Brandeis University

In 1967, work was presented from a Sheffield group on indexing chemical reactions for database budding. In 1969, a Harvard group presented its first steps in the development of a system for computer-assisted synthesis design. Soon afterwards, groups at Brandeis University and TU Munich, Germany, presented their work in this area. 

X-ray studies at 22.5 A resolution of murine polyomavlrus by 1. Rayment and D.L.D. Caspar at Brandeis University confirmed the presence of these 72 capsomers at the expected positions, but even at low resolution the pentagonal shape of all 72 capsomers was evident (Figure 16.22). They concluded that each capsomer must be a pentameric assembly of the major viral subunit, known as viral protein 1 (VPl). Each of the 60 icosahedral asymmetric units contains 6 VPl subunits, not 7, and the complete shell contains 360 VPl subunits. The 12 VPl pentamers centered on icosahedral fivefold axes are identically related to their five neighbors, but the 60 pentamers centered on pseudosixfold positions "see" each of their 6 neighbors quite differently (Figure 16.23). How can such diversity of interaction be incorporated into the bonding properties of just one type of protein subunit, without compromising specificity and accuracy of assembly ... 

The following, in alphabetical order, have reviewed one or more chapters, correcting our errors of fact or interpretation and helping to ensure they have the appropriate balance and emphasis Tom Alber (University of California, Berkeley), Tom Blundell (Cambridge University, UK), Stephen Burley (Rockefeller University), Charles Craik (University of California, San Francisco), Ken Dill (University of California, San Francisco), Chris Dobson (Oxford University, UK), Anthony Fink (Unversity of California, Santa Cruz), Robert Fletterick (University of California, San Francisco), Richard Henderson (LMB, Cambridge, UK), Werner Kiihlbrandt (MPI, Frankfurt), David Parry (Massey University, New Zealand), Greg Petsko (Brandeis University), and David Trentham (NIMR, London, UK). 

FIGURE 17.12 Electron micrograph of a skeletal muscle myofibril (in longitndinal section). The length of one sarcomere is indicated, as are the A and I bands, the H zone, the M disk, and the Z lines. Cross-sections from the H zone show a hexagonal array of thick filaments, whereas the I band cross-section shows a hexagonal array of thin filaments. (Photo courtesy of Hugh Huxley, Brandeis University)... 

Department of Biochemistry, Brandeis University, Waltham, MA 02254 Cancer Prevention Division, National Cancer Center Research Institute, Chuo-ku, Tolgro 104, Japan... 

Brandeis University, 224 Brigham and Women s Hospital, 23,202 Centre National de la Recherche Scientifique, 192,290 Colorado State University, 336 Cornell University, 144 Harvard Medical School, 2,29,202 Institut National de la Sant et de la Recherche Mddicale, 192 Lawrence Berkeley Laboratory, 290 Massachusetts Institute of Technology, 204 Medical College of Georgia, 107 Mitsubishi Kasei Institute of Life Sciences, 133,219 Nagoya University, 232 National Cancer Center Research Institute, 204,224,232 National Institutes of Health, 347 New York Aquarium, 347 New York University, 304,347 The Salk Institute, 256... 

Peter C. Jordan Department of Chemistry, Brandeis University, Waltham, Massachusetts... 

Laurie Nsiah-Jefferson, M.P.H., Heller School for Social Policy and Management, Brandeis University, Waltham, MA Allen C. Nnnnally, J.D., Hale and Dorr LLP, Boston, MA... 

DR. KENNETH KUSTIN (Brandeis University) Some years ago, you studied reactions of the type MX + Y = MY + X and found some interesting effects, such as chain reactions and phenomena of that sort. You also found that there was autocatalysis of such ligand substitution reactions by, I believe, triglycine. Has that turned up again Are other tripeptides or polypeptides autocatalytic How does that fit in with the base catalysis concept ... 

DR. KENNETH KUSTIN (Brandeis University) When a table or a chart contains only activation parameters, one loses sight of what is actually going on in the system. When you recall that... 

DR. KENNETH KUSTIN (Brandeis University) You mentioned that perchlorate is resistant to attack by the hydrated electron. I think that is even more remarkable when you realize that a similarly usually inert anion, nitrate, is rapidly attacked by the hydrated electron. Even though the hydrated... 

DR. KENNETH KUSTIN (Brandeis University) How can you distinguish experimentally between a reaction on the surface of the micelle and one in the interior of the micelle ... 

TPPS (sodium salt) was obtained from Strem Chemicals and used as received. TTAP and some of its metal-substituted derivatives were kindly by Dr. E. Ojadi of Brandeis University. The other porphyrins used in this study were synthesized following published procedures (14,U). 

Paul Anastas was born in Quincy, Massachusetts, on May 16, 1962. He attended the University of Massachusetts at Boston, from which he earned his B.S. degree in chemistry in 1984. He then studied at Brandeis University, outside Boston, where he earned his M.A. in 1987 and his Ph.D. in organic chemistry in 1989. His first job was as a consultant to chemical industries on the development of new analytical and synthetic chemical processes. 

Department of Biochemistry Brandeis University Waltham, Massachusetts 02254... 

Electron micrograph of a striated muscle sarcomere showing the appearance of filamentous structures when cross-sectioned at the locations illustrated below. (Electron micrograph courtesy of Dr. Hugh Huxley, Brandeis University.)... 

Received May 14, 1965. Supported by a grant from the U. S. Atomic Energy Commission to Brandeis University (No. AT-30-1-2003). 

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