Against cancer

NB There is also conclusive evidence that these agents have a protective effect against cancers of the ovary and endometrium) Oral contraceptives, sequential (Suppl. 7 1987)... 

TALALAY p, FAHEY J w, HOLTZCLAW w D, PRESTERA T and ZHANG Y (1995) Chemoprotection against cancer by phase 2 enzyme induction , Toxicol Lett, 82-3, 173-9. 

TALALAY p (1991) Chemical Protection Against Cancer by Inducation of Electrophile Detoxification (phase 2) Enzymes Cellular Molec Targets Chemoprev, 1-11. 

TALALAY p and FAHEY j w (2001) Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism , JNutr, 131 3027S-33S. 

OGUNI I, CHEN s J, LIN p z and KARA Y (1992) Protection against cancer risk by Japanese green tea , Prev Med, 21, 332-3. 

Doll, R. Payne, P. Waterhouse, J., Eds. "Cancer Incidence in Five Continents" International Union Against Cancer Springer Verlag, Berlin, 1966. 

The most convincing data have been obtained from rodent models of cancers that revealed protective effects of curcumin against cancers of aU sites. Curcumin is able to inhibit all steps of cancer processes, initiation, progression, and promotion. These observations, combined with the apparent lack of toxicity of curcumin for doses up to 8 g/day for 3 mo suggest potential uses of curcumin as an anti-carcinogenic chemoprotective agent. ... 

Astaxanthin is a powerful bioactive antioxidant and has demonstrated efficacy in animal and human models of macular degeneration, a cause of blindness in a large population. It is also helpful in treating Alzheimer s and Parkinson s diseases and is known to offer protection against cancer. 

Figure 20. Selective cell targeting via specific monoclonal antibodies and/or antibody fragments directed against cancer cells and linked to the free amino groups of L-cysteine-coated metallic-core magnetic nanoparticles (MNP) (MNP = Co, Fe/Co, size 8-10 nm).

Cytotoxicity of Natural Triterpene QMs Against Cancer Cell Lines... 

American Joint Committee-International Union Against Cancer. 

Cisplatin is a platinum complex (platinum dichloride and two ammonia molecules) used as a cytostatic agent against cancer. The molecule cross-links DNA strands, thus leading to cell death. 

The effects of the bifunctional Pt drugs are very like those of the cross-linking dialkylating agents known to be effective against cancer (90). The reader is reminded of the parallel chemistry of carbonium ions and of platinum complexes, section IIF. 

Talalay, P. 2000. Chemoprotection against cancer by induction of phase 2 enzymes. Biofactors 12(1—4) 5—11. 

Carcinogenicity is one of the toxicological endpoints that pose the highest concern for human health. Nowadays, protection against cancer resulting from exposure to chemicals in the environment is a critical goal in public health management. 

Not all analogues become active against cancer cells through incorporation into nucleic acid. Some analogues block the synthesis of normal purine and pyrimidine nucleotides for example, 8-azaguanine blocks guanosine monophosphate (GMP) synthesis and 6-mercaptopurine inhibits adenosine monophosphate (AMP) syn-thesis. 

Among the most active alkylating agents used against cancer are nitrosoureas and aziridines. 

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