Toxic Substances Control Act TSCA 15 U.S. Code 2601 et seq

Under Section 4(a) of TSCA, the U.S. EPA can require testing of a chemical substance or mixture to develop data relevant for assessing the risks to health and the environment. Section 8(d) of TSCA requires that hsts of health and safety studies conducted or initiated with respect to a substance or mixture be submitted to the U.S. EPA. All new toxicological data of the effects of a chemical not previously mentioned must be reported immediately if the data reasonably supports the conclusion that such substance or mixture presents a substantial risk of injxuy to health or the environment [Section 8(e) of TSCA]. Testing (Section 4 test rule) was required for several of the solvents earher (e.g., commercial hexane for which new toxicological information was reported to the U.S. EPA since 1992), and any new toxicological information will have to be reported to the U.S. EPA xmder Section 8(e) and 8(d). 

If a chemical s manufacture, processing, distribution, use, or disposal would create unreasonable risks, the U.S. ERA, under the TSCA, can regulate it, ban it, or require additional testing. TSCA mandates the U.S. ERA to monitor and control the use of toxic substances by requiring the Agency to review the health and environmental effects of new chemicals [referred to as Premanufacturing Notice or PMN Section 5(a)(1) of TSCA] and chemicals already in commerce. The U.S. ERA also has Significant New Use Rules (SNUR) under Section 5(a)(2) ofTSCA which provides away for the U.S. ERA to restrict uses of a chemical substance already in commerce that are proposed for new uses. All of the solvents discussed are already commercially available, so a PMN would not apply some could be 

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Toxic Substances Control Act (TSCA) (15 U.S. Code 2601 et seq.) Provides a system for identifying and evaluating the environmental and health effects of new chemicals and chemicals already in commerce. 

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