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Potential drug targets

Microtubules are cytoskeletal polymers consisting of repeatii a/ -tubulin heterodimers and a variety of minor components known as microtubule-associated proteins which are important for the regulation and distribution of microtubules in the cell Microtubules play the key role in many vital cellular aaivities such as mitosis, intracellular vesicle tnmsport, o miza-tion and positioning of membranous organelles, and determination of cell shape and motility. [Pg.3]

Antimicrotubule agents represent a unique class of compounds in so far as their taiget does not involve nucleic acid synthesis or int ity. Antimicrotubule agents basically exploit the dynamic character the most prominent features of all microtubules (except stable microtubules of cilia and flagella) i.e., the rapid exchange of subunits between polymers and a soluble tubulin pool. This dynamic ins ility is described by four parameters the rates of polymerization and depolymerization, and the fiequendes of catastrophe (the transition from polymerization to depolymerization) and rescue (the transition from depolymerization to [Pg.3]

In conclusion, above studies provide valuable insights into multifactorial nature of oxyanion (arsenite) resistance in Leishmania. Several metabolic pathways and membrane transporters are implicated in the resistance phenotype. A recent report utilizing transcript profiling of arsenite [Pg.5]

GS and KGJ were supported by Junior/Senior Research Fellowship from Coundl for Scientific and Industrial Research, New Delhi, Govt, of India. The work was fimded by a grant from Council for Scientific and Industrial Research, New Delhi, Govt, of India. [Pg.6]

Russo R, Laguna F, Lopez-Velez R et al. Visceral leishmaniasis in those infected with HIV Clinical aspects and other opportunistic infections. Ann Trop Med Parasitol 2003 97 99-105- [Pg.6]

AA A1 A01.004 Memapsin-2 Potential drug target for Alzheimer s disease... [Pg.878]

CA C1 C01.033 Cathepsin L-like peptidase (Fasciola sp.) Potential drug target for liver fluke infection... [Pg.878]

CA C1 C01.036 Cathepsin K Potential drug target for control of osteoporosis... [Pg.878]

CA C1 C01.046 Falcipain-2 Potential drug target for malaria infection... [Pg.878]

CA C1 C01.050 Histolysain Potential drug target for amoebic dysentery... [Pg.878]

CA C1 C01.073 Peptidase 1 (mite) Potential drug target for asthma... [Pg.878]

CA C1 C01.075 Cruzipain Potential drug target for Chagas disease... [Pg.878]

CA C1 C01.079 Papain homologue (Theileria-type) Potential drug target for East coast fever and theileriosis... [Pg.878]

CA C1 C01.094 Giardain Potential drug target for Giardia parasitism... [Pg.878]

CD C14 C14.001 Caspase-1 Potential drug target for down-regulation of the inflammatory mediator, interleukin 1beta, which could ameliorate inflammation and endotoxic shock... [Pg.878]

CD C14 C14.003 Caspase-3 Potential drug target for cardiac ischemic injury... [Pg.878]

CD C14 C14.010 Caspase-9 Potential drug target for amyotrophic lateral sclerosis... [Pg.878]

CD C14 C14.012 Caspase-11 Potential drug target in lipopolysaccharide-induced septic shock... [Pg.879]

MA M10 M10.014 Membrane-type matrix m etallo pe pt id ase-1 Potential drug target for tumor cell invasion... [Pg.879]

MA M12 M12.210 ADAM 10 peptidase Potential drug target for demyelinating disease... [Pg.879]

MA M12 M12.221 ADAMTS4 peptidase Potential drug target for the treatment of osteoarthritis... [Pg.879]

PA S1 S01.156 Entero peptidase Potential drug target for acute pancreatitis... [Pg.880]

PA S1 S01.162 Kallikrein hK3 Potential drug target for prostatic and other cancers... [Pg.880]

PA S1 S01.281 Arginyl peptidase Potential drug target in corneal infection by Pseudomonas aeruginosa... [Pg.880]

SF S26 S26.001 Signal peptidase I Potential drug target for antibacterial agents... [Pg.881]

SF S26 S26.009 Signalase (eukaryote) 18 kDa component Potential drug target to suppress human coronavirus replication... [Pg.881]

Frick DN (2007) The hepatitis C virus NS3 protein a model RNA helicase and potential drug target. Curr Issues Mol Biol 9 1-20... [Pg.172]

An NMR screening strategy in which a small but diverse set of small molecules is screened against a potential drug target was recently described... [Pg.20]

Many diseases are characterized by the expression of specific proteins1 in some cases, malignant cells yield unique protein profiles when total cellular protein extracts are analyzed by proteomic methods such as two-dimensional gel electrophoresis or matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS).2 High-throughput proteomic studies may be useful to differentiate normal cells from cancer cells, to identify and define the use of biomarkers for specific cancers, and to characterize the clinical course of disease. Proteomics can also be used to isolate and characterize potential drug targets and to evaluate the efficacy of treatments. [Pg.235]

See other pages where Potential drug targets is mentioned: [Pg.2]    [Pg.3]    [Pg.585]    [Pg.769]    [Pg.878]    [Pg.878]    [Pg.878]    [Pg.878]    [Pg.878]    [Pg.878]    [Pg.880]    [Pg.881]    [Pg.917]    [Pg.1236]    [Pg.1510]    [Pg.86]    [Pg.356]    [Pg.303]    [Pg.150]    [Pg.87]    [Pg.144]    [Pg.319]    [Pg.334]   
See also in sourсe #XX -- [ Pg.39 , Pg.41 ]



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