TSCA Toxic Substance Control Act

Toxic Substances Control Act (TSCA) of 1976 (15 U.S.C. 2601 et seq.) provides the U.S. EPA with the authority to regulate industrial chemicals and mixtures (TSCA 1976). Section 2(b)(1) of TSCA states that it is the policy of the United States that adequate data should be developed with respect to the effect of chemical substances and mixtures on health and the environment and that the development of such data should be the responsibility of those who manufacture [which is defined by statute to include import] and those who process such chemical substances and mixtures [.] The core sections of TSCA that provide authority for implementing the above policy are discussed below. 

Chemical substances not included on the TSCA inventory are considered new chemical substances, with some exemptions, and require compliance with premanufacturing notification requirements set forth under Section 5(a)(1)(A) of 

Continued reporting requirements are placed on persons that manufacture, process, or distribute in commerce any chemical substance or mixture and include (1) maintaining records of significant adverse reactions to health or the environment, alleged to have been caused by the substance or mixture (Section 8(c) of TSCA) and (2) immediately informing the U.S. ERA of ... information which reasonably snpports the conclnsion that such chemical substance or mixture presents a substantial risk of injnry to health or the environment, nnless the person has actual knowledge that the U.S. ERA has been adeqnately informed (Section 8(e) of TSCA). 

Section 4(a)(1) of TSCA mandates that the U.S. ERA require by rule that manufacturers and/or processors of new or existing chemicals substances and mixtures conduct testing if the Administrator of the U.S. ERA finds that [t]he manu-factnre, distribntion in commerce, processing, nse, or disposal of a chemical substance or mixtnre, or any combination of snch activities, may present an unreasonable risk of injury to health or the environment [emphasis added]. A TSCA Section 4 test rule may require manufacturers and processors to condnct testing on enviromnental fate, ecotoxicity, acute toxicity, genetic toxicity, repeated dose toxicity, or developmental and reprodnctive toxicity. 

HaSDR rules require producers and importers to submit to the U.S. EPA copies and lists of certain types of unpublished health and safety studies for the listed chemicals. Submitters under the HaSDR rule are also requested to provide robust summaries of health and environmental effects studies. In addition, when the ITC designates chemicals for testing, the U.S. EPA is required to initiate proceeding under a TSCA Section 4(a) test rule, if the PAIR and HaSDR data trigger a finding of unreasonable risk of injury to health or the environment. 

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Table 5. Grignard Reagents Listed on the U.S. EPA Toxic Substances Control Act (TSCA) List...

Information on health and safety considerations cited herein for Ryton PPS powders and pellets can be found in Reference 157. Ryton PPS [26125-40-6] is listed in the Toxic Substance Control Act (TSCA) Inventory of Chemicals. 

The two main federal agencies involved in the protection of human health and the environment are the Environmental Protection Agency (EPA) and the Occupational Safety and Health Administration (OSHA). EPA s principal concern is the protection of the environment, in most cases, the area outside of an industrial faciUty. There are 10 regional offices that carry out the regulatory functions of the agency (Table 1). Primary laws covered by EPA are the Clean Air Act Amendments (CAAA), the Clean Water Act (CWA), Resource Conservation and Recovery Act (RCRA), Comprehensive Environmental Response, Compensation, and LiabiUty Act (CERCLA), Toxic Substances Control Act (TSCA), and Eederal Insecticide, Eungicide, and Rodenticide Act (FIFRA). 

Toxic Substances Control Act. EPA regulates the manufacture, use, and exposure to ha2ardous or toxic chemicals under a number of laws. Eor the chemical industry, the law of prime concern is the Toxic Substance Control Act (TSCA) (10), which was passed by the U.S. Congress in 1976. The two main goals of TSCA are acquisition of sufficient information to identify and evaluate potential ha2ards from chemical substances, and regulation of the production, use, distribution, and disposal of these substances. 

Styrene is Hsted in the U.S. Toxic Substance Control Act (TSCA) Inventory of Chemicals. It is not confirmed as a carcinogen but is considered a suspect carcinogen. The recommended exposure limits are OSHA PEL 50 ppm, ACGIH TLV 50 ppm. For higher concentrations,... 

Toxic Substances Control Act (TSCA) Hazardous Materials Transportation Act (HMTA) Safe Drinking Water Act (SDWA)... 

Vinyl chloride is Hsted as "ethene, chloro-" on the Toxic Substances Control Act (TSCA) inventory and on the Canadian Domestic Substances List (DSL). It is Hsted as "chloroethylene" on the European Inventory of Existing Commercial Chemical Substances (EINECS), bearing the identification number 2008 310 (149). 

All four butanols are registered ia the United States on the Environmental Protection Agency Toxic Substances Control Act (TSCA) Inventory, a prerequisite for the manufacture or importation for commercial sale of any chemical substance or mixture ia quantities greater than a 1000 pounds (454 kg). Additionally, the manufacture and distribution of the butanols ia the United States are regulated under the Superfund Amendments and Reauthorization Act (SARA), Section 313, which requires that anyone handling at least 10,000 pounds (4545 kg) a year of a chemical substance report to both the EPA and the state any release of that substance to the environment. 

The United States has the most laws regarding environmental safety and health. The National Environmental PoHcy Act (NEPA) of 1969 has resulted in the following acts Eederal Insecticides, Eungicide and Rodenticide (EIERA), Resource Conservation and Recovery (RCRA), Superfund (CERCLA), Superfund Amendments and Reauthori2ation Act (SARA) Plus Tide III, Toxic Substance Control Act (TSCA), Clean Water (CWA), Water Quahty, Safe Drinking Water (SDWA), and Waste Minimi2ation and Control. 

The two most important pieces of chemical control legislation enacted affecting the dye and pigment industries are the United States Toxic Substance Control Act (TSCA) and EEC s Classification, Packaging, and Labeling of Dangerous Substances and its amendments. Table 2 is a comparison of TSCA and the 6th Amendment of the EEC classifications. 

The Toxic Substances Control Act (TSCA) was enacted in 1976 to identify and control toxic chemical ha2ards to human health and the environment. One of the main provisions of TSCA was to estabUsh and maintain an inventory of all chemicals in commerce in the United States for the purpose of regulating any of the chemicals that might pose an unreasonable risk to human health or the environment. An initial inventory of chemicals was estabhshed by requiring companies to report to the United States Environmental Protection Agency (USEPA) all substances that were imported, manufactured, processed, distributed, or disposed of in the United States. Over 50,000 chemical substances were reported. PoUowing this initial inventory, introduction of all new chemical substances requires a Premanufacturing Notification (PMN) process. To be included in the PMN are the identity of the new chemical, the estimated first year and maximum production volume, manufacture and process information, a description of proposed use, potential release to the environment, possible human exposure to the new substance, and any health or environmental test data available at the time of submission. In the 10 years that TSCA has been in effect, the USEPA has received over 10,000 PMNs and up to 10% of the submissions each year are for dyes (382)... 

Toxic Substances Control Act, 1976 The two major goals of the Toxic Substances Control Act (TSCA), passed by Congress in... 

Another section of the EPA, the Office of Prevention, Pesticides, and Toxic Substances (OPPT), has recently updated and harmonized its testing guidelines for evaluating the developmental and reproductive effects of pesticides and industrial chemicals to include an assessment of endocrine disrupting properties. These guidelines will be used in future testing of pesticides under both the Toxic Substances Control Act (TSCA) and the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA). 

Operating under contract to EPA, the TCSA Hotline provides technical assistance and information about programs under the Toxic Substances Control Act (TSCA), including the Asbestos School Hazard Abatement Act (ASHAA), the Asbestos Hazard Emergency Response Act (AHERA), and the Lead Exposure Reduction Act. Hours 8 30 a.m. - 5 00 p.m. EST weekdays. 

Fourteen formulations of chemical alternatives were submitted to EPA under confidentiality and they were assessed based on numerous human health and ecotoxicity endpoints in addition to bioaccumulation potential and environmental persistence. They were also screened for potential exposure to workers, users and the aquatic environment. Where data gaps existed, EPA experts used models and chemical analogs to estimate the hazard for a particular endpoint. The literature and test data reviews were published in the final report, Environmentally Preferable Options for Furniture Fire Safety Low Density Furniture Foam . In addition, each hazard endpoint was ranked with a concern level (High, Moderate or Low) based on the criteria used by the EPA s New Chemicals Program to rate the concern level of new chemicals submitted under the Toxic Substance Control Act (TSCA). As seen in Figure 8.2, where the hazard endpoint rankings are bold, the value is based on experimental data. Where the hazard endpoints are presented in italic font, the value is estimated based on models or chemical analogs. In this way, detailed hazard information was summarized and presented in a clear and concise format. 

TSCATS is an online index to unpublished, nonconfidential studies covering chemical testing results and adverse effects of chemicals on health and ecological systems. The studies are submitted by US industry to EPA under several sections of the Toxic Substance Control Act (TSCA). There are four types of documents in the database Section 4 chemical testing results, Section 8(d) health and safety studies, Section 8(e) substantial risk of injury to health or the environment notices, and voluntary documents submitted to EPA known as a For Your Information (FYI) notice. 

Federal Register, Toxic Substances Control Act (TSCA), 15 U.S. Code s/s 2601 et seq. 1976, U.S. Government, Public Laws, 2009. Available at http //www.access.gpo.gov/uscode/titlel5/chapter53. html... 

Most of the provisions of the Toxic Substances Control Act (TSCA) of 1976 (PL 94-469) rely in some way on risk assessment of chemicals. Under the reporting requirements of the statute, any manufacturer, processor, or distributor of a chemical for commercial purposes must inform the EPA immediately after discovering any information which "reasonably supports the conclusion" that a chemical substance or mixture "presents a substantial risk of injury to health or to the environment" unless the EPA Administrator has been adequately informed already. EPA is mandated to establish regulations for testing new or existing substances when it is determined that there is not enough health or environmental information, that testing is necessary to develop such information and that the chemical or mixture "may present an unreasonable risk of injury to health or the environment."... 

Yes Toxic Substance Control Act (TSCA)—. PL 102-550 U.S. Congress 1992a... 

Toxic Substances Control Act (TSCA) List, Grignard reagents listed on, 72 833—834t, 75 256, 259 Toxic substances, regulation of, 27 829 removal of, 74 423 in microbial transformations, 76 412 Toxic use reduction (TUR) regulations, 27 590... 

The set of 469 chemicals used in this study was obtained from the Assessment Tools for the Evaluation of Risk (ASTER) database [50] and it represents a subset of the Toxic Substances Control Act (TSCA) Inventory [51] for which VP was... 

The Toxic Substances Control Act (TSCA) refers to "new chemicals" as those not on the TSCA Inventory of Chemical Substances which lists about 55,000 existing commercial chemicals. All new chemicals must enter EPA s premanufacture notification program (PMN) for review before manufacture. This program is the most complete record of development of new chemicals by U.S. industry over the past 2 1/2 years. To date over 1,000 notices have been submitted, many including confidential business information (CBI). Despite the CBI, it is possible to summarize EPA s experience with new chemical substances and to evaluate the PMN program and its impact on product innovation. That is essentially the aim of this paper. 

The goal of the Toxic Substances Control Act (TSCA) is to provide authority to regulate chemical substances which present an unreasonable risk of injury to health or the environment. An important feature of TSCA requires the administrator of the Environmental Protection Agency (EPA) to examine such data on existing chemicals and, when it is insufficient, to direct industry to conduct tests. 

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