Toxicology Information Center

Kathy Iverson, Manager, Toxicology Information Center... 

An effective approach to provide maximal access to these resources is to set up a Toxicology Information Center (TIC), which consists of the earlier noted PC hardware and single, centrally available copies of the noted floppy disk, CD-ROM-based, and laser disk products. By employing a menu-based system (available commercially or by shareware) to access the respective products, one can usually provide entry into each of the products discussed here with a single keystroke. 

Seymour Jablon, Director, Medical Follow-up Agency Robert J. Keehn, Statistician, Medical Follow-up Agency Edna Paulson, Manager, Toxicology Information Center (BOTEHH) Virginia White, Reference Verifier, Toxicology Information Center (BOTEHH)... 

JETOC (1997) Mutagenicity Test Data of Existing Chemical Substances, Tokyo, Japan Chemical Industry Ecology-Toxicology Information Center, pp. 188-190... 

As abuse of these mushrooms increases worldwide, more data is available on the serious side effects. In a 2000 Swiss Toxicological Information Center (STIC) study, researchers examined 161 acute Psilocybe mushroom exposures in which people intentionally ate magic mushrooms. The median age of the person seeking medical attention was 20 years (range 14—56). According to the researchers, Reasons for hospitalization were marked hallucinations, hyperexcitability, panic attacks, coma, and convulsions. As good trips turn bad and euphoria turns to fear and panic, there is no antidote or antitoxin that can make it go away. Thirty-one percent of the people in this study experienced panic attacks severe enough to seek medical attention. 

In a 2000 study which examined 161 acute psilocybin mushrooms exposures reported to the Swiss Toxicological Information Center (STIC), researchers noted that severe complications from psilocybin use were most likely to occur when it was combined with other drugs such as opioids, alcohol, or LSD. Some of the severe complications listed in the study were coma and convulsions. 

MITI (1992). Biodegradation and bioaccumulation data on existing data based on the CSCL Japan. Jap i chemical industry. Ecology-toxicology information center. ISBN 4-89074-101-1... 

Drag overdose Fatal and non-fatal cases of clozapine overdose have been reported [SED-15, 833 SEDA-32, 98]. The minimal dose for severe poisoning and the factors that influence acute human clozapine intoxication have been studied in 73 cases of acute clozapine monointoxication reported to the Swiss Toxicological Information Center [94 ]. The most common symptoms were central nervous system depression (63%), tachycardia (40%), restlessness/agitation (16%), confusion/disorientation (15%), dysarthria (15%), arterial hypertension (11%), bradykinesia (9.6%), respiratory depression... 

Extension Toxicology Network, EXTOXNET, 2nd ed., available in hard copy and electronic form from Resource Center, Cornell University, Ithaca, N.Y., 1994. Contains 139 pesticide information profiles (PIPs), 16 toxicology information briefs (TIBS), and other information on current issues in pesticide toxicology and environmental chemistry. 

The Registry of Toxic Effects of Chemical Substances. The Registry of Toxic Effects of Chemical Substances (RTECS) [70] is a database of toxicological information compiled, maintained, and updated by the National Institute for Occupational Safety and Health (NIOSH). The Occupational Safety and Health Act of 1970 mandated the program. RTECS now contains over 133,000 chemicals as NIOSH strives to fulfill the mandate to list all known toxic substances and the concentrations at which toxicity is known to occur. This database is available for searching through the GOV. Research Center (GRQ service at http // grc.ntis.gov by subscription or by a day pass. 

Japan s Ministry of International Trade has published several books with detailed information on biodegradation tests of several hundred chemicals. This information has now also been made available by the Japan Chemical Industry Ecology-Toxicology and Information Center (JETOC) see Chapter 14 for more details on the MITI biodegradation database. The JETOC also published a compendium of mutagenicity test data of several hundred chemicals. The books can be purchased from JETOC and partial data can be found at various websites, such as members.jcom.home.ne.jp/mo-ishidate/. 

The Environmental Teratology Information Center Backfde (ETICBACK) is a bibliographic resource primarily on developmental toxicology studies published from 1950 to 1989 (before the DART system was established). Each ETICBACK record provides bibliographic information, CAS registry numbers, and special keywords related to species and treatment details. ETICBACK is available online through NLM s TOXNET system . 

Chemicals Inspection and Testing Institute Japan (1992) Data of existing chemicals based on the CSCL Japan. Japan Chemicals Industry Ecology-Toxicology 8c Information Center... 

Developmental and Reproductive Toxicology Da-tabase/Environmental Teratology Information Center Backfile (DART/ETICBACK) ... 

Foster a better understanding of the principles and practice of clinical toxicology in order to prevent poisoning and to promote better care for the poisoned patient, particularly through poison information centers and poison treatment centers. 

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