Natural products/supplements prevention, cancer

It has been reported that resveratrol presented other benefits in other organs. These pharmacological and therapeutic properties strengthen the concept that resveratrol supplements may be considered in future strategies of using natural products in cancer prevention and therapy. However, appropriate long-term clinical trials will have to be conducted before any final conclusions can be made about the potential benefit of resveratrol as a chemopreventive agent. 

There are discordant results between the effects of vitamin E supplements in observational studies, in which they seem to reduce the risk of cardiovascular disease, and the results of interventional studies, in which they seem to have the opposite effect. In an extensive review of the benefits and adverse effects of vitamin E, the authors, employees of IdeaSphere Inc., which markets vitamins and nutrients, concluded that healthy consumers should not change their current use of vitamin E supplements since most of the studies included in the three recent neutral to unfavorable meta-analyses were not conducted on free-living healthy individuals. .. [and] only four of 28 studies included in these meta-analyses involved healthy individuals [45 ]. They urged that the guidelines set forth by the Institute of Medicine [in 2000] should still be embraced and that healthy individuals should not use more than 1000 mg of vitamin E daily . They concurred with the findings of the HOPE study, a randomized, placebo-controlled study of the use of vitamin E 400 lU/day over 7 years [46 ], that vitamin E did not prevent cancer or major cardiovascular disease events in subjects with pre-existing vascular disease or diabetes mellitus, and may have increased the risk of heart failure, and that, as the authors of the HOPE study concluded, such individuals should be warned to beware of natural products . 

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