Cell growth, inhibition

TABLE 5.1 IC50 (nM) Values from Cell-Growth Inhibition Assays... 

Zaharevitz DW, Holbeck SL, Bowerman C, Svetlik PA. COMPARE a web accessible tool for investigating mechanisms of cell growth inhibition. J. Mol. Graph. Model. 2002 Jan 20(4) 297-303. 

S. W. Lee, C. L. Reimer, P. Oh, D. B. Campbell, and J. E. Schnitzer. Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells. Oncogene 16 1391-1397 (1998). 

Suzuki, T., Nagano, Y, Kouketsu, A., Matsuura, A., Maruyama, S., Kurotaki, M. et al. (2005) Novel Inhibitors of human histone deacetylases design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. Journal of Medicinal Chemistry, 48, 1019—1032. 

Table 1 Cell growth inhibition by lapatinib, gefitinib, and erlotinib [69] ...

Du W, Lebowitz PF, Prendergast GC. Cell growth inhibition by famesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB. Mol Cell Biol 1999 19 1831-1840. 

Table 2. Cell growth inhibition caused by different concentration of extractable fluoride according to Gervits [19]...

In order to separate effects of cell growth inhibition not induced by toxic potential, an extra microscopic evaluation of the test cells must be performed in each case. 

Arisawa, M. Cell growth inhibition of KB cells by plant extracts. Nat Med... 

Peloi, L. S., Soares, R. R. S., Biondo, C. E. G., Souza, V. R., Hioka, N., and Kimura, E. (2008). Photodjmamic effect of light-emitting diode on cell growth inhibition induced by methylene blue. /. Biosci. 33(2), 231-237. 

Zi X, Agarwal R. Silibinin decreases prostate-specific antigen with cell growth inhibition via G1 arrest, leading to differentiation of prostate carcinoma cells implications for prostate cancer intervention. Proc Natl Acad Sci USA 1999 96 7490-7495. 

Several effects of forskolin on B-lymphocytes, the cells of the immune system responsible for the production of immunoglobulins, have further been reported. This diterpene was found to inhibit cellular proliferation of B cells stimulated either by antibodies to surface immunoglobulins (anti-mu), and an antibody to CD20 antigen or 12-O-tetradecanoyl phorbol 13-acetate [219]. There was also a clear inhibition of G1 entry and DNA synthesis, and forskolin maintained its inhibitory effect even when added later after anti-mu stimulation. Additionally, no differences were found in the inhibitory effect of forskolin on neoplastic B cells, as compared to the responses of normal cells. Growth inhibition associated with an accumulation of cells in G1 was later found when cells of the B-lymphoid precursor cell line Reh were incubated with forskolin [220]. In that study, a delay of cells in G2/M prior to G1 arrest was observed, suggesting that important restriction points located in the G1 and G2 phases of the cell cycle may be controlled by forskolin (due to cAMP levels elevation). In a subsequent study [221], it was found that the arrest of Reh cells was accompanied by rapid dephosphorylation of retinoblastoma protein, which was suggested to be a prerequisite for the forskolin mediated arrest of these cells in Gl. 

The cell growth inhibition data confirmed that, of the optically active (3-lactam, 66 and 58 were extremely active (obtained from two different pathways), and the activity of the other optical isomer 68 and 59 (obtained from two different pathways) was reduced compared to the racemic (3-lactam 1. 

It has been shown that EGCG-induced apoptosis, cell-growth inhibition, and cell-cycle dysregulation in human prostate cancer DU145 and LNCaP cells without producing similar effects in normal cells [Ahmad et al., 1997 ... 

Periyasamy S, Sanchez ER. 2002. Antagonism of glucocorticoid receptor transactivity and cell growth inhibition by transforming growth factor-beta through AP-1-mediated transcriptional repression. Int J Biochem Cell Biol 34 1571-1585. 

The northeast Pacific bryozoans Phidolopora pacifica contained two nitrophenols, desmethylphidolopin (448) and 3-nitro-4-hydroxybenzyl alcohol (449) (365). Desmethylphidolopin (448) showed antimicrobial activity. 2-Amino-6-[(r/ ,2 5)-l, 2 -dihydroxypropyl]-3-methyl pterin-4-one (450) was isolated from the anthozoan Astroides calycularis collected in the Bay of Naples and exhibited cell growth-inhibiting activity (366). The structure of leucettidine, a pteridine derivative found in Leucetta microra-... 

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