Toxicology information

Health and safety information is available from the manufacturer of every adhesive sold in the United States. The toxicology of a particular adhesive is dependent upon its components, which mn the gamut of polymeric materials from natural products which often exhibit low toxicity to isocyanates which can cause severe allergic reactions. Toxicological information may be found in articles discussing the manufacture of the specific chemical compounds that comprise the adhesives. 

In general, the PCTFE resins have been found to be low in toxicity and irritation potential under normal handling conditions. Specific toxicological information and safe handling procedures are provided by the manufacturer of specified PCTFE products upon request. 

Generalizations on the toxicity of hydrides as a class of compounds are difficult to make because of variations in their chemical reactivity. Furthermore, there is Htde pubHshed toxicological information available. 

HSDB National Library of Medicine s Toxicology Information Program toxicology and the environmental effects of chemicals... 

Comprehensive reviews of medical databases (105) and health and toxicological information systems (106), including search aids in each field, appeared in ARIST pubHcations in 1983 and 1990. Toxicology information was reviewed in 1983 (103) and medical and health information in 1990 (100). Reviews of electronic government information (107) and engineering information systems (108) have also been pubHshed and provide an expansion of database knowledge for readers who require crossover information in these fields. 

Toxicological Information. The toxicity of the higher olefins is considered to be virtually the same as that of the homologous paraffin compounds. Based on this analogy, the suggested maximum allowable concentration in air is 500 ppm. Animal toxicity studies for hexene, octene, decene, and dodecene have shown Httle or no toxic effect except under severe inhalation conditions. The inhalation LD q for 1-hexene is 33,400 ppm for these olefins both LD q (oral) and LD q (dermal) are >10 g/kg. 

Extension Toxicology Network, EXTOXNET, 2nd ed., available in hard copy and electronic form from Resource Center, Cornell University, Ithaca, N.Y., 1994. Contains 139 pesticide information profiles (PIPs), 16 toxicology information briefs (TIBS), and other information on current issues in pesticide toxicology and environmental chemistry. 

Di-2-ethylheccyl Phthalate A Critical Eview of the Available Toxicological Information, CEFIC, Bmssels, Belgium, 1985. 

Exposure to metal carbonyls can present a serious health threat. Nickel carbonyl is considered to be one of the most poisonous inorganic compounds. However, the toxicological information available on metal carbonyls is restricted to the mote common, commercially important compounds such as Ni(CO)4 and Ee(CO). Other metal carbonyls are considered potentially dangerous, especially ia the gaseous state, by analogy to nickel and iron carbonyls. Data concerning toxicological studies on a few common metal carbonyls are Hsted ia Table 6 (185). Additional toxicity data are OSHA personal exposure limits (PEL) for Ee(CO) this is 8 h at 0.1 ppm, whereas for the much more toxic Ni(CO)4 it is 8 h at 0.001 ppm, with a toxic concentration TCLq low (of 7 mg/m ) for human inhalation. 

Process Safety Information Physical, chemical, and toxicological information related to the chemicals, process, and equipment. It is used to document the configuration of a process, its characteristics, its limitations, and as data for process hazard analyses. 

TOXLINE (non-royalty based) Toxicology Information Online National Library of Medicine 8600 Roekville Pike Bethesda, MD 20894 (301) 496-1131 On-line bibliographic database covering the pharmacological, physiological, and toxicological effects of drugs and chemicals. Information is taken from eleven secondary sources. 

Health Hazards Information - Information included are recommended personal protective equipment for hazard materials handling specialist, typical symptoms following exposure to the chemical, general first aid treatment procedures, and various toxicological information including toxicity by ingestion, inhalation and short term exposures. Additional information included are the liquid or solid irritant characteristics and odor threshold data. 

What additional information is required (Toxicology information or reactive chemicals data.)... 

Industrial hygiene/toxicology people need to develop acute and chronic toxicology information on all the materials used and produced in the process. This information should also include the potential products of abnormal reactions. The industrial hygiene member of the team should be prepared to explain the toxicology information on the material safety data sheet (MSDS) to the review team. 

Since the fundamental mcclumisms tliat cause toxic responses are not fully understood, toxicological findings are largely based on observations. Altliough some of the toxicological information relating to hmnans is based on human experience, tlie majority of this information is derived from animal experimentation. 

Agency for Toxic Substances and Disease Registry Division of Toxicology/Toxicology Information Branch 1600 Clifton Road NE, E-29 Atlanta, Georgia 30333... 

Toxicological Profiles are a unique compilation of toxicological information on a given hazardous substance. Each profile reflects a comprehensive and extensive evaluation, summary, and interpretation of available toxicologic and epidemiologic information on a substance. Health care providers treating patients potentially exposed to hazardous substances will find the following information helpful for fast answers to often-asked questions. 

HSDB. 1999. Methyl parathion. Hazardous Substances Data Bank. Bethesda, MD National Library of Medicine, National Toxicology Information Program. April 16, 1999. 

Where sufficient toxicologic information is available, we have derived minimal risk levels (MRLs) for inhalation and oral routes of entry at each duration of exposure (acute, intermediate, and chronic). These MRLs are not meant to support regulatory action but to acquaint health professionals with exposure levels at which adverse health effects are not expected to occur in humans. They should help physicians and public health officials determine the safety of a community living near a chemical emission, given the concentration of a contaminant in air or the estimated daily dose in water. MRLs are based largely on toxicological studies in animals and on reports of human occupational exposure. 

MRL users should be familiar with the toxicologic information on which the number is based. Chapter 2, "Relevance to Public Health," contains basic information known about the substance. Other sections such as Chapter 3 Section 3.9, "Interactions with Other Substances, and Section 3.10, "Populations that are Unusually Susceptible" provide important supplemental information. 

Matthews EJ, Benz RD, Contrera JF. Use of toxicological information in drug design. J Mol Graph Modell 2000 18 605-15. 

Judson PN, Cooke PA, Doerrer NG, Greene N, Hanzlik RP, Hardy C et al. Towards the creation of an international toxicology information centre. Toxicol 2005 213 117-28. 

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