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Negative regulators

The Gpy dimer appears to function as a rigid unit with critical residues positioned to interact with Ga-GDP. Whereas Ga activation proceeds through nucleotide-dependent structural reorganization, activation of Gpy occurs solely as a function of its release from Ga. As we will see, the Ga subunit acts as a negative regulator of Gpy by masking sites on the surface of Gpy that interact with downstream effector molecules. [Pg.264]

A receptor on nerve endings within a synapse that responds to the released neurotransmitter from that neuron. This then feeds back to the same neuron and negatively regulates the synthesis and release of that neurotransmitter. [Pg.243]

Negative regulation of apoptosis is effected by inhibitor of apoptosis proteins. Another means of controling apoptosis is by altering the stabilization of mitochondria, which is largely determined by the interplay between the pro- and antiapoptotic members of the Bcl2 family [4]. [Pg.318]

Sherr CJ, Roberts JM (1999) CDK inhibitors positive and negative regulators of G1-phase progression. Genes Dev 13 1501-1512... [Pg.345]

Tumor necrosis factor alpha (TNFa) is a negative regulator of FATP expression and downregulates FATP mRNA and protein levels in several tissues. [Pg.498]

PIP2/membrane Negative regulation Choline interaction ... [Pg.969]

Sarcoplasmic calcium ATPase this enzyme utilizes the energy gained from hydrolysis of ATP to pump calcium from the cytosol into the stores of the sarcoplasmic reticulum. Its activity is negatively regulated by the closely associated protein phospholamban, and this inhibition is relieved upon phosphorylation of phospholamban by protein kinase A (PKA). [Pg.1119]

The third signalling pathway of TRIF utilises its C-terminus. This region contains a RJQP homology interaction motif (RHIM) that binds RJQP-1 and REP-3. RIP-1 phosphorylates IKK-(3 and the NFkB pathway can be activated. REP-3 is a negative regulator of TREF competing for REP-1 [2]. [Pg.1210]

Clos, J., Westwood, J.T., Becker, P.B., Wilson, S., Lambert, K., Wu, C. (1990). Molecular cloning and expression of a hexameric Drosophila heat shock factor subject to negative regulation. Cell 63, 1085-1097. [Pg.452]

Negative Regulation of FceRI-Dependent Mast Cell Activation... [Pg.54]

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Negative regulation

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