Prevention, cancer

However, already in an early clinical trial, rofecoxib was found to produce four times the number of myocardial infarctions than its comparator drug, naproxen. A subsequent trial of rofecoxib compared to placebo in colorectal cancer prevention demonstrated, after 18 months of study, that a greater number of myocardial infarctions occulted in the rofecoxib group. In 2004 the manufacturers of rofecoxib withdrew the diug from the market. A similar study of celecoxib compared to placebo in cancer prevention, showed that celecoxib also increased the risk of cardiovascular embolisms [3]. [Pg.406]

Isotretinoin COOH Topical 0.05% cream Oral 0.251.0 mg/kg/ d Cystic acne, recalcitrant nodular acne Rosacea gram-negative folliculitis pyoderma faciale hidradenitis suppurativa cancer prevention... [Pg.1074]

STAR trial (Study of tamoxifen and raloxifene), which was completed in 2006, demonstrated additional utility of raloxifene in the prevention and treatment of breast cancer. In fact, the absence of associated uterotrophic effects with raloxifene suggests that it may be a safer agent than tamoxifen for use as a chemopreventative in high-risk postmenopausal women [3] therefore, raloxifene has very recently become a new option for breast cancer prevention now available for physicians and their patients. [Pg.1116]

Pham DQ, Plakogiannis R (2005) Vitamin E supplementation in cardiovascular disease and cancer prevention Part 1. Ann Pharmacother 39 1870-1878... [Pg.1298]

Nixon DW, Zang EA, McShane P, Ferretti A, Ferguson L, Gardnet R. The South Carolina prostate cancer prevention and telehealth program. Controlled Clin Trials 2003 P31. [Pg.629]

Department of Biochemistry, Brandeis University, Waltham, MA 02254 Cancer Prevention Division, National Cancer Center Research Institute, Chuo-ku, Tolgro 104, Japan... [Pg.224]

The a-tocopherol, P-carotene (ATBC) Cancer Prevention study was a randomised-controlled trial that tested the effects of daily doses of either 50 mg (50 lU) vitamin E (all-racemic a-tocopherol acetate), or 20 mg of P-carotene, or both with that of a placebo, in a population of more than 29,000 male smokers for 5-8 years. No reduction in lung cancer or major coronary events was observed with any of the treatments. What was more startling was the unexpected increases in risk of death from lung cancer and ischemic heart disease with P-carotene supplementation (ATBC Cancer Prevention Study Group, 1994). Increases in the risk of both lung cancer and cardiovascular disease mortality were also observed in the P-carotene and Retinol Efficacy Trial (CARET), which tested the effects of combined treatment with 30 mg/d P-carotene and retinyl pahnitate (25,000 lU/d) in 18,000 men and women with a history of cigarette smoking or occupational exposure to asbestos (Hennekens et al, 1996). [Pg.33]

One other study deserves a mention. The Cancer Prevention Study 11 was a prospective investigation using a very large cohort of over one million adult Americans, in which the effects of commercial multivitamin supplements and vitamins A, C or E on mortality were studied, during a follow-up period of seven years. The results were complex in that the use of multivitamins plus vitamins A, C and/or E significantly reduced the risk of lung cancer in both former smokers and life-long non-smokers, but vitamins A, C and E apparently increased the risk in current smokers. [Pg.34]

ALBANES D, HEINONEN O P, HUTTUNEN J K, TAYLOR P R, VIRTAMA J, EDWARDS B K, HAAPAKDSKI J, RAUTALATHI M, HARTMAN A M and PALMGREN J (1995) Effects of alpha-tocopherol and beta carotene supplements on cancer incidence in the alpha-tocopherol beta-carotene cancer prevention study , Am J Clin Nutr, 62, 1427S-30S. [Pg.39]

ALPHA-TOCOPHEROL BETA-CAROTENE (ATBC) CANCER PREVENTION STUDY GROUP (1994) The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers , New Engl J Med, 330, 1029. [Pg.39]

BLOCK G (1991) Vitamin C and cancer prevention the epidemiologic , Am. 1 Clin Nutr, 53, 270S-82S. [Pg.40]

BLOCK G, PATTERSON B and SUBAR A (1992) Fruit, vegetables, and cancer prevention a review of the epidemiological evidence , Nutr Cancer, 18, 1-29. [Pg.40]

BYERS T and GUERRERO N (1995) Epidemiologic evidence for vitamin C and vitamin E in cancer prevention , Am J Clin Nutr, 62, 1385S-92S. [Pg.40]

CHOPRA M, MCLOONE u L, o neill m, WILLIAMS N and THURNHAM DI (1996) Fruit and vegetable supplementation - effect on ex vivo LDL oxidation in hiunans , in Kumpulainen, J T and Saonen, J T (eds), Natural Antioxidants and Food Quality in Atherosclerosis and Cancer Prevention, Cambridge, Royal Society of Chemistry, 150-55. [Pg.40]

RIBOLI E and NORAT T (2001) Cancer prevention and diet opportunities in Europe , Public Health Nutrition, 4, 475-84. [Pg.43]

STEINMETZ K A and POTTER J D (1996) Vegetables, fruit, and cancer prevention a review , J Am Diet Assoc, 96, 1027-39. [Pg.43]

VAN POPPED G and goldbohm r a (1995) Epidemiological evidence for heta-carotene and cancer prevention , J Am Clin Nutr, 62, 1393S-402S. [Pg.43]

KIRLIN w G, CAi J, DELONG M J, PATTEN E J and JONES D P (1999) Dietary compoimds that induce cancer preventive phase 2 enzymes activate apoptosis at comparable doses in HT29 colon carcinoma cells , JNutr, 129 1827-35. [Pg.64]

It is well known that excessive intake of P-carotene may lead to carotenodermia (yellow skin), and it is undoubtedly the case that some carotenoid is directly lost via the skin or through photo-oxidation in the skin. As far as is known the carotenoids are not cytotoxic or genotoxic even at concentrations up to 10 times the normal plasma concentration which may cause carotenodermia. However, they are associated with amenorrhoea in girls who may be consuming bizarre diets and, in long-term supplementation studies, with an increase in lung cancer (The Alpha-tocopherol, Beta-carotene Cancer Prevention Study Group, 1994). [Pg.119]

FUJiKi H (1999) Two stages of cancer prevention with green tea , J Cancer Res Clin Oncol, 125, 589-97. [Pg.152]

SUGANUMA M, OKABE s, KAi Y, suEOKA N, suEOKA E and FUJiKi H (1999) Synergistic effects of (-)-epigallocatechin gallate with (-)-epicatechin, sulindac, or tamoxifen on cancer-preventive activity in human lung cancer cell line PC-9 , Cancer Res, 59, 44-7. [Pg.157]

BiRT D F, HENDRicH s and WANG w (2001) Dietary agents in cancer prevention flavonoids and iso flavonoids. Pharmacol Then 90 (2-3) 157-77. [Pg.212]

ALBANES D, HEiNONEN o p, TAYLOR p R, et uL, (1996) a-tocopherol and P-carotene supplementation and Irmg cancer incidence in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study effect of base-line chacteristics and study compliance. J Natl Cancer Inst. 88 1560-70. [Pg.236]

Ferruzzi, M.G. and Blakeslee, J., Digestion, absorption and cancer preventative activity of dietary chlorophyll derivatives, Nutr. Res., 21, 1, 2007. [Pg.48]

Beta-Carotene Cancer Prevention Study) Gastric cancer 0 45... [Pg.130]

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