Induced lipid peroxidation

Kunimoto, M., Inoue, E., and Nojima, S. (1981). Effect of ferrous ion and ascorbated induced lipid peroxidation on liposomal membranes, Biochim. Biophys. Acta, 646, 169-178. 

Lodge, J.K., Patel, S.U. and Sadler, P.J. (1993). Aldehydes from metal ion- and lipoxygenase-induced lipid peroxidation detection by H-n.m.r. spectroscopy. Biochem. J. 289, 149-153. 

Kramer, J.H., Mak, I.T. and Weglicki, W.B. (1984). Differential sensitivity of canine cardiac sarcolemmal and microsomal enzymes to inhibition by free radical-induced lipid peroxidation. Circ. Res. 55, 120-124. 

In studies in Alzheimer s brain, in vitro induction of lipid peroxidation by iron is more intense than in control cortical samples (Andorn et al., 1990 Subbarao et nL, 1990 McIntosh et al., 1991). The 21-aminosteroid U-74500A has been shown to effectively inhibit iron-induced lipid peroxidation in Alzheimer s brain samples (Subbarao et al., 1990). 

Copper salts such as CuS04 are potent catalysts of the oxidative modification of LDL in vitro (Esterbauer et al., 1990), although more than 95% of the copper in human serum is bound to caeruloplasmin. Cp is an acute-phase protein and a potent inhibitor of lipid peroxidation, but is susceptible to both proteolytic and oxidative attack with the consequent release of catalytic copper ions capable of inducing lipid peroxidation (Winyard and... 

Moysan, A., Marquis, I., Gaboriau, F., Santus, R., Dubertret, L. and Morliere, P. (1993). Ultraviolet A-induced lipid peroxidation and antioxidant defence systems in cultured skin fibroblasts. J. Invest. Dermatol. 100, 692-698. 

Punnonen, K., Puntala, A., Jansen, C.T. and Ahotupa, M. (1991a). UVB irradiation induces lipid peroxidation and reduces antioxidant enzyme activities in human keratinocytes in vitro. Acta Dermato-Venereol. 71,... 

Treatment with iron chelators and a-tocopherol protect against lipid p>eroxidation and hepatocellular injury in iron-overloaded rats (Sharma etal., 1990). When hepatocytes are isolated from rats, which have been pretreated with a-tocopherol, there is a significant reduction in iron-induced lipid peroxidation and improvement in cell viability in vitro (Poli et al., 1985). Similar effects were seen when hepatocytes were incubated with iron chelators (Bacon and Britton, 1990). Treatment of moderately, but not heavily, iron-loaded rats with desferrioxamine in vivo inhibits the pro-oxidant activity of hepatic ultrafiltrates (Britton et al., 1990b). 

Fairhurst, S., Barber, D.J., Clark, B. and Horton, A.A. (1982). Studies on paracetamol-induced lipid peroxidation. Toxicology 23, 249-259. 

Kato, S., Kawase, T., Alderman, J., Inatomi, N. and Lieber, C.S. (1990). Role of xanthine oxidase in ethanol-induced lipid peroxidation in rat. Gastroenterolc 98, 203-210. 

Shaw, S., Jayatilleke, E., Ross, W.A., Gordon, E.R. and Lieber, C.S. (1981). Ethanol-induced lipid peroxidation, potentiation by long-term alcohol feeding and attenuation by methionine. J. Lab. Clin. Med. 98, 417-424. 

Younes, M. and Wess, A. (1990). The role of iron in t-butyl hydroperoxide-induced lipid peroxidation and hepatotoxicity in rats. J. Appl. Toxicol. 10, 313-317. 

The phenothiazines, chlorpromazine and promethazine, have been described as inhibitors of CCU-induced lipid peroxidation at relatively high concentrations in rat liver microsomes (Slater, 1968). Structural modifications of chlorpromazine were undertaken to try to increase antioxidant activity and maintain molecular lipophilicity. The 2-N-N-dimethyl ethanamine methanesulphonate-substituted phenothiazine (3) was found to be a potent inhibitor of iron-dependent lipid peroxidation. It was also found to block Cu -catalysed oxidation of LDL more effectively than probucol and to protect primary cultures of rat hippocampal neurons against hydrogen peroxide-induced toxicity in vitro (Yu et al., 1992). 

Another pyrimidine derivative, RA-642, has been found to inhibit ferrous-induced lipid peroxidation in cell... 

Bellido, L, de la Cruz, J.P. and de la Cuesta, S. (1991). The pyrimido pyrimidine derivative RA642 a potent inhibitor of ferrous induced lipid peroxidation. Meth. Find. Exp. Clin. Pharmacol. 13, 371-375. 

Lavelli V, Peri C and Rizzolo A. 2000. Antioxidant activity of tomato products as studied by model reactions using xanthine oxidase, myeloperoxidase, and copper-induced lipid peroxidation. J Agric Food Chem 48(5) 1442—1448. 

Oboh G, Puntel RL and Rocha JBT. 2007. Hot pepper (Capsicum annuum, Tepin and Capsicum Chinese, Habanero) prevents Fe2+-induced lipid peroxidation in brain—in vitro. Food Chem 102(1) 178—185. 

As a rule, oxygen radical overproduction in mitochondria is accompanied by peroxidation of mitochondrial lipids, glutathione depletion, and an increase in other parameters of oxidative stress. Thus, the enhancement of superoxide production in bovine heart submitochondrial particles by antimycin resulted in a decrease in the activity of cytochrome c oxidase through the peroxidation of cardiolipin [45]. Iron overload also induced lipid peroxidation and a decrease in mitochondrial membrane potential in rat liver mitochondria [46]. Sensi et al. [47] demonstrated that zinc influx induced mitochondrial superoxide production in postsynaptic neurons. 

Al-Bayati, Z.A.F., W.J. Murray, and S.J. Stohs. 1987. 2,3,7,8-,l etrachlorodibenzo-/)-dioxin-induced lipid peroxidation in hepatic and extrahepatic tissues of male and female rats. Arch. Environ. Contam. Toxicol. 16 159-166. 

Numan IT, Hassan MQ, Stohs SJ. 1990b. Protective effects of antioxidants against endrin-induced lipid peroxidation, glutathione depletion, and lethality in rats. Arch Environ Contam Toxicol 19 302-306. 

Ardelt BK, Borowitz JL, Maduh EU, et al. 1994. Cyanide-induced lipid peroxidation in different organs subcellular distribution and hydroperoxide generation in neuronal cells. Toxicology 89(2)... 

Yang XL, Huang C, Qiao XG, Yao L, Zhao DX, Tan X (2007e) Photo-induced lipid peroxidation of erythrocyte membranes by a bis-methanophosphonate fullerene. Toxicol. In Vitro 21 1493-1498. 

Figure 2. NO inhibits iron-induced lipid peroxidation. The rate of Oj consumption of HL-60 cells (5 X 10 /ml) was detennined using a YSI O2 monitor. Fe (20 pM) was added at the first arrow and subsequently NO (0.45 pM) was added (other arrows). When NO was added, the O2 consumption was inhibited for a period of a few min, then it resumed at near its initial rate until the reintroduction of additional NO. Also shown (lower dashed line) is a control of HL-60 cells subjected to Fe -induced oxidative stress in the absence of NO addition. The background rate of O2 uptake of the HL-60 cell suspension before the addition of Fe was 10 nM/sec. Upon the addition of 20 pM Fe, this rate increased to 220 nM/sec. The addition of NO resulted in a decrease in O2 consumption to <10 nM/sec. (From Kelley, E.E., Wagner, B.A., Buettner, G.R., and Bums, C.P., 1999, Arch. Biochem. Biophys. 370 97-104).

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