Aspirin cancer prevention

Tait CR (2004) Aspirin and breast cancer prevention a link to ER status. Breast Cancer Res 6 211-212... 

Asphalt chemicals, ethyleneamines application, 8 500t, 506 Asphalt emulsifier amine oxides, 2 473 fatty acid amides, 2 458 Asphalt emulsions, 10 131 Asphaltenes, in petroleum vacuum residua, 18 589-590 Asphyxiants, 21 836 Aspirating aerators, 26 165-169 compressed, 26 168-169 propeller driven, 26 168 submersible, 26 169, 170t subsurface, 26 168 Aspiratory, 11 236-237 Aspirin, 4 103-104, 104t, 701 22 17-21. See also Acetylsalicylic acid as trade name, 22 19 for cancer prevention, 2 826 Aspirin resistance, 4 104 ASP oil recovery process, 23 532-533 Assay format, competitive, 14 142 Assay limits, in Investigational New Drug Applications, 18 692 Assays, for silver, 22 650. See also... 

Williams CS, Smalley W, DuBois RN. Aspirin use and potential mechanisms for colorectal cancer prevention. J Clin Invest 1997 100 1325-1329. 

Gupta RA, DuBois RN. Aspirin, NS AID, and colon cancer prevention mechanisms Gastroenterology 1998 114 1095-1100. 

Aspirin A drug that reduces pain, fever, inflammation, and hlood clotting. Aspirin belongs to the family of drugs called nonsteroidal anti-inflammatory agents. It is also being studied in cancer prevention, [nih]... 

Lynch snggests that CRC is an excellent model for investigating cancer prevention throngh means of secondary approaches snch as polypectomy for removal of precursor colonic adenomas as well as primary (chemoprevention) strategies. Attention was appropriately called to the manner in which the regular use of aspirin and other NSAIDs has led to a reduction in risk of CRC. Herein, a possible mechanism from this beneflt relates to the mentioned decreased prostaglandin production,... 

Sandler, R.S., Halabi, S., Baron, J.A., Budinger, S., Paskett, E., Keresztes, R. et al., A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer. New England J. Med., 348,883-890,2003. 

Wilt TJ, MacDonald R, Hagerty K et al. (2008) Five-alpha-reductase inhibitors for prostate cancer prevention. Cochrane Database 8yst Rev CD007091 Zhang SM, Cook NR, Manson JE et al. (2008) Low-dose aspirin and breast cancer risk results by tumour characteristics from a randomised trial. Br J Cancer 98 989 991... 

The understanding of these actions of aspirin started in 1971 (45) and resulted in the recommendations of the medical community that small doses of aspirin, used under the care of the doctor, may be a prevention measure for heart attack, and stroke for those considered at risk in the population. Further reported work may expand health benefits to prevention of certain kinds of cancer (46). 

Non-steroidal anti-inflammatory agents, aspirin, and acetaminophen have been suggested for use in the prevention of different cancers, especially hereditary non-polyposis colon cancer.14 While there have been observational studies linked to a reduction of ovarian carcinoma risk, evidence is still lacking. Potential... 

In addition to their beneficial effects, some medications may actually cause cellular injury and disease. An example of this phenomenon involves nonsteroidal anti-inflammatory drugs (NSAIDS). These drugs include aspirin (a derivative of salicylic acid), ibuprofen (arylpropionic acid, Advil ), and acetaminophen (para-aminophenol derivative, Tylenol ). Because of their beneficial pharmacological effects, consumption of these agents has increased significantly in recent years. NSAIDS have the ability to treat fever, pain, acute inflammation, and chronic inflammatory diseases such as arthritis. They are also used prophylactically to prevent heart disease, stroke, and colon cancer. 

Giovannucci E. The prevention of colorectal cancer by aspirin use. Biomed Pharmacother 1999 53 303-308. 

There is now considerable evidence that regular aspirin use decreases the risk of colorectal cancer.1,49,58 It has been estimated, for example, that people who use aspirin on a regular basis have a 40 to 50 percent lower risk of fatal colon cancer as compared with people who do not use aspirin.78 Aspirin might also help prevent other types of cancers (e.g., skin, bladder, prostate can-... 

Moyad MM An introduction to aspirin, NSAids, and COX-2 inhibitors for the primary prevention of cardiovascular events and cancer and their potential preventive role in bladder carcinogenesis part II. Semin Urol Oncol. 2001 19 306-316. 

Aspirin, now commonly used for prevention of CHD and colon cancer, combined with butyrate exerted stronger anti-proliferate and pro-apoptotic effects than either alone. 

It has recently been reported that aspirin can also help in the prevention of prostate cancer in males. Research on this possible use is continuing. 

In secondary prevention the patient has the disease and the objective is to reduce risk factors and to retard progression (e.g. aspirin and lipid-lowering drugs in atherosclerosis and post-myocardial infarction). In breast cancer, the use of tamoxifen, which can itself rarely cause endometrial cancer (which is detectable and treatable), raises complex scientific and socioeconomic issues. 

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