Bronchial cells

Nickel water-soluble salts were also reported to induce chromosome aberrations in CHO cells [444, 445] and in mouse mammary carcinoma cells [260, 446], Changes in growth control and chromosome aberrations in human bronchial cells were demonstrated in vitro after exposure to nickel sulphate the changes were insufficient to cause the cells to be tumourigenic [447], Nickel chloride was unable to produce chromosome aberrations in vivo in mammalian male germ cells [448],... 

N. V. Chemuturi, P. Hayden, M. Klausner, and M. D. Donovan. Comparison of human tracheal/bronchial cell culture and bovine nasal respiratory explants for nasal drug transport studies. J Pharm Sci 94 1976-1985 (2005). 

Endothelin 1 (ETl) is a 21-amino acid peptide released from bronchial cells. It has potent vasoconstrictive agonist properties mediated by two receptor types (A and B). The involvement of the endothelin 1 type A (EDNRA) gene (Afill SNP) in atopy, however, is marginal at best and as yet not widely replicated (181). For... 

There is conflicting evidence concerning the mutagenicity of 1,2-dimethylhydrazine to bacteria. In a single study, it induced recombination in Saccharomyces cerevisiae. In vitro, 1,2-dimcthylhydrazine formed DNA adducts in human bronchial cells, provoked unscheduled DNA synthesis in rat hepatocytes and induced gene mutation in mammalian cells. It gave positive results in rodents in microbial host-mediated assays. 

DNA damage 1988 Human bronchial cells (culture) ND + Grafstrom et al. ... 

Human bronchial cells DMA strand breakage No data - Lechner et al. 1983 CR, CH, AM... 

Offord, E.A., Mace, K., Ruffieux, C., Malnoe, A. and Pfeifer, A.M. 1995. Rosemary components inhibit benzo(a)pyrene-induced genotoxicity in human bronchial cells. Carcinogenesis. 16 2057-2062. 

The 16HBE14o- and BEAS-2B cells are viral transformed bronchial cell lines.52,57 P-gp is expressed in 16HBE14o- cells, tight junctions form, and transport experiments can be carried out in 8 to 10 days, but the cells lack a representative mucus layer. Apical microvilli and cilia can be produced when 16HBE14o- cells are grown at an air interface, but this may not be favorable due to the basal origin of the cells.51,57 The use of BEAS-2B cells for transport studies is limited by their low TEER.57... 

Grafstrom RC, Fomace AJ, Autrup H, et al. 1983. Formaldehyde damage to DNA and inhibition of DNA repair in human bronchial cells. Science 220 216-218. 

A gastropulmonary reflex Irritation of the upper gastrointestinal tract produces emesis afferent impulses go to the emetic centre in visceral sensible nerves in the gastric mucosa. Emesis starts with saliva secretion and indisposition. The dose of the reflex expectorants is so chosen so that the first stage is reached secretion of less viscous fluid in the bronchial cells. 

Yang, G. Y., Liao, J., Li, C., Chung, J., Yurkow, E. J., Ho, C. T., and Yang, C. S. 2000. Effect of black and green tea polyphenols on c-jun phosphorylation and H(2)0(2) production in transformed and non-transformed human bronchial cell lines Possible mechanisms of cell growth inhibition and apoptosis induction. Carcinogenesis 1 2035-39. 

The degree fo which radon daughfers attach fo aerosol particles is an important factor in determining the radiation dose to which bronchial cells are exposed. The unattached fraction (f) remain charged and are deposited in the airways more efficiently than the fraction attached to aerosol dusts. They therefore produce a higher resulfanf radiation dose to sensitive tissue. The particle size distribution of fhe aerosol-attached activity will also have a major effect on the airway deposition pattern and hence the radiation dose received in various regions of the respiratory system. 

A third mechanism for treating inflammation involves antagonizing the effects of chemicals released by immune cells. Histamine, released by mast cells and basophils in response to antigens, causes bronchial constriction and inflammation by binding to histamine receptors on bronchial cells. Antihistamines are antagonists which compete with histamine for these receptors. 

P. G. Antonucci, B. H. Bryant, and J. P. Wise, Sr. 2004. Telomerase-mediated hfespan extension of human bronchial cells does not affect hexavalent chromium- induced cytotoxicity or genotoxicity. Mol. Cell. Biochem. 255(1-2) 103-11. 

Two extracts of E. purpurea were capable of in vitro reversing the release of more than 30 cytokine-related mediators of inflammation in human bronchial cells infected with rhino vims 14. The fact that the same extracts stimulated cytokine production in uninfected cells further substantiated the reputed immunostimulant effects of Echinacea. ... 

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