Tumor necrosis factor-alpha genes

Boin, F. et al., Association between -G308A tumor necrosis factor alpha gene polymorphism and schizophrenia, Mol. Psychiat., 6, 79, 2001. 

Sakao, S. et al., Association of tumor necrosis factor alpha gene promoter polymorphism with the presence of chronic obstructive pulmonary disease, Am. J. Respir. Crit. Care Med., 163,420, 2001. 

Mugnier, B., Balandraud, N., Darque, A., Roudier, C., Roudier, J., and Reviron, D. (2003) Polymorphism at position -308 of the tumor necrosis factor alpha gene influences outcome of infliximab therapy in rheumatoid arthritis. Arthritis and Rheumatism. 48, 1849-1852. 

Sharma A, Mani S, Hanna NN, et al. An open-label, phase 1, dose-escalation study of tumor necrosis factor-alpha gene transfer (TNFerade) with radiation therapy for locally advanced, recurrent, or metastatic solid tumors. Hum Gene Ther2001 12(9) 1109-1131. 

Corbett, E. L., N. Mozzato-Chamay, A. E. Butterworth, K. M. De Cock, B. G. Williams, G. J. Churchyard, and D. J. Conway. 2002. Polymorphisms in the Tumor Necrosis Factor-Alpha Gene Promoter May Predispose to Severe Silicosis in Black South African Miners. American fournal of Respiratory and Critical Care Medicine 165 690-693. 

Senzer N, Mani S, Rosemurgy A, Nemunaitis J, et al. 204. TNFerade biologic, an adenovector with a radiation-inducible promoter, carrying the human tumor necrosis factor alpha gene A phase I study in patients with solid tumors. J Clin Oncol. 22 592-601. 

Kowalski J, Samojedny A, Paul M, Pietsz G, Wilczok T. 2005. Effect of apigenin, kaempferol and resveratrol on the expression of interleukin-1 beta and tumor necrosis factor-alpha genes in J774.2 macrophages. Pharmacol Rep 57 390-394. 

Corbett EL, Mozzato-Chamay N, Butterworth AE, De Cock KM, Williams BG, Churchyard GJ, Conway DJ (2002) Polymorphisms in the tumor necrosis factor-alpha gene promoter may predispose to severe silicosis in black South African miners. Am J Respir Crit Care Med, 165 690-693. 

F31. Fugger, L., Morling, N., Sandberg Wollheim, M., Ryder, L. P., and Svejgaard, A. Tumor necrosis factor alpha gene polymorphism in multiple sclerosis and optic neuritis. J. Neuroimmunol. 27, 85-88 (1990). 

Nair MP, Mahajan S, Reynolds JL, Aalinkeel R, Nair H, Schwartz SA, Kandaswami C (2006) The flavonoid quercetin inhibits proinflammatory cytokine (tumor necrosis factor alpha) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-kappa beta system. Clin Vaccine Immunol 13(3) 319-328. doi 10.1128/CVI. 13.3.319-328.2006, 13/3/319 [pii]... 

Whyte M, Hubbard R, MeUconi R, et al. Increased risk of fibrosing alveoUtis associated with interleukin-1 receptor antagonist and tumor necrosis factor-alpha gene polymorphisms. Am J Respir Crit Care Med 2000 162(2 pt l) 755-758. 

Bennett, B.L., Cruz, R., Lacson, R.G. and Manning, A.M. (1997) Interleukin-4 suppression of tumor necrosis factor alpha-stimulated E-selectin gene transcription is mediated by STAT6 antagonism of NF-kappaB. Journal of Biological Chemistry 272, 10212-10219. 

Hofbauer LC, Lacey DL, Dunstan CR, Spelsberg TC, Riggs BL, Khosla S (1999) Interleukin-lbeta and tumor necrosis factor-alpha, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells. Bone 25 255-259... 

Vidigal, P. G., Germer, J. J., and Zein, N. N., Polymorphisms in the interleukin-10, tumor necrosis factor-alpha, and transforming growth factor-betal genes in chronic hepatitis C patients treated with interferon and ribavirin, J. Hepatol., 36, 271, 2002. 

Mauceri HJ, Hanna NN, Wayne JD, et al. Tumor necrosis factor alpha (TNF-alpha) gene therapy targeted by ionizing radiation selectively damages tumor vasculature. Cancer Res 1996 56 4311-4314. 

Kahari, V. M., Chen, Y. Q., Bashir, M. M., Rosenbloom, J., and Uitto, J. (1992). Tumor necrosis factor-alpha down-regulates human elastin gene expression. Evidence for the role of AP-1 in the suppression of promoter activity. J. Biol. Chem. 267, 26134-26141. 

Qin, L., Ding, Y., Pahud, D.R., Chang, E., Imperiale, M.J. and Bromberg, J.S. (1997) Promoter attenuation in gene therapy interferon-gamma and tumor necrosis factor-alpha inhibit transgene expression. Hum. Gene Then, 8, 2019-2029. 

Very little work has been reported on the role of oxidative stress in osteoblasts. However, osteoblasts can be induced to produce intracellular ROS (Cortizo et al., 2000 Liu et al., 1999), which can cause a decrease in alkalinephosphatase (ALP) activity that is partially inhibited by vitamin E and cause cell death (Cortizo et al., 2000 Liu et al., 1999). Treatment of rat osteosarcoma ROS 17/2.8 cells with tumor necrosis factor-alpha (TNF-a) suppressed bone sialoprotein (BSP) gene transcription through a tyrosine kinase-dependent pathway that generates ROS (Samoto et al., 2002). H202 modulated intracellular calcium (Ca2+) activity in osteoblasts by increasing Ca2+ release from the intracellular Ca2+ stores (Nam et al., 2002). 

Stehlik C, deMartin R, Kumabashiri I, Schmid JA, Binder BR, Lipp J. Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis. J Exp Med 1998 188 211-216. 

R. T. Jaggar, H. Y. Chan, A. L. Harris, and R. Bicknell, Endothelial cell-specific expression of tumor necrosis factor-alpha from the KDR or E-selectin promoters following retroviral delivery, Hum. Gene Ther. 8 2239 (1997). 

Lin J., Haruta A., Kawano H., Ho S.B., Adams G.L., Juhn S.K. and Kim Y. (2000) Induction of mucin gene expression in middle ear of rats by tumor necrosis factor-alpha potential cause for mucoid otitis media. J Infect Dis 182, 882-887 Madsen F., Eberth K. and Smart J.D. (1998) A Rheological examination of the Mucoadhe-sive/Mucus Interaction the Effect of Mucoadhesive Type and Concetration. J. Control Release 50, 167-178... 

Janssen U, Thomas G, Giant T, Phillips A. Expression of inter-alpha-trypsin inhibitor and tumor necrosis factor-stimulated gene 6 in renal proximal tubular epithelial cells. Kidney... 

Stehlik C, de Martin R, Kumabashiri I, Schmid JA, Binder BR, Lipp J (1998) Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis. J Exp Med 188 211-216 Stennicke HR, Deveraux QL, Humke EW, Reed JC, Dixit VM, Salvesen GS (1999) Caspase-9 ctin be activated without proteolytic processing. J Biol Chem 274 8359-8362 Sun XM, Butterworth M, MacFarlane M, Dubiel W, Ciechanover A, Cohen GM (2004) Caspase activation inhibits proteasome function during apoptosis. Mol Cell 14 81-93 Suzuki Y, Imai Y, Nakayama H, Takahashi K, Takio K, Takahashi R (2001) A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol Cell 8 613-621... 

Albensi BC, Mattson MP (2000) Evidence for the involvement of TNF and NF-kapptiB in hippocampal synaptic plasticity. Synapse 35 151-159 Baltimore D (1988) Gene therapy intraceUular immunization. Nature 335 395-396 Barger SW, Horster D, Furukawa K, Goodman Y, Krieglstein J et al (1995) Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation. Proc Natl Acad Sci USA 92 9328-9332... 

Russell JP, Diamond G, Tarver AP, Scanlin TB, Bevins CL Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha. Infect Immun 1996 64 1565-1568. 

Baatz JE, Zou Y, Korfhagen TR. Inhibitory effects of tumor necrosis factor-alpha on cationic lipid-mediated gene delivery to airway cells in vitro. Biochim Biophys Acta 2001, 1535, 100-109. 

D.K. Kalra, X. Zhu, M.K. Ramchandani, G. Lawric, M.J. Reardon, D. Lee-Jackson, W.L. Winters, N. Sivasubramanian, D.L. Mann and W.A. Zoghbi, Increased myocardial gene expression of tumor necrosis factor-alpha and nitric oxide synthase-2 a potential mechanism for depressed myocardial function in hibernating myocardium in humans, Circulation 105(13), 1537-1540 (2002). 

Grimble, R.F., Howell, W.M., O Reilly, G., Turner, S.J., Markovic, O., Hirrell, S., East, J.M., and Calder, P.C. 2002. The ability of fish oil to suppress tumor necrosis factor alpha production by peripheral blood mononuclear cells in healthy men is associated with polymorphisms in genes that influence tumor necrosis factor alpha production. Am. J. Clin. Nutr. 76, 454-459. 

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