Cancer prevention/therapy resveratrol

Chemoprevention is an emerging and promising approaeh to control human cancer. Several natnral products have been proven to have potentials as anticancer agents. Resveratrol is one such compound. Recently, increasing interest has focused on examining the effect of resveratrol in breast cancer prevention and treatment. The present review summarizes the recent studies on the role of resveratrol in cancer prevention and therapy, especially in human breast cancer, that provide new insights into the molecular mechanisms of resveratrol. The estrogenic activity of resveratrol, as well as its in vitro and in vivo antiproliferative and chemoprotective activities, will be discussed here. 

It has been reported that resveratrol presented other benefits in other organs. These pharmacological and therapeutic properties strengthen the concept that resveratrol supplements may be considered in future strategies of using natural products in cancer prevention and therapy. However, appropriate long-term clinical trials will have to be conducted before any final conclusions can be made about the potential benefit of resveratrol as a chemopreventive agent. 

Sarkar FH, Adsule S, Padhye S, Kulkami S, Li Y (2006) The role of genistein and synthetic derivatives of isoflavone in cancer prevention and therapy. Mini Rev Med Chem 6 401 07 Whitsett TG Jr, Lamartiniere CA (2006) Genistein and resveratrol mammary cancer che-moprevention and mechanisms of action in the rat. Expert Rev Anticancer Ther 6 1699-1706... 

Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S, Takada Y. 2004. Role of resveratrol in prevention and therapy of cancer Preclinical and clinical studies. Anticancer Res 24 2783-2840. 

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