Lung cancer cell lines

OKABE s, SUGANUMA M, HAYASHi M, SUEOKA E, KOMORI A and FUJIKI H (1997) Mechanisms of growth inhibition of hmnan lung cancer cell line, PC-9, by tea polyphenols , Jpn J Cancer Res, 88 (7), 639-43. 

SUGANUMA M, OKABE s, KAi Y, suEOKA N, suEOKA E and FUJiKi H (1999) Synergistic effects of (-)-epigallocatechin gallate with (-)-epicatechin, sulindac, or tamoxifen on cancer-preventive activity in human lung cancer cell line PC-9 , Cancer Res, 59, 44-7. 

Fukunaga, Y., Bandoh, S., Fujita, J., Yang, Y., Ueda, Y., Hojo, S., Dohmoto, K., Tojo, Y., Takahara, J., Ishida, T. (2002). Expression of cytokeratin 8 in lung cancer cell lines and measurement of serum cytokeratin 8 in lung cancer patients. Lung Cancer 38(1), 31-38. 

Cole SPC, Bhardwaj G, Gerlach J, Mackie J, Grant C, Almquist K et al. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 1992 258 1650-1654. 

Mirski, S.E., Gerlach, J.H. and Cole, S.P. (1987) Multidrug resistance in a human small cell lung cancer cell line selected in adriamycin. Cancer Research, 47, 2594-2598. 

Roche has reported a 2,4-diaminopyrimidine 42 (Ro-4584820) to be a Phase I clinical candidate [48,103]. Compound 42 is a pan-CDK inhibitor (CDKl K = 0.001 ptM CDK2 K[ = 0.003 p.M CDK4 K[ = 0.001 p.M), consequently it induces both G1 and G2 cell cycle arrest in tumor cell lines. It is a potent inhibitor of tumor cell proliferation in both the HCT-116 colon cancer (IC50 = 0.080 tiM) and the H460A (IC50 = 0.055 p.M) lung cancer cell lines. 

Kim CY, Giaccia AJ, Strulovici B, Brown JM (1992) Differential expression of protein kinase C epsilon protein in lung cancer cell lines by ionising radiation. Br Cancer 66 844-849... 

Shimizu E, Zhao MR, Nakanishi H, Yamamoto A, Yoshida S, Takada M, Ogura T, Sone S (1996) Differing effects of staurosporine and UCN-01 on RB protein phosphorylation and expression of lung cancer cell lines. Oncology 53 494-504... 

Tsai CM, Chang KT, Wu LH, Chen JY, Gazdar AF, Mitsudomi T, Chen MH, Perng RP (1996) Correlations between intrinsic chemoresistance and HER-2/neu gene expression, p53 gene mutations, and cell proliferation characteristics in non-small cell lung cancer cell lines. Cancer Res 56 206-209 Oberall F, Oberhuber H, Maly K, Zaknun J, Demuth L, Grunicke HH (1991) Hexade-cylphosphocholine inhibits inositol phosphate formation and protein kinase C activity. Cancer Res 51 807-812... 

Fig. 2. The radiation sensitizing effects of paclitaxel and concurrent ionizing radiation in a human lung cancer cell line, HL-60. From ref. 40.

Soriano AF, Helfrich B, Chan DC, et al. Synergistic effects of new chemopreventive agents and conventional cytotoxic agents against human lung cancer cell lines. Cancer Res 1999 59 6178-6184. 

Hida T, Kozaki K, Muramatsu H, et al. Cyclooxygenase-2 inhibitor induces apoptosis and enhances cytotoxicity of various anticancer agents in non-small cell lung cancer cell lines. Clin Cancer Res 2000 6 2006-2011. 

Integral plasma membrane proteins from a human lung cancer cell line (62 prenylated proteins and 45 Ras family proteins) urinary proteins AGP-derived glycoproteins major and minor populated isoforms of antithrombin regulatory lipids in breath condensate ... 

Janne PA, Li C, Zhao X et al. High-resolution single-nucleotide polymorphism array and clustering analysis of loss of heterozygosity in human lung cancer cell lines. Oncogene 2004 23 2716-2726. 

Coldren CD, Helfrich BA, Witta SE et al. Baseline gene expression predicts sensitivity to gefitinib in non-small cell lung cancer cell lines. Mo/ Cancer Res 2006 4 521-528. 

Witta SE, Gemmill RM, Hirsch FR et al. Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines. Cancer Res 2006 66 944-950. Walker F, Kato A, Gonez LJ et al. Activation of the Ras/mitogen-activated protein kinase pathway by kinase-defective epidermal growth factor receptors results in cell survival but not proliferation. Mol Cell Biol 1998 18 7192-7204. 

A study of Laurencia tristicha from the South China Sea has discovered the hydroxylated aplysins, 10-hydroxyepiaplysin (406) and 10-hydroxyaplysin (407) (602), and 4-bromo-l,l-epoxylaur-ll-ene (408), which was previously synthesized but not found naturally (603). Laurencia microcladia from the North Aegean Sea has yielded the new 409 and 410, which exhibit significant cytotoxicity against two lung cancer cell lines (604). This red alga also contains the dimeric cyclolaurane 411 (595). An East China Sea collection of Laurencia okamurai has led to the isolation of the novel laureperoxide (412) and 10-bromoisoaplysin (413)... 

Sagawa, N., H. Fujita, Y. Banno, Y. Nozawa, H. Katoh, and N. Kuzumaki. 2003. Gelsolin suppresses tumorigenicity through inhibiting PKC activation in a human lung cancer cell line, PC10. Br J Cancer. 88 606-12. 

S100A14 was identified and characterised by analysing a human lung cancer cell line subtraction cDNA library (Pietas et al., 2002). It encodes an mRNA present... 

Frederiksen KS, Abrahamsen N, Cristiano RJ, Damstrup L, Poulsen HS (2000) Gene delivery by an epidermal growth factor/DNA polyplex to small cell lung cancer cell lines expressing low levels of epidermal growth factor receptor. Cancer Gene Ther 7 262-268... 

A method has been proposed for the determination of cellular levels in lung cancer cell lines of the TKIs dasatinib and lapatinib [141], Cellular samples were extracted with a mixture of tert-butyl methyl ether/ACN/ammonium formate pH 3.5 (6 2 1, v/v/v). The organic layer was subjected to evaporation and the samples were reconstituted in acetonitrile, followed by chromatographic separation on a C18 column. Dasatinib and lapatinib were monitored by tandem MS equipped with a positive electrospray ionization interface in positive ion mode. These cellular experiments showed that lapatinib is not actively expelled from P-gp over-expressing cancer cells, while P-gp activity significantly decreases cellular levels of dasatinib [141],... 

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