Bone marrow transplant

GM-CSF, G-CSF, M-CSF, multi-CSF cytotoxic injury bone marrow transplantation myelodysplastic syndromes AIDS neutropenia rodent and human... 

The first human kidney and bone marrow transplants using cyclosporine were reported in 1978. Oral or intravenous cyclosporine is an immunosuppressant for transplantation of these and other organs and investigations are underway for its possible use in a variety of autoimmune diseases including rheumatoid arthritis, severe psoriasis, and Crohn s disease. Dose-dependent nephrotoxicity (261—264) remains the primary limitation of the dmg and necessitates close monitoring of patients, including measurement of dmg levels in blood. Cyclosporine research has been reviewed (265—274). 

Acyclovir is more effective the more serious the disease and the earher it is given. It has been shown to be efficacious when used systemicaHy in the prophylaxis of HSV infections in immunosuppressed patients, ie, bone marrow transplant recipients (67). Acyclovir therapy appears to be superior to ara-A in the treatment of herpes simplex encephaUtis in humans (68). 

Treatment for chronic benzene poisoning is supportive and symptomatic, with chemotherapy and bone marrow transplants as therapeutic agents for leukemia and aplastic anemia (127). 

This is a humanized anti-CD52 monoclonal antibody. At present it is in clinical use after bone marrow transplantation and for the treatment of refractory chronic lymphocytic leukemia. 

Kitamura Y, Go S, Hatanaka K Decrease of mast cells in W/W" mice and their increase by bone marrow transplantation. Blood 1978 52 447-452. Grimbaldeston MA, Chen CC. Piliponsky AM, Tsai M. Tam SY, Galh SJ Mast cell-deficient W-sash c-kit mutant mice as a model for investigating... 

Granulocyte-macrophage colony stimulating factor 127 amino acids E. coll Improved bone marrow transplant Approved for sale... 

Cyclosporine and tacrolimus are calcineurin inhibitors that are administered as part of immunosuppressive regimens in kidney, liver, heart, lung, and bone marrow transplant recipients. In addition, they are used in autoimmune disorders such as psoriasis and multiple sclerosis. The pathophysiologic mechanism for ARF is renal vascular vasoconstriction.41 It often occurs within the first 6 to 12 months of treatment, and can be reversible with dose reduction or drug discontinuation. Risk factors include high dose, elevated trough blood concentrations, increased age, and concomitant therapy with other nephrotoxic drugs.41 Cyclosporine and tacrolimus are extensively metabolized by... 

Measles, mumps, and rubella vaccine is a live virus vaccine that should be used with caution in immunosuppressed children, such as those with cancer receiving chemotherapy, solid organ or bone marrow transplantation, or receiving other immunosuppressive drugs, such as steroids in a dose... 

A 7-year-old child with acute leukemia is 1 year post-bone marrow transplantation. The child s clinical course has been uneventful since transplantation and everything is going as expected. The physician discusses with the child s parents the continued need for protection against infections and suggests that the child should receive some vaccinations. 

The number of immunocompromised persons is continually increasing as advances are made in medicine. The life expectancy for persons with cancer, HIV infection, and solid organ or bone marrow transplantation is increasing. Vaccination provides one tool to prevent infection in the immunocompromised host however, the individual s immuno-suppressed state will alter the response to vaccine. In general all vaccinations should be updated prior to the person becoming immunosuppressed, if possible. Once a person becomes significantly immunosuppressed, live virus vaccines should be avoided. 

JP is receiving a highly myelosuppressive chemotherapy regimen for the next 3 days for his lymphoma. The chemotherapy orders specify ifosfamide, carboplatin, and etoposide. The goal of this cycle of chemotherapy is to put the cancer into remission so that his lymphoma can be cured with a bone marrow transplant. 

Thierry P, Guglielmi C, Hagenbeek A, et al. Autologous bone marrow transplant as compared with salvage chemotherapy in relapses... 

Close monitoring of HCT recipients for infections is necessary because recovery of immune function is slow, sometimes requiring over 2 years, even in the absence of immunosupressants.104 Fevers should be assessed and treated rapidly to minimize the likelihood of a fatal infection. HCT recipients—both autologous and allogeneic—lose protective antibodies to vaccine-preventable diseases the CDC and the European Group for Bone Marrow Transplantation have issued recommendations for reimmunization for HCT recipients.107... 

Anonymous. Allogeneic peripheral blood stem-cell compared with bone marrow transplantation in the management of hematologic malignancies An individual patient data meta-analysis of nine randomized trials. J Clin Oncol 2005 23 5074-5087. 

Leather HL. Drug interactions in the hematopoietic stem cell transplant (HSCT) recipient What every transplanter needs to know. Bone Marrow Transplant 2004 33 137-152. 

Twenty percent of patients receiving pelvic irradiation may experience hemorrhagic cystitis, especially with concurrent cyclophosphamide. Viral infections commonly associated with this condition occur most frequently in bone marrow transplant recipients who also may receive cyclophosphamide. 

High-dose cyclophosphamide (bone marrow transplant)... 

AMI Acute myocardial infarction BMT Bone marrow transplantation... 

Hildebrandt GC, Duffner UA, Olkiewicz KM, et al. A critical role for CCR2/ MCP-1 interactions in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation. Blood 2004 103(6) 2417-2426. 

Recently, a lectin made from purified elderberry (Sambucus nigra) has been used in the fractionation of normal bone marrow cells. Fractionation minimizes the effects of radiation on normal tissue. This work has been carried out by Dr. Madeleine Mumcuoglu, who patented the elderberry flu formulas, as well as doctors Daphna Manor and Shimon Slavin. There is hope that elderberry contains properties that may have potential in improving the success of bone marrow transplants. 

Leukine Sargramostim (GM-CSF) Immunex Autologous bone marrow transplantation, neutropenia resulting from chemotherapy, peripheral blood progenitor cell mobilization, and transplantation... 

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