Carcinogenesis possible mechanism

Miller, E.C. and Miller, J.A., "The Metabolism of Chemical Carcinogens to Reactive Electrophiles and Their Possible Mechanisms of Action in Carcinogenesis", Am. Cliem. Soc. Monograph, 1976, 173, 737-762. 

Miller EC, Miller JA. The metabolism of chemical carcinogens to reactive electrophiles and their possible mechanism of action in carcinogenesis. In Searle CE, ed. Chemical Carcinogens. Washington D.C. American Chemical Society, 1976. A seminal article by the original authors of this important concept. 

Wang, M.Y. Liehr, J.G (1995) Lipid hydroperoxide-induced endogenous DNA adducts in hamsters possible mechanism of lipid hydroperoxide-mediated carcinogenesis. Arch. Biochem. Biophys., 316, 38-46... 

Many questions in the investigation of a possible mechanism for antioxidant inhibition of mammary carcinogenesis have led us to the need to be able to measure actual tissue concentrations of these compounds. Since BHT was found to be a very effective mammary tumor inhibitor in this model, and BHA to have no measurable effect under the same experimental conditions, one has to ask the question as to whether or not both are absorbed and taken up by the tissues, specifically mammary tissue, since this is the target tissue. BHT was not effective as an inhibitor when fed for three weeks from weaning, then stopped one week prior to carcinogen treatment (35). 

Despite these difficulties, several possible mechanisms of metal carcinogenicity have been proposed. Genotoxic mechanisms of metal carcinogenesis include direct DNA damage ... 

Gabrielson EW, Van der Meeren A, Reddel RR, et al. 1992. Human mesothelioma cells and asbestos-exposed mesothelial cells are selectively resistant to amosite toxicity A possible mechanism for tumor promotion by asbestos. Carcinogenesis 13 1359-1363. 

It is believed that UVR exposure causes skin immune suppression. Both UVB and UVA have been implicated (292). A possible mechanism is UVA-induced lipid peroxidation, which results in the migration of immune-mediating cells from the epidermis and therefore leads to skin immune suppression (224). It has been suggested that skin immune suppression plays a role in carcinogenesis. However, the relationship between the two is not well understood yet (293). 

Ghoshal, A., Davis, C.D., Schut, H.A.J., and Snyderwine, E.G. (1995) Possible mechanisms for PhIP-DNA adduct formation in the mammary gland of female Sprague-Dawley rats. Carcinogenesis, 16, 2725-2731. 

Lin, D.-X., Meyer, D.J., Ketterer, B., Lang, N.P., and Kadlubar, F.F. (1994) Effects of human and rat glutathione-S-transferase on the covalent binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro a possible mechanism of organ specificity in their carcinogenesis. Cancer Res., 54, 4920-4926. 

Yang, G. Y., Liao, J., Li, C., Chung, J., Yurkow, E. J., Ho, C. T., and Yang, C. S. 2000. Effect of black and green tea polyphenols on c-jun phosphorylation and H(2)0(2) production in transformed and non-transformed human bronchial cell lines Possible mechanisms of cell growth inhibition and apoptosis induction. Carcinogenesis 1 2035-39. 

Possible Mechanism of Protective Effect of Dietary Fiber In Colon Carcinogenesis... 

A possible explanation for why Ni3S2 is a potent carcinogen while amorphous NIS lacks activity was presented in the uptake studies. From other experiments it appears that the carcinogenic activity of particulate metal compounds is proportional to their cellular uptake. In future studies we hope to concentrate on this phagocytosis as a possible mechanism of metal induced carcinogenesis. 

Reddy BS. Possible mechanisms by which pro- and prebiotics influence colon carcinogenesis and tumor growth. / Nutr. 1999 129 1478S—1482S. Rafter J, Bennett M, Caderni G, et al. Dietary sjmbiotics reduce cancer risk factors in polypectomized and colon cancer patients. Am J Clin Nutr. 2007 85 488-496. 

The diet is believed to play an important role in the onset of carcinogenesis, and there are a number of carcinogens present in food, including mycotoxins, polycyclic hydrocarbons, and pesticides. Associations have been made between dietary fat intake and morbidity and mortality from breast and colon cancer. Another possible mechanism for the proposed protective effects against cancer of olive oil compared with sunflower oil involves diet-induced alterations in host immune responses. Both the type and concentration of dietary fats have been reported to influence immune status in several animal models. The PUFA Cigtz is necessary for T-cell-mediated immunity, but high intakes will suppress immune function and may therefore increase the risk of cancer. Furthermore, comparisons between the effects of diets rich in Ci8 2 and those rich in Cig i on varying indicators of immune function in mice have shown that, while dietary Ci8 2 predisposed... 

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