Injection site pain

Hot flushes, skeletal pain, injection site pain, hypertension, headache, insomnia, dizziness, vomiting, diarrhea, impotence... 

The most frequent adverse effects are local reactions at the injection site (pain, tenderness, erythema, swelling, and pruritus), fevers (greater than 37.5°C or 99.5°F), headaches, dizziness, and irritability. Anaphylaxis and hypersensitivity reactions have been reported rarely and occur within a few hours after vaccine administration. In rare instances, a serum sickness-like apparent hypersensitivity syndrome (arthralgia, urticaria, ecchymoses, erythema multiforme, and erythema nodosum) has been... 

Etomidate Inhibits 1 7, 20-lyase, 6 g/day Limited clinical hypokalemia, edema, hypertension. Injection-site pain, aminoglutethimide if used in combination. Intravenous route of administration... 

Octreotide Long-acting 300-1200 mcg/day Injection site pain, Most useful in Nelson s syndrome... 

Vitamin B12 generally is well tolerated and exhibits minimal adverse effects. Injection-site pain, pruritus, rash, and diarrhea have been reported. Drug interactions have been observed with omeprazole and ascorbic acid that decrease oral absorption. 

Parenteral iron anaphylaxis (test dose required for iron dextran and observe for 1 hour after), injection-site pain/ irritation, arthralgias, myalgias, flushing, malaise, and fever... 

Alefacept (Amevive) is a dimeric fusion protein that binds to CD2 on T cells to inhibit cutaneous T-cell activation and proliferation. It also produces a dose-dependent decrease in circulating total lymphocytes. Alefacept is approved for treatment of moderate to severe plaque psoriasis and is also effective for treatment of psoriatic arthritis. Significant response is usually achieved after about 3 months of therapy. The recommended dose is 15 mg intramuscularly once weekly for 12 weeks. Adverse effects are mild and include pharyngitis, flu-like symptoms, chills, dizziness, nausea, headache, injection site pain and inflammation, and nonspecific infection. 

Adverse reactions may include death, convulsions, headache, injection site pain, increased sweating, fatigue, cutaneous vasodilation, nausea, vomiting, dizziness, agitation, dry mouth, tremors, palpitations, insomnia, dyspnea, hyperventilation, emotional lability, abnormal/blurred vision, and paresthesia. 

Unlabeled uses Prophylactic APAP use in children receiving DTP vaccination appears to decrease incidence of fever and injection site pain. A dose immediately following vaccination and every 4 to 6 h thereafter for 48 to 72 h is suggested. 

Primary axillary hyperhidrosis Adverse events (in at least 3% of patients) included injection site pain and hemorrhage, nonaxillary sweating, infection, pharyngitis, flu syndrome, headache, fever, neck or back pain, pruritus, and anxiety. Blepharospasm The most frequently reported treatment-related adverse reactions were ptosis (20.8%), superficial punctate keratitis (6.3%), and eye dryness (6.3%). Strabismus Extraocular muscles adjacent to the injection site can be affected, causing ptosis, vertical deviation, spatial disorientation, double vision, or past-pointing, especially with higher doses of botulinum toxin type A. 

Dermafo/og/c. Alopecia, balanitis, erythema multiforme, erythema nodosum, fixed drug eruptions, hyperpigmentation of the nails, injection site erythema and injection site pain, maculopapular and erythematous rashes, photosensitivity, pruritus, skin and mucus membrane pigmentation, Stevens-Johnson syndrome, toxic epidermal necrolysis, vasculitis. 

Injection site pain and inflammation (with IM administration)... 

Injection site pain, insomnia, hypertension, anxiety, vomiting, pelvic or abdominal pain, bradycardia, nervousness, dyspepsia, fever, urine retenfion... 

Headache, chills, nausea, injection site pain Occasional (8%-7%)... 

Injection site pain, constipation, diarrhea, abdominal pain, anorexia, dizziness, insomnia, paresthesia, bone or back pain, depression, anxiety, peripheral edema, rash, diaphoresis, fever Rare(2%-1%)... 

Notify the physician of side effects, including headache or injection site pain, as soon as possible... 

Decreased respiratory rate, tenderness at IM or IV injection site, pain during injection, oxygen desaturation, hiccups... 

Rash, pruritus, altered vision, headache, nausea, vomiting, injection site pain and... 

Orthostatic hypotension, hyperglycemia, glycosuria, hyperuricemia, muscle spasm, weakness, restlessness, urinar y bladder spasm, thrombophlebitis, IM injection site pain, fever... 

A review of octreotide LAR has suggested that the most common adverse effects are gastrointestinal effects and injection site reactions (4). Injection site pain is also common and dose related. The cardiovascular, biliary, and glucose metabolism effects were also reviewed. 

Bloch Y, Levkovitz Y, Atshuler A, et al. Use of topical application of lidocaine-prilocaine cream to reduce injection-site pain of depot antipsychotics. Psychiatr Serv. 2004 55 940-941. 

Intravenous GHRH usually causes acute but transient adverse effects lasting several minutes. These effects include flushing, injection site pain and erythema, nausea, headache, metallic taste, pallor, and chest tightness. 

As per BNF, side-effects of hydroxocobalamin are nausea, headache, dizziness, fever, hypersensitivity reactions including rash and pruritus, injection-site pain, and hypokalaemia during initial treatment. 

Published and unpublished studies from 1995 to 2004, in which intramuscular ziprasidone was assessed, have been reviewed (9). The most common adverse events in the 921 patients were nausea, headache, dizziness, anxiety, somnolence, insomnia, and injection-site pain 1.1 to 6.1% withdrew because of treatment-related adverse events. 

Dermatologic Injection site pain, erythema multiforme... 

Dizziness, injection site pain, sweating, headache, blurred vision... 

The safety profiles of epoetin and darbepoetin are similar. Adverse effects of darbepoetin include hypertension, injection site pain (generally mild and transient) in the case of subcutaneous administration, cardiovascular events, headache, vascular disorders (vascular access thrombosis), flu-like sjmptoms, and skin rashes (20,53,54). Adverse effects such as hypertension and thrombophlebitis are observed in uremic patients requiring dialysis but not in patients with hematological malignancies (55). 

Other local reactions hematoma, injection site pain, local maculopapular rash, local heat. 

Phenytoin is the only widely used hydantoin and, unless otherwise specified, effects discussed here refer to phenytoin. Other hydantoin derivatives include ethotoin (rINN), mephenytoin (rINN), and albutoin (rINN) (all of which are obsolete), and fosphenytoin (rINN). The latter is a water-soluble prodrug that is rapidly hydrolysed to phenytoin after intravenous or intramuscular injection. It causes fewer adverse reactions near the injection site (pain, phlebitis, tissue necrosis, purple hand syndrome) than phenytoin. 

A double-blind, placebo-controUed evaluation of perflenapent emulsion as a contrast agent for the liver, kidneys, and vasculature has been reported in 151 patients of whom 12 had adverse effects compared with nine who received placebo (12). Injection site pain, vasodilatation, rash, and rhinitis occurred more often with perflenapent than placebo. 

In 1995, live virus Varicella vaccine (Oka strain) was licensed in the USA. Of the 6574 reported adverse events 4% (67.5 per 100 000 doses) after immunization were serious, while the majority were minor reactions, such as rash, redness, or injection site pain (9). About 10% of immunized children developed mild chickenpox. A total 193 vaccinees reported neurological symptoms, including Bell s palsy, convulsions, and demyelinating syndromes febrile seizures accounted for half of the cases of convulsions. There were 14 deaths, but a role for the vaccine was not proven. 

N/V, dizziness, injection site pain. Cardiovascular coronary vasospasm, chest pain, ischemic Ml. 

As a class, the interferons possess some common side cITects. These arc flu-like symptoms, headache, fever, muscle aches, buck pain, chills, nausea and vomiting, and diarrhea. At the injection site. pain, edema, hemorrliage. and inflammation are common. Dizziness is also commonly reported. 

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