Physostigmine sulfate

Parasympathomimetics such as physostigmine sulfate increase the level of acetylcholine, which contracts the ciliary muscle and opens the fluid pathway which leads to reduction in IOP. They are usually used with pilocarpine hydrochloride or pilocarpine nitrate, which acts on cholinoceptors. Parasympathomimetics cause poor night vision because of miosis. 

Sodium benzoate was shown by Asker and Harris (108) to be an effective photostabilizer for physostigmine sulfate solutions. The photostability of minoxidil solution is also enhanced by sodium benzoate (48). Figure 17 shows the absorption curves of sodium benzoate and minoxidil. As can be seen in the figure, sodium benzoate absorbs radiation in the same range as minoxidil, thus acting as a photoprotective agent for the drug (109). 

Uric acid in very low concentrations, very strongly absorbs UV radiation and for this reason, has been used to protect various FD C colors against fading when they will be probably exposed to direct sunlight (112). Uric acid has been found to enhance the photostability of solutions of colchicine (70) and FD C Blue No. 2 (82,113). Sodium urate, the neutral salt of uric acid, has a photoprotective effect on solutions of metronidazole (68), doxorubicin hydrochloride (77), and physostigmine sulfate (108). In addition to its photon-absorbing property, uric acid has been reported to also possess antioxidant quality (114). 

Sodium sulfite stabilizes solutions of daunorubicin hydrochloride (75) and physostigmine sulfate (108). Sodium sulfite, however, was reported by Asker and Canady (83) to be most detrimental to the photostability of sodium nitroprus-side solution. 

Asker, A.F. Harris, C.W. Influence of certain additives on the photostability of physostigmine sulfate solutions. Drug Dev. Ind. Pharm. 1988,14, 733-746. 

Physostigmine Sulfate, USP. Phy.sostigmine sulfat occurs as a while, odorless, microcryslalline powdertliali delique.scent in moist air. It is soluble in waier(l 4).alc(iM (1 0.4). and ether (1 1200). It has the advantage over tie salicylate salt of being compatible in sniulion with hcmulkii nium chloride and related compounds. 

Physostigmine sulfate and physostigmine salicylate (Antilirium) are cholinesterase inhibitors that are indicated as antidotes to poisoning from substances possessing anticholinergic properties such as imipramine, a tricyclic antidepressant. In addition, it has been used in open-angle glaucoma. 

Eserine sulfate Physostigmine sulfate C3OH44N0O8S 64-47-1 648.770 hyg cry 141 VS ace, EtOH... 

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