Testing guidelines

ChemicalFate Testing Guidelines, NTIS No. PB82-233008, U.S. Environmental Protection Agency, Washington, D.C., 1982. 

Another section of the EPA, the Office of Prevention, Pesticides, and Toxic Substances (OPPT), has recently updated and harmonized its testing guidelines for evaluating the developmental and reproductive effects of pesticides and industrial chemicals to include an assessment of endocrine disrupting properties. These guidelines will be used in future testing of pesticides under both the Toxic Substances Control Act (TSCA) and the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA). 

Identification of gaps in existing OECD Test Guidelines for these endpoints. 

Note that filter aid selection must be based on planned laboratory tests. Guidelines for selection may only be applied in the broadest sense, since there is almost an infinite number of combinations of filter media, filter aids, and suspensions that will produce varying degrees of separation. The hydrodynamics of any filtration process are highly complex filtration is essentially a multiphase system in which interaction takes place between solids from the suspension, filter aid, and filter medium, and a liquid phase. Experiments are mandatory in most operations not only in proper filter aid selection but in defining the method of application. Some general guidelines can be applied to such studies the filter aid must have the minimum hydraulic resistance and provide the desired rate of separation an insufficient amount of filter aid leads to a reduction in filtrate quality — excess amounts result in losses is filtration rate and it is necessary to account for the method of application and characteristics of filter aids. 

Gourmelon, A. and Ahtiainen, 1. (2007). Developing Test Guidelines on invertebrate development and reproduction for the assessment of chemicals, including potential endocrine active substances—The OECD perspective. Ecotoxicology 16, 161-167. 

CMA), and the USDA are excellent sources of information relative to current regulatory activities which will impact both production agriculture and the setting of tolerances to ensure food safety. The purpose of this article is to summarize the key impacts of the 1996 OPPTS 860 Residue Chemistry Test Guideline series as they impact research associated with field production of RAC samples to be used in establishing safe tolerance limits for pesticides used in commercial agricultural production. 

The guidelines for field residue trials currently in effect are included in the Residue Chemistry Test Guidelines . The guidelines consist of 17 chapters or sections each... 

Supplementary Guidance on Use of OPPTS Residue Chemistry Test Guideline 860.1500 (residue zone maps - Canadian extension) 4/8/98] and efforts are under way to extend the map into Mexico. The EPA cropping regions in which to locate field residue trials in a study are listed in Table 5. Other important items discussed in OPPTS 860.1500 include ... 

Both the Study Director and a QA agent should be present at the first application. SOPs must be followed, documentation must be correct and complete, equipment must be calibrated and its maintenance records must be documented, safety procedures must be in place, and the fine points of application methodology should be discussed with the applicator. Guidelines for applications can be found in Residue Chemistry Test Guidelines , Office of Prevention, Protection and Toxic Substances (OPPTS) 860.1500. 

EPA Residue Chemistry Test Guidelines OPPTS 860.1000, Background, United States Environmental Protection Agency, Washington, DC (1996). 

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