 days after an injection. Daily injection or continuous infusion is most likely to produce oral mucositis, pharyngitis, diarrhea, and alopecia. Skin rashes and nail discoloration have been reported, as have photosensitivity and increased skin pigmentation on sun exposure. Neurological toxicity is manifested as acute cerebellar ataxia that may occur within a few days of beginning treatment. 

Ocular changes, altered skin pigmentation (with prolonged use of high doses)... 

Edema, weight gain or loss, rash, pruritus, photosensitivity skin pigmentation Rare... 

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