Purpura thrombocytopenic

Hematologic diseases autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura, pernicous anemia Kidney disease Goodpasture syndrom, lipoid nephroses, minimal change glomerulonephritis Diseases of the gastrointestinal tract autoimmune chronic active hepatitis, autoimmune atrophic gastritis, Crohn s disease, ulcerative colitis... 

Thrombopoietic factors (no recombinant TPO product in clinical use at this time IL-11 [recombinant product oprelvekin] has marketing approval) stimulate the production of megakaryocyte precursors, megakaryocytes, and platelets [8]. Interleukin-11 has many effects on multiple tissues, and can interact with IL-3, TPO, and SCF. AMG 531, a recombinant peptibody in that binds to the thrombopoetin receptor Mpl and stimulates the production of platelets, is in phase 1 and 2 studies and has been shown to safely increase platelet counts in patients with immune thrombocytopenic purpura [9]. 

Idiopathic or secondary thrombocytopenic purpura, hemolytic anemia, red blood cell anemia, congenital hypoplastic anemia... 

Suppression of Rh isoimmunization in non sensitized Rh (D)-negative women, immune thrombocytopenic purpura, transfusion to suppress Rh isoimmunization in Rh (D)-negative female children and female adults in their childbearing years... 

Ticlopidine inhibits the P2Yj2 platelet ADP receptor, thus inhibiting ADP-dependent activation of the GP Ilb/IIIa receptor. It has a slow onset of action and takes 3-7 days to reach its maximal antiplatelet effect. It is inactive in vitro and must undergo activation by the hepatic cytochrome p450 enzyme system. Secondary prevention trials have found that ticlopidine-treated patients have an estimated RRR of 33% for the composite endpoint of stroke, myocardial infarction, or vascular death after ischemic stroke. Significant adverse effects include bone marrow depression, rash, diarrhea, and thrombotic thrombocytopenic purpura. No clinical trials have studied ticlopidine for the treatment of stroke in the acute phase. 

ACE, angiotensin-converting enzyme aPTT, activated partial thromboplastin time ARB, angiotensin receptor blocker BP, blood pressure CBC, complete blood count ECC, electrocardiogram HR, heart rate INR, International Normalized Ratio RR, respiratory rate SCr, serum creatinine, TTP, thrombotic thrombocytopenic purpura. 

Hematologic von Willebrand disease Idiopathic thrombocytopenic purpura Factor VII defect causing impaired platelet adhesion and increased bleeding time Decrease in circulating platelets—can be acute or chronic... 

Recommend treatment approach for the initial treatment of immune thrombocytopenic purpura (UP). 

Identify basic clinical features of thrombotic thrombocytopenic purpura (TTP). 

Thrombotic thrombocytopenic purpura (TTP) is a severe systemic disorder characterized by the thrombi formation within the circulation that result in the platelet consumption and subsequent thrombocytopenia. The inherited sub-type is chronic and relapsing and generally occurs in childhood. Acute idiopathic TTP, which occurs in adults, is more common and harder to treat. The estimated annual incidence of TTP is 3.7 cases per million.33... 

EHEC are the pathogenic subgroup of Stx-producing E. coli (STEC). Acute hemorrhagic colitis has been associated mainly with the 0157 H7 serotype. This serotype has been responsible for larger outbreaks of infection, has higher rates of complications, and appears to be more pathogenic than non-EHEC STEC strains. The spectrum of disease associated with E. coli 0157 H7 includes bloody diarrhea, which is seen in as many as 95% of patients, nonbloody diarrhea, hemolytic-uremic syndrome (HUS), and thrombotic thrombocytopenic purpura. 

Acyclovir 200 mg PO q4hour x 7-/0 days 400 mg PO 3 times daily x 7-10 days3 200 mg PO q12hour x 7-1 0 days6 Headache, confusion, nausea, vomiting, thrombocytopenia, renal insufficiency, rash, pruritus, fever, arthralgias, myalgia, thrombotic thrombocytopenic purpura, hallucinations, somnolence, depression... 

HBP High blood pressure ITP Idiopathic thrombocytopenic purpura... 

Thrombotic thrombocytopenic purpura Condition characterized by formation of small clots within the circulation resulting in the consumption of platelets and a low platelet count. 

Mortality Rate (untreated) <0.5% overall <15% hemolytic uremic syndrome <99% for thrombotic thrombocytopenic purpura. 

Suggested Alternatives for Differential Diagnosis Malaria, typhoid fever, shigellosis, meningococcemia, salmonella infection, other tick-borne diseases, rickettsial infections, leukemia, lupus, disseminated intravascular coagulation, hemolytic uremic syndrome, leptospirosis, thrombocytopenic purpura, and idiopathic or thrombotic thrombocytopenic purpura. 

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