Colon carcinogenesis

Blum, C.A. et al., F romotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll Modnlation of apoptosis, cell proliferation, and 3-catenin/Tcf signaling, Mutat. Res., 523, 217, 2003. 

De Vogel, J. et al.. Green vegetables, red meat and colon cancer Chlorophyll prevents the cytotoxic and hyperproliferative effects of haem in rat colon. Carcinogenesis, 26, 387, 2005. 

Nelson R.L. Chlorophyllin, an antimutagen, acts as a tumor promoter in the rat dimethylhydrazine colon carcinogenesis model. Anticancer Res., 12, 737, 1992. 

Tanaka, T. et al., Suppression of azoxymethane-induced rat colon carcinogenesis by dietary administration of naturally occurring xanthophylls astaxanthin and canthaxanthin during the post-initiation phase, Carcinogenesis, 16, 2957, 1995. 

Roy, H.K., Olusola, B.F., Clemens, D.L. et al. 2002. AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis. Carcinogenesis 23 201-305. 

Davis P and Iwahashi CK. 2001. Whole almonds and almond fractions reduce aberrant crypt foci in a rat model of colon carcinogenesis. Cancer Letters 165 27-33. 

C. L. Crowley-Weber, K. Dvorakova, C. Crowley, H. Bernstein, C. Bernstein, H. Garewal and C. M. Payne, Nicotine increases oxidative stress, activates NF-kappaB and GRP78, induces apoptosis and sensitizes cells to genotoxic/xenobiotic stresses by a multiple stress inducer, deoxy-cholate relevance to colon carcinogenesis, Chem. Biol. Interact., 2003, 145(1), 53. 

H. Narahara, M. Tatsuta, H. lishi, M. Baba, N. Uedo, N. Sakai, H. Yano and S. Ishiguro, K-ras point mutation is associated with enhancement by deoxycholic acid of colon carcinogenesis induced by azoxymethane, but not with its attenuation by all-trans-retinoic acid, Int. J. Cancer, 2000, 88(2), 157. 

T. Narisawa, N. E. Magadia, J. H. Weisburger and E. L. Wynder, Promoting effect of bile acids on colon carcinogenesis after intra-rectal instillation of N-methyl-N -nitro-N-nitrosoguanidine in rats, J. Natl. Cancer Inst., 1974, 53(4), 1093. 

P. K. Baijal, E. P. Clow, D. W. Fitzpatrick and R. P. Bird, Tumourenhancing effects of cholic acid are exerted on the early stages of colon carcinogenesis via induction of aberrant crypt foci with enhanced growth phenotype. Can. J. Physiol. Pharmacol, 1998, 76, 1095. 

B. S. Reddy and K. Watanabe, Effect of cholesterol metabolites and promoting effect of lithocholic acid in colon carcinogenesis in germ-free and conventional F344 rats. Cancer Res., 1979, 39, 1521. 

J. P. Cruse, M. R. Lewin and C. G. Clark, The effects of cholic acid and bile salt binding agents on 1,2-dimethylhydrazine-induced colon carcinogenesis in the rat. Carcinogenesis, 1981, 2, 439. 

J. E. Oscarson, H. F. Veen, J. S. Ross and R. A. Malt, Ileal resection potentiates 1,2-dimethylhydrazine-induced colonic carcinogenesis, Ann. Surg., 1979, 189, 503. 

H. Kohno, R. Suzuki, Y. Yasui, S. Miyamoto, K. Wakabayashi and T. Tanaka, Ursodeoxycholic acid versus sulfasalazine in colitis-related colon carcinogenesis in mice, Clin. Cancer Res., 2007, 13, 2519. 

Craven PA, DeRubertis FR (1992) Alterations in protein kinase C in 1,2-dimethylhydrazine induced colonic carcinogenesis. Cancer Res 52 2216-2221... 

Kawamori T, Rao CV, Seibert K, et al. Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis. Cancer Res 1998 58 409-412. 

K. Watanabe, T. Kawamori, S. Nakatsugi, T. Ohta, S. Ohuchida, H. Yamamoto, T. Maruyama, K. Kondo, F. Ushikubi, S. Narumiya, T. Sugimura, K. Wakabayashi, Role of the prostaglandin E receptor subtype EP1 In colon carcinogenesis. Cancer Res. 59 (1999) 5093. 

GN170 Quilliot, D., F. Boman, C. Creton, X. Pelletier, J. Floquet, and G. Debry. Phytosterols have an unfavourable effect on bacterial activity and no evident protective effect on colon carcinogenesis. Eur J Cancer Prev 2001 10(3) 237-243. 

Navarro, et al. Effect of olive oil on early and late events of colon carcinogenesis in rats modulation of arachi-donic acid metabolism and local prostaglandin E2 synthesis. Gut 2000 46(2) 191-199. 

POZHARISSKI, K.M. (1975). The significance of nonspecific injury for colon carcinogenesis in rats, Cancer Res. 35,3284. 

Groups of A/J and C57BL/6J strains, their F, progeny and 23 recombinant inbred strains, at eight weeks of age, received 20 weekly subcutaneous injections of 15 mg/kg bw 1,2-dimethylhydrazine. The animals were killed six weeks after the last 1,2-dimethylhydrazine injection. The analysis of colon tumour incidence led to the conclusion that there are several or many mechanisms in colon carcinogenesis and each of them requires several if not many genes for its functioning (Fleiszer et al., 1988). 

Autrup, H., Harris, C.C., Sehwartz, R.D., Trump, B.F. Smith L. (1980a) Metabolism of 1,2-dimethylhydrazine by eultured human colon. Carcinogenesis, 1, 375-380... 

Fleiszer, D., Hilgers, J. Skamene, E. (1988) Multigenic control of colon carcinogenesis in mice treated with 1,2-dimethylhydrazine. Curr. Top. Microbiol. Immunol.. 137, 243-249... 

Jacobs. L.R. Lupton, J.R. (1986) Relationship between colonic luminal pH, cell proliferation, and colon carcinogenesis in 1,2-dimethylhydrazine treated rats fed high fiber diets. Cancer Res.. 46, 1727-1734... 

Reddy, B.S., Weisburger, J.H., Narisawa, T. Vender, E.L. (1974) Colon carcinogenesis in germ-free rats with 1,2-dimethylhydrazine and A-methyl-V -nitro-A-nitrosoguanidine. Cancer Res., 34, 2368-2372... 

Reddy, B.S., Narisawa, T. Weisburger, J.H. (1976) Colon carcinogenesis in genn-free rats with... 

---