Detector selection

Other Detectors Two additional detectors are similar in design to a flame ionization detector. In the flame photometric detector optical emission from phosphorus and sulfur provides a detector selective for compounds containing these elements. The thermionic detector responds to compounds containing nitrogen or phosphorus. 

The choice of a detector for a specific appHcation should be made in order to minimize the cooling requirements and the magnitude of the background radiation noise therefore, in detector selection the cutoff wavelength should be only slightly greater than that required by the appHcation. If the... 

Detectors. The function of the gc detector is to sense the presence of a constituent of the sample at the outlet of the column. Selectivity is the property that allows the detector to discriminate between constituents. Thus a detector selective to a particular compound type responds especially weU to compounds of that type, but not to other chemical species. The response is the signal strength generated by a given quantity of material. Sensitivity is a measure of the abiHty of the detector to register the presence of the component of interest. It is usually given as the quantity of material that can be detected having a response at twice the noise level of the detector. 

Here the sum runs over all possible initial states and the operator describes the interaction of the electrons and the radiation field with wave vector q and polarization A. In Eq. (1) it has been assumed that the detector selectively counts photo electrons with energy E, wave vector k, and spin polarization The corresponding final... 

In the single wavelength detector, 254 nm and 280 nm are strong lines from the mercury source and hence, are selected in most comnercial instruments. Of the three types of U.V. detectors, this one gives the lowest noise level (down to 0.00002 O.D.), but, of course, some flexibility is lost in not being able to work at other wavelengths. Nevertheless, when one purchases an instrument, this is the first detector selected. 

Ability to analyze unreacted monomers was dependent on detector selectivity. The UV detector was operated at 254 nm for analysis of AN/S latex solutions. Styrene is a strong UV abosrber at this wavelength while acrylonitrile has no measurable absorbance at 254 nm. Thus, the UV detector was entirely selective to monomeric styrene. The refractometer detector was sensitive to both acrylonitrile and styrene when each was present in the desired copolymer proportions (70/30). However,... 

Detector selectivity is much more important in LC than in GC since, in general, separations must be performed with a much smaller number of theoretical plates, and for complex mixtures both column separation and detector discrimination may be equally significant in obtaining an acceptable result. Sensitivity is important for trace analysis and for compatibility with the small sizes and miniaturised detector volumes associated with microcolumns in LC. The introduction of small bore packed columns in HPLC with reduced peak volume places an even greater strain on LC detector design. It is generally desirable to have a nondestructive detector this allows coupling several detectors in series (dual... 

While most preliminary SFC-plasma coupled techniques employed microwave-induced plasmas (MIPs), the use of ICP-MS is now increasing [469]. An advantage of microcolumn SFC-ICP hyphenation is the significantly reduced flow-rates of microcolumns compared with those of conventional columns. Both pSFC-ICP-AES [470,471] and cSFC-ICP-AES [472] were described. In the case of elemental detector selectivity (e.g. AES) complete chromatographic resolution is not required. The detector possesses linearity over several orders of concentrative magnitude. Minimum detectable quantities for nonmetals range from sub to low ng mL"1. 

Nagels, L.J., Creten, W.L. (1985). Evaluation of the glassy carbon electrochemical detector selectivity in high-performance liquid chromatographic analysis of plant material. Anal. Chem. 57, 2706. 

The current individual methods differ in procedure, compounds detected, extraction techniques, and extraction solvents used. Some methods may include a cleanup step to remove biogenic (bacterial or vegetation-derived) material, while others do not. The methods have in common a boiling point type of column and a flame ionization detector. Selection of a method depends on the type of hydrocarbon suspected to be in the sample. 

Module 3, Column and Mobile Phase Design (CMP). This is the core module for ECAT. It can currently specify i) analytical column and mobile phase constituents for reverse phase chromatography of common classes of organic molecules ii) reverse phase, ion exchange phase and hydrophobic interaction chromatography of proteins and peptides iii) a limited set of specialty classes of molecules best treated by straight phase chromatography (e.g., mono- and disaccharides). The rules for selection of the HPLC detector are under development within Module 3. Some of the rules for detector mobile phase compatibility are already encoded. A set of rules for detector selection is ready but not yet encoded. 

Incrementing Module 3 (CMP) according to sample probe testing by chromatographers not directly associated with the project and adding detector selection rules. 

Expansion of the data bases in Module 1 to include spectroscopic and electrochemical data to be used by the detector selection rules of Module 3. (This would include UV absorbance spectral properties of organic molecules, fluorescence quenching and activating properties of solvent environments, and electro-... 

Eortunately, for most photon device photodetectors, the dependence on modulation frequency is fairly flat across most of the region likely to be encountered with conventional NIR analyzer technology. Provided the D is satisfactory at the required measurement wavelengths, it is one useful parameter for detector selection. 

Source and detector selection are interrelated, where the output of the source is matched to the sensitivity range of the detector. However, the exact nature of the source is also dependent on the type of sample(s) under consideration, the intended optical geometry, the type of measurement technique, and the final desired performance. The bottom line is that adequate source energy must reach the detector to provide a signal-to-noise performance consistent with the required precision and reproducibility of the measurement. This assumes that the detector is well matched, optically and performance-wise, and is also capable of providing the desired performance. 

The second stage is data acquisition. This stage is entered when the operator starts the instrument. The instrument makes the first injection and signals the microcomputer via Intelink. After a delay proportional to the void volume of the column set, data are collected on a time basis (constant flow rate assumed) at the predetermined rate from each of the detectors selected, up to a maximum of three simultaneous detectors. VHien the sample run is complete, the instrument again signals the microcomputer which places the instrument in a hold state while it reads the operational parameters from the instrument for that sample and... 

An example of operator interaction with the primary analysis program, GPC, is shown in Figure 5. The job number assigned by the computer during sample definition is entered along with the detector selected for analysis. The operator then selects the baseline and the limits for data analysis by entering the times of the desired points. The plots desired and the disposition of the report file are chosen. The most recent calibration curve on file for the column set is used by default but others may be selected at the operator s option. 

Figure 14.1 Schematic view of a mass spectrometer. Its basic parts are ion source, mass analyzer, and detector. Selected principles realized in modern mass spectrometers are assigned El—electron impact. Cl—chemical ionization, FAB—fast atom bombardment, ESI—electrospray ionization, MALDI—matrix-assisted laser desorption/ionization. Different combinations of ion formation with mass separation can be realized.

Detector selection was relatively straightforward. Because the electron capture detector (ECD) offered sensitivities for HCCP and HCBD that could not be equaled by any other GC detection system, the ECD was employed for the determination of these two... 

Selective ion receptors represent basic units for ionic transmitters or detectors selective ion carriers correspond to ionic transducers. These units may be fitted with triggers and switches sensitive to external physical (light, electricity, heat, pressure) or chemical (other binding species, regulating sites) stimuli for connection and activation. 

Needs for improved measurement methods differ depending on whether one is considering low or high transmission rate materials. In the former case one needs very sensitive detectors. Selectivity is also desirable so that interferences from extraneous species can be avoided. In the case of high transmission rate materials instrumental time constants and saturation effects need to be better understood. In all cases there is a need for more convenient instruments and a better knowledge of their operating principles. 

Photoionization detector selective to aromatic and unsaturated compounds... 

Fluorometer—a detector selective to compounds with fluorescent emission spectra... 

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