Anemias aplastic

Hematologic Hematopoietic complications, some fatal, include thrombocytopenia, leukopenia, granulocytopenia, agranulocytosis, and pancytopenia. Macrocytosis and megaloblastic anemia usually respond to folic acid therapy. Eosinophilia monocytosis leukocytosis simple anemia hemolytic anemia aplastic anemia ecchymosis. [Pg.1213]

Hematologic- Eosinophilia transient neutropenia leukocytosis leukopenia thrombocythemia thrombocytopenia agranulocytosis granulocytopenia hemolytic anemia bone marrow depression pancytopenia decreased platelet function anemia aplastic anemia hemorrhage. [Pg.1525]

Hematologic - Methotrexate can suppress hematopoiesis and cause anemia, aplastic anemia, pancytopenia, leukopenia, neutropenia, and/or thrombocytopenia. Use with caution, if at all, in patients with malignancy and preexisting hematopoietic impairment. [Pg.1974]

NSAIDs. Hematopoietic side effects (e.g., leukopenia, hemolytic anemia, aplastic anemia, purpura, thrombocytopenia, and agranulocytosis) also may occur. Ocular effects (blurred vision, corneal deposits) have been observed in patients receiving indomethacin, and regular ophthalmological examinations are necessary when the drug is used for long periods. Hepatitis, jaundice, pancreatitis, and hypersensitivity reactions also have been noted. [Pg.430]

Unlabeled Uses To decrease the risk of colon cancer Contraindications Anemias (aplastic, normocytic, pernicious, refractory)... [Pg.531]

Hematologic reactions (leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, aplastic anemia, pancytopenia)... [Pg.100]

Adverse Reactions Hypoglycemia Gastrointestinal disturbances (nausea, diarrhea, constipation, gastralgia) Dermatologic reactions (erythema, morbilliform or maculopapular eruptions, urticaria, pruritus, and eczema) Hematologic reactions (leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, aplastic anemia, pancytopenia) Metabolic reactions (hepatic porphyria, disulfiram-like reactions) Hyponatremia Elevated liver enzymes... [Pg.102]

Hematologic Anemia, aplastic anemia, neutropenia, thrombocytopenia, thrombotic thrombocytopenic purpura... [Pg.88]

Oral use of sulfonamides, pyrimethamine, and trimethoprim can canse blood dyscrasias such as hemolytic anemia, aplastic anemia, lenkopenia, and agran-nlocytosis. Becanse these blood changes are due to a drug-induced folic acid deficiency, administering folinic (not folic) acid can coimteract the toxicity. Use of folinic acid bypasses the need fc>r dihydrofolate reductase by supplying the fully reduced folate. [Pg.194]

Most hematological adverse effects associated with trimethoprim have been reported with co-trimoxazole. These include macrocytic and megaloblastic anemia, aplastic anemia, neutropenia, hypersegmentation of leukocytes, thrombocytopenia, and pancytopenia (12,61-63,75-79). Sulfonamides alone have not been associated with folate deficiency, but in combination with trimethoprim they can deplete folate stores in patients with preexisting deficiency of folate or vitamin B12 (80). Treatment with co-trimoxazole can impair the function of mobilized autologous peripheral blood stem cells (81). [Pg.3512]

Adverse effects sedation, ataxia, diplopia (seizures in OD), osteomalacia, hematotoxidty (gran-Tocytopenia, megaloblastic anemia, aplastic anemia), water retention (f ADH),and exfoliative... [Pg.149]

CNS depression Osteomalacia Megaloblastic anemia Aplastic anemia Exfoliative dermatitis... [Pg.142]

CHRONIC HEALTH RISKS asthma anemia aplastic anemia allergies exfoliative dermatitis eczema of the eyelids fatal liver damage. [Pg.830]

Hypoplastic i.e., aplastic anemia Aplastic Anemia caused by deficient red cell production due to bone-marrow disorders. [Pg.696]

Carbonie anhydrase inhibition Acidosis, metabolic Alopecia (hair loss) Anaphylaxis Anemia, aplastic Anxiety Bone marrow suppression Chronic fatigue syndrome Confusion Corneal edema Depression Dyspepsia Dysphagia Impotence Irritation Keratitis Malaise Nausea Nephrotoxic Neuroprotector, Paralysis Pulmonary edema Renal tubular acidosis Stevens-Johnson syndrome Taste disturbance Thromboeytopenia Urinary stone Vision blurring Weight loss... [Pg.344]

The answer is 3 [It C/. Plasma iron and erythropoietin levels are increased in aplastic anemia because the reduced bone marrow mass is unable to fully use these components in normal synthesis. Aplastic anemia usually is a result of r uced deoxyribonucleic acid (DNA)-controlled synthesis of pluripolent bone marrow precursors of erythrocytes, leukocytes, and thrombcxtytes. Fetal hemoglobin synthesis may increase in adults with aplastic anemia. Aplastic anemia is characterized by macrocytes and increased numbers of reticulocytes. [Pg.180]

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