Carcinogenesis, mammary

Nandi, S. Guzman, R. C. Yang, J. Hormones and mammary carcinogenesis in mice, rats, and humans a unifying hypothesis. Proc. Natl. Acad. Sci. USA 1995, 92, 3650-3657. 

The consumption of a mixture of phenolic compounds presented in apple or purple grape juice inhibited mammary carcinogenesis in 7,12-dimethylbenzo[a]anthracene (DMBA) treated rats (Liu and others 2005 Jung and others 2006). However, the individual antioxidants of these foods studied in clinical trials, including (3-carotene, vitamin C, and vitamin E, do not appear to have consistent preventive effects comparable to the observed health benefits of diets rich in fruits and vegetables, suggesting that natural phytochemicals in fresh fruits and vegetables could be more effective than a dietary supplement. 

Amagase J and Milner JA. 1993. Impact of various sources of garlic and their constituents on 7,12-dinielliyllxMizI(v anthracene binding to mammary cell DNA. Carcinogenesis 14 1627—1631. 

Garcia-Solis P, Yahia EM and Aceves C. 2008. Study of the effect of Ataulfo mango (Mangifera indica L) intake on mammary carcinogenesis and antioxidant capacity in plasma of /V-methyl-nitrosourea (MNU)-treated rats. Food Chem 111 309—315. 

Anzano MA, Peer CW, Smith JM, Mullen LT, Shrader MW, Logsdon DL, et al. (1996) Chemoprevention of mammary carcinogenesis in the rat combined use of raloxifene and 9-cis-retinoic acid. J Natl Cancer Inst 88 23-25... 

Hilakivi-Clarke, L., Onojafe, L, Raygada, M., Cho, E., Skaar, T., Russo, I. and Clarke, R. (1999). Prepubertal exposure to zearalenone or genistein reduces mammary carcinogenesis, Br. J. Cancer., 80, 1682-1688. 

Murrill, W.B., Brown, N.M., Zhang, J.X., Manzolillo, P.A., Barnes, S.A. and Lamartiniere, C.A. (1996). Prepubertal genistein exposure suppresses mammary cancer and enhances gland differentiation in rats. Carcinogenesis, 17,1451-1457. 

Constantinou AI, Mehta R, Husband A. (2003) Phenoxodiol, a novel isoflavone derivative, inhibits dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female Sprague-Dawley rats. Fur J Cancer 39 1012-1018. 

In a study of carcinogenesis, DBCP was orally administered to rats and mice 5 times/week at maximally tolerated doses and at half those doses. ° As early as 10 weeks after initiation of treatment, there was a high incidence of squamous cell carcinomas of the stomach in both species. In female rats there were also mammary adenocarcinomas. Chronic inhalation resulted in carcinomas of the respiratory tract in mice and multiple site tumors in rats. ... 

Relationship between amount and type of dietary fat in promotion of mammary carcinogenesis induced by 7,12-dimethylbenz[a] anthracene. J Natl Cancer Inst 1979 62(4) 1009-1012. 

Fritz, W, Wang, J, Coward L, Lamartiniere CA. Dietary genistein perinatal mammary cancer prevention, bioavailability and toxicity testing in the rat. Carcinogenesis 19, 2151-2158, 1998. 

Cotroneo MS, Wang J, Fritz WA, Eltoum IE, Lamartiniere CA. Genistein action in the prepubertal mammary gland in a chemoprevention model. Carcinogenesis 23, 1467-1474, 2002. 

Medina, V., Croci, M., Crescenti, E., Mohamad, N., Sanchez-Jimenez, F., Massari, N., Nunez, M., Cricco, G., Martin, G., Bergoc, R., and Rivera, E. (2008). The role of histamine in human mammary carcinogenesis H3 and H4 receptors as potential therapeutic targets for breast cancer treatment. Cancer Biol. Ther. 7(1), 28-35. 

CLA, the acronym for a series of conjugated dienoic isomers of linoleic acid, occurs naturally in many foods, particularly dairy products and other foods derived from ruminant animals (6). Synthetically prepared CLA inhibits chemically-induced mouse epidermal and forestomach neoplasia (7,8) and rat mammary neoplasia (9). Hence, the effect of CLA on carcinogenesis is opposite that of linoleic acid. 

Richards, J., Guzman, R., Yang, J., Nandi, S., and Konrad, M. (1980). Chemical carcinogenesis of mammary epithelium in cell culture, page 467 in Cell Biology of Breast Cancer, McGrath, C.M., Brennan, M.J., and Rich, M.A., Eds. (Academic Press, New York). 

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