Toxicological Profiles

Monomers containing reactive functional groups ia the ester moiety exhibit the toxicological profile of the functional group and should be considered on an iadividual basis. Consideration of methods of monomer manufacture may be appropriate, as by-products, even at trace levels, may affect the observed biological response. 

W. J. Hayes, Jr., and E. R. Laws, Jr., eds.. Handbook of Pesticide Toxicology, Academic Press, Inc., San Diego, Calif., 1990. Three volume set provides detailed toxicological profiles of more than 250 insecticides, herbicides, and fungicides each compound described by identity, properties, and uses toxicity to humans, laboratory animals, domestic animals, and wildlife includes comprehensive coverage of diagnosis, treatment, prevention of injury, effects on domestic animals, wildlife, and humans - ISjOOO references. 

Agency for Toxic Substances and Disease Registry, Toxicological Profile forBen yene, U.S. Department of Commerce, Adanta, Ga., May 1989. 

Health Effects Assessment for Hexavalent Chromium, EPA/540/1-86-019, United States Environmental Protection Agency (EPA), Sept. 1984 Toxicological Profile for Chromium, Agency for Toxic Substances and Disease Registry (ASTDR), ASTDR/TP-88/10,1989. 

ATSDR s Toxicological Profiles on compact disc. (Lewis Publishers, 1997 CRC Press, Inc.). 

Considerable studies are required to establish the toxicological profile of the drug substance. These must assess its direct toxic effects, together with its potential as a reproductive toxin, mutagen, or carcinogen. 

Toxicological profiles are revised and republished as necessary, but no less than once every three years. For information regarding the update status of previously released profiles, contact ATSDR at ... 

The toxicological profiles are developed in response to the Superfund Amendments and Reauthorization Act (SARA) of 1986 (Public law 99-499) which amended the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA or Superfund). This public law directed ATSDR to prepared toxicological profiles for hazardous substances most commonly found at facilities on the CERCLA National Priorities List and that pose the most significant potential threat to human health, as determined by ATSDR and the EPA. The availability of the revised priority list of 275 hazardous substances was announced in the Federal Register on November 17, 1997 (62 FR 61332). For prior versions of the list of substances, see Federal RegisternoiiCQS dated April 29, 1996 (61 FR 18744) April 17, 1987 (52 FR 12866) October 20, 1988 (53 FR 41280) October 26, 1989 (54 FR 43619) October 17, 1990 (55 FR 42067) October 17, 1991 (56 FR 52166) October 28, 1992 (57 FR 48801) and February 28, 1994 (59 FR 9486). Section 104(i)(3) of CERCLA, as amended, directs the Administrator of ATSDR to prepare a toxicological profile for each substance on the list. 

Toxicological Profiles are a unique compilation of toxicological information on a given hazardous substance. Each profile reflects a comprehensive and extensive evaluation, summary, and interpretation of available toxicologic and epidemiologic information on a substance. Health care providers treating patients potentially exposed to hazardous substances will find the following information helpful for fast answers to often-asked questions. 

Pediatrics Four new sections have been added to each Toxicological Profile to address child health... 

ATSDR. 1989. Decision guide for identifying substance-specific data needs related to toxicological profiles. Atlanta, GA Agency for Toxic Substances and Disease Registry, Division of Toxicology. 

Acute Exposure—Exposure to a chemical for a duration of 14 days or less, as specified in the Toxicological Profiles. 

The Comprehensive Environmental Response, Compensation, and Liability Aet (CERCLA) [42 U.S.C. 9601 et seq ], as amended by the Superflind Amendments and Reauthorization Aet (SARA) [Pub. L. 99-499], requires that the Agency for Toxic Substances and Disease Registry (ATSDR) develop jointly with the US. Enviromnental Protection Agency (EPA), in order of priority, a list of hazardous substances most commonly found at facilities on the CERCLA National Priorities List (NPL) prepare toxicological profiles for each substance included on the priority list of hazardous substances and assure the initiation of a research program to fill identified data needs associated with the substances. 

An update Toxicological Profile for Trichloroethylene was released in April 1993. This edition supersedes any previously released draft or final profile. 

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